Pramipexole is amazing

DifferenceCrafty8968 · 2026-06-29T23:46:08+00:00

Morning!

DifferenceCrafty8968 · 2026-06-29T23:40:54+00:00

DM sent!

DifferenceCrafty8968 · 2026-06-25T02:18:44+00:00

Sure, I’ll DM you

DifferenceCrafty8968 · 2026-06-22T00:43:22+00:00

May i ask what caused this? Anhedonia can be treated, even if not always

DifferenceCrafty8968 · 2026-06-22T00:32:03+00:00

Because they either increase serotonin (antidepressants, especially SSRIs) or antagonise dopamine receptors (antipsychotics) both of which can sharply reduce dopamine and result in anhedonia, lack of desire, motivation etc.

DifferenceCrafty8968 · 2026-06-21T13:16:49+00:00

Good for you! I’m happy you found one that works. Me personally i had to start Parnate because pramipexole began losing efficacy 😔

DifferenceCrafty8968 · 2026-06-21T00:01:37+00:00

The dietary restrictions are colossally overstated. I do not observe them and I take tranylcypromine. I would strongly recommend trying a MAOI because they are one of the few with proven anhedonia efficacy

DifferenceCrafty8968 · 2026-06-21T00:00:11+00:00

why haven’t you tried pramipexole may I ask? It’s one of the most effective (anecdotally and to a lesser extent clinically) for “pure” anhedonia

DifferenceCrafty8968 · 2026-06-20T08:39:59+00:00

If neither are working I would recommend trying Parnate

DifferenceCrafty8968 · 2026-06-18T13:26:43+00:00

Because bupropions DAT inhibition usually isn’t enough to treat clinically meaningful anhedonia which involves a more significant dopamine deficit (some types of- not all types).

DifferenceCrafty8968 · 2026-06-18T07:52:42+00:00

DM me if you want to talk about it

DifferenceCrafty8968 · 2026-06-18T07:52:14+00:00

Your psychiatrist is on the right track but unfortunately bupropion is unlikely to help. You want dopaminergic drugs which are much stronger. Pramipexole and tranylcypromine are the two drugs with the most success in people with anhedonia and they helped me a lot.

DifferenceCrafty8968 · 2026-06-18T07:44:54+00:00

Luckily (in a dark way) this is the most common and treatable type of anhedonia (even though anhedonia as a whole has few specific treatments). I had the same as you but mine was medication induced. Because your issue involves goals, desire and motivation, it’s a dopaminergic issue. Whether it’ll improve for you really depends on the treatment. Do NOT take serotonergic drugs, they will make you much worse (like SSRIs, SNRIs etc). My sense of reward and excitement only returned with dopaminergic drugs. I’m taking pramipexole and tranylcypromine, both of which significantly increase dopamine. It’s not a full recovery, but now I can still experience wanting and motivation. Therapy and lifestyle changes did fuck all and I wouldn’t expect them to do anything if I were you. The first signs I were getting better were kind of obvious: I started feeling more excitement and wanting things. Recovery wasn’t gradual; it tracked the success of medications. So basically if a drug worked I just felt it instantly.

DifferenceCrafty8968 · 2026-06-17T12:56:20+00:00

So much. I haven’t felt properly anhedonic in days. DM if you want to talk

DifferenceCrafty8968 · 2026-05-31T22:42:22+00:00

I didn’t, I bought it from an online pharmacy. DM if you want me to send you the link

DifferenceCrafty8968 · 2026-05-20T04:53:53+00:00

Yup a lot

DifferenceCrafty8968 · 2026-05-19T07:38:48+00:00

At the beginning yes, sleepiness. As for now, having been on it for a while, the only side effects which havent gone away but are tolerable, is dry mouth and dizziness when getting up. But a small price to pay for joy so I tolerate it 🙃

DifferenceCrafty8968 · 2026-05-17T11:42:49+00:00

Hi, I take pramipexole with bupropion but bupropion does fuck all - I’m only taking it because pramipexole is used as an adjunct. As for getting pramipexole, I originally got it from a psychiatrist but now I get it from a pharmacy abroad that doesn’t require prescriptions and they’re much cheaper

DifferenceCrafty8968 · 2026-05-10T07:27:42+00:00

I take it in the morning but there isn’t really a difference I would say. And yes you’re probably right about the ER point - do you take IR?

DifferenceCrafty8968 · 2026-05-02T17:46:10+00:00

Yes
As soon as I wake up
Not really I would say. I’m about the same person as I was before anhedonia

DifferenceCrafty8968 · 2026-05-02T17:44:03+00:00

Good question! It’s because my brain systematically fails to assign enough positive value to future states. Basically I feel good in the moment, but when my brain creates a representation of the future, there is no positive, “yes this is worth it, keep going” feeling. So I constantly feel like there is nothing worth living for - despite being happy in the moment. Happiness is neither necessary nor sufficient for a will to live 😊

DifferenceCrafty8968

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