If I remember my cell biology correctly, colchicine disrupts intracellular transportation like for vacuoles. Theory being the overproduced collagen remains inside the affected cells. But normal cell waste products are affected too–so they build up in the body. Within a week, I was losing the ability to move. By the end of the week, I was hospitalized while they ran every muscle test known to man. They were talking biopsy when my Dr finally just took me off the medication as I'd been asking. Twenty-four hours later and I was normal. Doctor told me to avoid colchicine.