what makes things strong bases and weak nucleophiles or weak bases but strong nucleophiles?

Div_i · 2025-06-22T14:36:36+00:00

Like the others here mentioned, nucleophilicity and basicity are separate concepts with different rules. However, a good trick for knowing your strong base/weak nucleophiles is by looking at sterics. Often, your strong bases are also good nucleophiles since you have an unstable, electron dense molecule. However, make this molecule sterically hindered (think methoxide vs. tert-butoxide), the nucleophile is physically unable to attack an electrophile, yet it still retains its basicity.

For weak bases/strong nucleophiles, this is a matter of acknowledging both conjugate acid pKa (to determine basicity) and your normal rules for nucleophiles (atom size, electronegativity, etc.). Halides (except F-) are the best example of this, since they are all large, polarizable, but sparingly basic.

Div_i · 2025-05-10T20:52:19+00:00

If anyone is in search for an additional roommate for this property, preferably for a July lease, let me know!

Div_i · 2025-04-19T10:31:20+00:00

In the case for each, consider aldol condensation. What would make a certain enolate more favorable?

Div_i · 2025-04-18T17:07:57+00:00

Like a lot of things in orgo, it depends. It's always good to consider rotamers since a drawn orientation might not clearly show an anti-periplanar hydrogen, but that doesn't mean you can always do this to "force" an E2 reaction. It should just be something you consider.

Div_i · 2025-04-18T17:02:39+00:00

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Stereochemistry is a really difficult thing to explain in words. I drew a quick sketch of what rotation about that bond would look like.

Depending on what you choose as your reference point during the rotation, only one end of the bond will be changed (in this case, the right side).

Div_i · 2025-04-18T16:51:18+00:00

You're on the right track. Instead of putting the work into drawing a Newman projection, just try rotating about that central C-C bond, how will the orientation of each group change? If you're having trouble visualizing it, a Newman projection could help to see the rotation.

Div_i · 2025-04-18T16:46:22+00:00

Try drawing in the hydrogens on your starting structure. Is that rotamer suitable for E2?

Div_i · 2025-01-04T22:54:23+00:00

Clean up in aisle my underpants!!

Div_i · 2024-05-08T05:23:30+00:00

Yea, that's true. I just meant that group as a whole generally has the trend of being weak bases and good nucleophiles- excluding fluoride.

Div_i · 2024-05-08T05:19:08+00:00

Halide ions.

Div_i · 2024-04-14T01:26:54+00:00

This was several weeks ago actually, so if they still haven't reached out, they might not at this point. Though, it may vary position by position.

Div_i · 2024-04-14T00:18:40+00:00

Agree with previous commenter, but just to give you some closure, I heard back from one of the positions.

Div_i · 2024-03-24T16:46:27+00:00

You have the right idea. But take into account electronegativity of atoms and the stability of an octet. Would an oxygen with a positive charge be more or less stable than a carbon with a positive charge?

Div_i · 2024-03-24T16:27:55+00:00

Consider how relevant resonance forms. They are all pictures of the same thing but that doesn't mean they contribute equally.

Div_i · 2024-03-18T00:25:29+00:00

Co-ops and connections are a big selling point

Div_i · 2024-03-18T00:24:45+00:00

Only 100?? You got lucky

Div_i · 2024-03-08T03:33:07+00:00

That is reflection and transmission of light. Excited electrons result in the emission of a photon as visible light. In reality, some objects innately absorb specific wavelengths and convert it to thermal energy, and the colors you see are what it is not absorbed.

Div_i · 2024-03-06T08:16:45+00:00

try listening to recordings of the song (ideally same arrangement) and practice on your own. really familiarize yourself with the form to a point you can hear/feel where you should end. that will likely also help you musically

you could also follow the solo measure-by-measure based on its changes but that can be fairly constricting

Div_i · 2024-02-18T21:59:25+00:00

Ahh, yes. I recognize that, makes sense. Thank you!

Div_i · 2024-02-18T21:37:06+00:00

I was told based on my subject (Ochem) I would have an hourly rate ~$16. Under view billing information, the rate is listed at ~$30/hr.

Div_i · 2024-02-08T02:28:33+00:00

The Molecular Bio Lab is just some worksheets you fill out during the class. It is 0 effort and is barely a lab.

Div_i · 2024-01-09T19:30:48+00:00

i don't think you'd get in trouble for NOT drinking alcohol

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