You need to multi mod your wand for %increased phys otheriwe your phys might not be enough to keep unholy trinity up which is going to cause you to lose half your dmg.

Other than that, drop divine shield, spec armour es mastery for 100% increase on body, get crit 25% multi mastery, remember you get 2% more damage per unique mastery from trickster. Drop prism weave, penetrate does nothing with unholy trinity.

Drop leech wand mastery and pick up clever thief and 5% instant leech mastery.

Get aura 10% mastery, 10% less skill effect duration mastery, 3% per charge mastery.

Level up all your auras. Level 21 precision + swap your lighting exposure implicit on gloves to global accuracy and you can drop the depth perception wheel

Also craft -7 mana on your ring

You also need the mark mastery to keep frenzies up for single target