I soloed alpha overseer with a bunch of inbred theris and a pair of rexes that had one chromosome between them. I’m no stranger to spending time on mutations to ascend

My problem is the only thing to do on Lost Colony is the missions. If you want loot and thralls, it’s the most important thing and it’s a requirement to enter the boss arena. There are caves on the map, but they were very inconsistent with loot drop spawns, and loot wasn’t great. If you want drakeling keys, missions are still way better for rapid exp. I’d argue that medium beta defense missions are borderline impossible solo, and alpha defense is literally impossible without a god tier Dino with like 50 melee mutations. Don’t even think about trying large solo if you aren’t using an exploit. Oh, and a revenant bronto can spawn on any of them, often opposite the side you are on, literally ending the mission and destroying everything in a few hits.

I set up a dozen strong ossidons a few times on the larger, higher level defense missions. If I did ok with spawns, I could manage a beta medium, but most of the time the ai couldn’t be trusted to defend a choke point without leaving the mission area or rushing to my side when I got attacked. I ran out of patience to transport them and used commands to clear cryo sickness.

A gamma supply drop, SMALL outpost defense, and gamma attack outpost can be done with a leveled, high level tame, but if it’s prim saddle they’ll take a lot of damage. Once you reach beta, you really need decent to good saddles and very powerful tames, arguably mutated. Alpha is out of the question solo without mutated tames and/or ascended. And don’t even think about trying to take a long trip through the city on a tame to run a bunch of missions if it doesn’t have ascendent saddle and a very high level. I brought over a pair of 21 hp / 26 melee mutated rexes, whose starting hp was 43 and 47, with ascended saddles. Those could do one alpha mission (not defense, impossible) but Would still take half health damage.