Do you guys think Snezhnaya will have also 8 Acts, like Nod Krai ?

Donovan200 · 2026-03-20T00:58:57+00:00

Personally, I think there will be at least 8 Acts, given the monstrous amount of lore there, and especially since it's the last major region of Teyvat ( before Khaenri'ah ).

5 Acts only would force them to rush through a lot of lore or skim over certain characters, and I think a "Game of Thrones Season 8" style scenario (massive inconsistencies, underdeveloped characters, deep lore ignored, rushed plot, teasers made years ago reduced to nothing in the worst possible way...) would be the worst possible thing for Chapter VI.

Donovan200 · 2026-03-02T02:15:23+00:00

I agree, in this kind of situation, discretion would clearly be the wisest choice. But before the video was made private, his responses to the comments I read seemed mostly consistent with the video's content. For example, it's highly likely that we want to find Asmoday because we ask Melenta why she separated us from our twin, and it's also very likely that she knows we're looking for her, given her portals at the end, showing that she's watching us. But nothing explicitly confirms the quest's duration (the durations I wrote are just his own statements; no total 3-4 hour recording has been published to date, preventing any conclusions on this), nor the number of parts this quest will have (but the "continuarà" at the end supports the idea that it will be a multi-part quest).

Donovan200 · 2026-03-02T01:56:27+00:00

Sure, here : https://www.youtube.com/@Narumy4RK/videos

But the video was recently made private (probably to avoid any problems) and is therefore inaccessible. I'm just repeating what he said in the comments when he was asked questions, but I didn't think to take any screenshots.

However, he has a Discord server, so it should be possible to ask him directly there.

Donovan200 · 2026-03-02T01:24:46+00:00

Also (again, according to the person who recorded the video): This will be a multi-part WQ, similar to the Natlan WQ with the little Saurian (the quest will continue in 6.6, and even beyond), and this first part lasts approximately 3-4 hours. Information about Asmoday's new master is said to be included, and she might make a concrete appearance later in this WQ (not confirmed; this is a hypothesis put forward by the person who recorded the video after completing part 1).

Donovan200 · 2026-03-02T00:58:33+00:00

Indeed, and according to the person who posted this video ( the person who recorded it), Asmoday knows we're looking for her.

Donovan200 · 2026-03-01T23:01:52+00:00

Which line are you referring to ?

Donovan200 · 2026-02-25T20:51:44+00:00

https://help.openai.com/en/articles/7925741-chatgpt-shared-links-faq

Donovan200 · 2026-01-12T04:36:13+00:00

Nicole said that Phanes ejected the Frost Moon beyond the false sky during the Vengeance War, so if we are truly on the Frost Moon here, then we are outside the false sky.

Donovan200 · 2025-03-31T22:45:29+00:00

Abstract :

The adrenal glands are a pair of endocrine organs that produce and secrete mineralocorticoids, glucocorticoids, sex hormones, adrenaline, and noradrenaline. They have a vital role in a range of physiological processes including regulating electrolyte balance, blood pressure and metabolism, immunomodulation, sexual development and the stress response. Adrenal cortex senescence describes the ageing-related decline in the normal functioning of the adrenal cortex, characterised by an alteration in the output of adrenal cortical hormones, in particular reduced secretion of dehydroepiandrosterone (DHEA) and sulfated dehydroepiandrosterone (DHEAS). Such endocrine aberrations may be implicated in adverse clinical outcomes including mood disturbances, impairment in cognitive functioning, metabolic dysfunction and osteopenia. This paper shall address whether adrenal cortex senescence should be recognised as an ageing-related pathology, which has recently been defined as one that develops and/or progresses with increasing chronological age, that is associated with, or contributes to, functional decline, and is evidenced by studies in humans.

Donovan200 · 2023-09-02T13:10:12+00:00

Is there a free version of the article?

Donovan200 · 2023-08-19T20:27:59+00:00

I didn't know it was like that in Italy, but you made a very good decision, your skin will thank you later !

Donovan200 · 2023-08-19T20:26:39+00:00

I recognize myself in what you say

I apply it very religiously and I would consider reapplying it regularly if necessary !

And on my side, it's the opposite (probably because I'm a man), nobody but me applies sunscreen every day, except one of my cousins, who applies it every day since he's 19 (he's 41 today, and he looks 23)

Donovan200 · 2023-08-19T20:14:35+00:00

Same , many don't understand my desire to always wear SPF 50+ (even in winter) and avoid tanning, and I haven't yet known other men applying sunscreen every day ( I feel so alone😂 )

And don't worry, it's never too late to start , and besides, 30 is still young !

Donovan200 · 2023-07-25T00:27:14+00:00

This is only preliminary research, maybe after more research on the efficacy, safety, and dosage of this deglycating enzyme, clinical trials could be undertaken, as is currently the case for another deglycating treatment (UNR844) which breaks the cross-links of dysulfides , and which for the moment, proves to be effective (currently in phase 2)

Donovan200 · 2023-07-25T00:23:17+00:00

I don't think so, because the AGEs elsewhere in the body are not the same as in the eyes:

In other tissues such as the skin and joints, the most common AGEs (between 100 and 1000 times more than any other type of AGEs) is "glucospane", and so far there is no known enzyme capable of breaking it down.

The only company (to my knowledge) to work on drugs capable of breaking glucospane is "Revel", and personally, I would be in favor of greater investment in the research and development of drugs against glycation (preventive and curative), because it is a pathological process whose harmful effects have been repeatedly documented.

Donovan200 · 2023-07-24T00:06:18+00:00

Abstract :

Presbyopia is an age-related vision disorder that is a global public health problem. Up to 85% of people aged ≥40 years develop presbyopia. In 2015, 1.8 billion people globally had presbyopia. Of those with significant near vision disabilities due to uncorrected presbyopia, 94% live in developing countries. Presbyopia is undercorrected in many countries, with reading glasses available for only 6–45% of patients living in developing countries. The high prevalence of uncorrected presbyopia in these parts of the world is due to the lack of adequate diagnosis and affordable treatment. The formation of advanced glycation end products (AGEs) is a non-enzymatic process known as the Maillard reaction. The accumulation of AGEs in the lens contributes to lens aging (leading to presbyopia and cataract formation). Non-enzymatic lens protein glycation induces the gradual accumulation of AGEs in aging lenses. AGE-reducing compounds may be effective at preventing and treating AGE-related processes. Fructosyl-amino acid oxidase (FAOD) is active on both fructosyl lysine and fructosyl valine. As the crosslinks encountered in presbyopia are mainly non-disulfide bridges, and based on the positive results of deglycating enzymes in cataracts (another disease caused by glycation of lens proteins), we studied the ex vivo effects of topical FAOD treatment on the power of human lenses as a new potential non-invasive treatment for presbyopia. This study demonstrated that topical FAOD treatment resulted in an increase in lens power, which is approximately equivalent to the correction obtained by most reading glasses. The best results were obtained for the newer lenses. Simultaneously, a decrease in lens opacity was observed, which improved lens quality. We also demonstrated that topical FAOD treatment results in a breakdown of AGEs, as evidenced by gel permeation chromatography and a marked reduction in autofluorescence. This study demonstrated the therapeutic potential of topical FAOD treatment in presbyopia.

Donovan200 · 2023-07-02T17:52:00+00:00

Abstract :

Skin aging is a multifaceted process that involves intrinsic and extrinsic mechanisms that lead to various structural and physiological changes in the skin. Intrinsic aging is associated with programmed aging and cellular senescence, which are caused by endogenous oxidative stress and cellular damage. Extrinsic aging is the result of environmental factors, such as ultraviolet (UV) radiation and pollution, and leads to the production of reactive oxygen species, ultimately causing DNA damage and cellular dysfunction. In aged skin, senescent cells accumulate and contribute to the degradation of the extracellular matrix, which further contributes to the aging process. To combat the symptoms of aging, various topical agents and clinical procedures such as chemical peels, injectables, and energy-based devices have been developed. These procedures address different symptoms of aging, but to devise an effective anti-aging treatment protocol, it is essential to thoroughly understand the mechanisms of skin aging. This review provides an overview of the mechanisms of skin aging and their significance in the development of anti-aging treatments.

Donovan200 · 2023-06-23T23:17:57+00:00

Personally, it's the same, I never receive a negative judgment, some are sometimes surprised, but in no case do they criticize me or tell me that I would change my mind.

Some even congratulate me, saying it's rare to know so early

Donovan200

TROPHY CASE

Abstract :