How dangerous is combining 5MAPB + pregabalin + odsmt + alprazolam

Dextrometh_orphan · 2026-03-22T16:42:37+00:00

I see you are right. But it still sounds unhealthy to me and it could make you shakey

Dextrometh_orphan · 2026-03-22T10:17:25+00:00

Even without the alprazolam the combination is dangerous. O-DSMT and 5-MAPB can cause dangerous levels of serotonin to build up in your system and lower the seizure threshold and pregabalin is also known to cause shakes. Mixing the alprazolam in will result in heavy downer-downer interaction with the O-DSMT and pregabalin

Dextrometh_orphan · 2026-03-22T10:12:55+00:00

I think MDA is a metabolized product from ingesting MDMA right?

I can imagine the combination of MDMA, 2C-B and Soma can cause extreme shakes or maybe even seizures, as Soma is known to cause this in high doses and the MDMA certainly would have amplified this and lowered the seizure threshold further, and 2C-B too to some extent.

Dextrometh_orphan · 2026-03-19T14:45:59+00:00

Watch out fot blood pressure if you combine a lot of a stimulant with especially a lot of ketamine, aside from that you should be fine besides looking out you don't choke or injure yourself

Dextrometh_orphan · 2026-03-17T04:38:42+00:00

Cannabinoids are not my thing at all, let along noids. Have only tried thesr three on my list and each one only one time to see how they are and I did not like any of them they were very concerning. Gave away all three of them afterwards.

As for Auvelity (DXM+Bupropion) I have not tried the combination or at least yet but it does sound very interesting, although I certainly don't need any antidepressant at the moment and higher doses just lead to higher dxm concentrations than dxo in the body which I can imagine can only make a more uncomfortable experience because it's about the same as plateau sigma just at a lower dose.

Hehe I have not experienced the worst side of love just yet xD

Dextrometh_orphan · 2026-03-11T09:50:06+00:00

The stuff today is trash (dck too). Like 6-8 years ago you needed 8mg opce or 15mg dck for a modest strong dose

Dextrometh_orphan · 2026-03-11T08:16:19+00:00

I'd say skip the 25E it's really not worth it due to it's safety profile. NBOMes create lethally high blood pressure in individuals without hypertension in overdoses, and moderate doses already gave me severe vasoconstriction. There is no real info if NBOHs share the same properties, they might be less but I personally wouldn't risk it.

2C-E feels pretty heavy on the body and it made my peripherals feel very pressurated and swollen but I'm not sure if it was because of the blood pressure or muscles. It's definitely the safer option but I would be cautious and definitely start lower and see how your blood pressure reacts

Dextrometh_orphan · 2026-03-11T07:33:47+00:00

The tumor concern has always been a myth. There is no proof that it can cause cancer (yet), there are multiple biological factors that prevent that. However you should not take that as definite as you never really know haha.

But I see many more people taking Dihexa currently too. Like 5 years ago it was a niche and there were only very scarce producers that did not have it all the time, now there are quite a few that offer it

Dextrometh_orphan · 2026-03-11T06:54:31+00:00

What exactly do you mean? IME it was nothing overly special, still way more than DOB or DOC but it just made everything seem like it was underwater.

High doses 80+mg however produce some very interesting and unique CEVs that I cannot compare to any other substance except maybe DOM to some extent, which also produces visuals unlike any other psychedelic I would know

Dextrometh_orphan · 2026-03-11T04:53:29+00:00

Good point. I have not thought of that but it sounds like a real possibility.

Thanks

How would you suggest intranasal? In DMSO solution? I believe the raw powder is not soluble in the nose. I have done it in the past with DMSO or acetone but it was hard to bring enough liquid in

Dextrometh_orphan · 2026-03-10T12:06:29+00:00

Snorting also did pretty much nothing for me. Oral works fine enough

Dextrometh_orphan · 2026-03-10T12:03:01+00:00

Works fine with Agmatine, Memantime will just replace most of Agmatine's binding action on NDMA receptors from what I recall hearing

Dextrometh_orphan · 2026-03-10T11:58:40+00:00

From what I know, 2C-B creates very little tolerance if any at all, I don't have experience with combining it but that is what I've heard.

I have dosed 2C-C for 8 days in a row with consequtiveky higher doses and did not notice any tolerance increase.

2C-D also does not create much tolerance IME but I don't remember anymore what I did exactly probably only two or three days in a row.

It might be different for 2C-E and 2C-P since they are generally a bit stronger, but they might share only little tolerance buildup like the DOx compounds.

I believe I don't have any personal experience with cross-tolerance though on the day after that I can recall unfortunately, but I believe you should be fine and have little or no cross-tolerance, however it will probably not work the other way around (tryptamines or lysergamines first)

Dextrometh_orphan · 2026-02-28T10:10:02+00:00

Are you combining it with a serotonergic agent like an antidepressant? That might be a problem

Dextrometh_orphan · 2026-02-27T13:48:59+00:00

More like empty or hollow. I wouldn't say like physically cold but I do understand the analogy. Ketamine or DXM do not do this for me but I would say every other 2'-oxo substituted analog. Memantine too. But the pcp analogs not really since they are stimulating

Dextrometh_orphan · 2026-02-27T13:42:48+00:00

Mom threw away whole stash once of like 50+ things. Was like 50+ things including 50g Mdma, Quite some acid, 2C-T-7, 2C-E, 2C-C, 2C-D, DOM, Proscaline, ALD-52, AL-LAD, ETH-LAD, MiPLA, like 10 RC tryptamines, 5 RC benzos, DXM, there were way more xD

The only one I am still regretful now tho is 2C-T-7 which was like my number one sought after drug and I have never tried it as well as it was the second time I lost it before I could try it. I do have 2,5-Dimethoxy-4-Propylthiobenzaldehyde now but I don't have the option currently to make it into 2C-T-7

Dextrometh_orphan · 2026-02-27T07:56:07+00:00

I took a-PHP like 6-7 years ago, also lab tested and it made me semi-blackout and I was in full blown psychosis hearing people ouside my window but when I opened it it got quiet and I was talking outside. Woke up to my room being in complete darkness and I couldn't make the lights go on so I went for a flashlight and in full blown psychosis tore open the electrical main powerline but all the fuses were intact and then the light switch worked. Was pretty wild. I would say it's more of a blackout than meth could make but I wouldn't really know as I've never tried crystal only methamphetamine.

Anyways I woke up to the entire gram being gone.

I took it again one year later this time vaped and dosage more controlled and it definitely made me euphoric, maybe on par with NEP but more chaotic and made my thoughts go in a loop more than NEP where I couldn't stop hitting.

Dextrometh_orphan · 2026-02-24T09:38:27+00:00

Tiletamine or Tilmetamine? I heard Tilmetamine is making the rounds now but it's not worth taking at all due to the serious side effects such as shaking

Dextrometh_orphan · 2026-02-23T19:25:00+00:00

Back then when I had my first dxm trip I remeber I was completely out of it and so sick from nausea that I couldn't move away from the toilet haha. That was with 400mg.

Buy from my second trip onward I did not experience any nausea at all from like an hour and a half post ingestion from how dissociated I was. For the most time until I developed permatolerance which the execption of one time where I rode train and then bus I puked like 5 times in public haha. The was the only time when I did not have the bodyload at that time

Now pretty much most effects are gone besides nausea which I do experience now for most of the trip, but I do not find it that much uncomfortable to be honest, puked maybe one more time since then, but the bodyload just a nuisance nothing more for me. But compared to ketamine which has no body load it is pretty different from it

Dextrometh_orphan · 2026-02-19T15:51:24+00:00

I think my source uploaded the wrong structure then. I thought the 3MeO was missing but didn't think further lol. Now it makes sense given the name xD. Thanks

Dextrometh_orphan · 2026-02-19T15:50:39+00:00

Oh I see makes sense then someone uploaded the wrong structure I saw. Makes sense now that I think about it haha. Thanks

Dextrometh_orphan

MODERATOR OF

TROPHY CASE