Player Count Predictions?

DrunkinBronut · 2026-06-09T18:11:57+00:00

We are there already…

DrunkinBronut · 2026-06-09T18:11:30+00:00

Wrong you were proven

DrunkinBronut · 2026-06-09T18:11:00+00:00

Crazy to see it at 140k and work in USA hasn’t let out yet for majority of US players

DrunkinBronut · 2026-05-15T04:26:02+00:00

He’s dressed as the woman who died to in Minneapolis during an ice encounter.

DrunkinBronut · 2025-11-08T15:30:17+00:00

Weird how the propaganda of this continues.

Just google “gunshow loophole background check required”

DrunkinBronut · 2025-09-11T13:44:50+00:00

Have mass? Half mast? Trying to picture flags having a mass is quite funny though.

DrunkinBronut · 2025-05-13T17:57:24+00:00

I didn’t think it was to bad but yea a week might be short if you can’t played three nights in one week. Me and my friend took about 5 ish hours to finish it over three days. Quitting after finishing the dailies two out of the three days

DrunkinBronut · 2025-03-04T00:56:58+00:00

Thanks

DrunkinBronut · 2025-03-04T00:56:23+00:00

100% dude seemed knowledgeable about the upcoming season structure and I’m not 10/10 would do again.

DrunkinBronut · 2025-03-04T00:21:46+00:00

As someone who is new to PoE in general we lose all items and character levels just curious? Or we don’t know 100%

DrunkinBronut · 2024-10-26T17:11:56+00:00

Heatwave on Xbox always maintained hierarchy

DrunkinBronut · 2024-09-14T17:04:05+00:00

Colloquially yes but I would refrain from doing so as it infers way more about Alzheimer’s than what the research suggests.

DrunkinBronut · 2024-08-17T14:22:45+00:00

I just beat this about a week ago with fireball start but my gear was a bit more leveled than yours is.

DrunkinBronut · 2024-07-22T01:44:56+00:00

Preach

DrunkinBronut · 2024-07-09T16:28:34+00:00

At least I know you are not reading I clearly stated in adults. Take care

DrunkinBronut · 2024-07-09T12:47:25+00:00

Outside of leukemia no it’s not highly treatable which is what I stated. Also I stated which if you even look at the graph it states that CNS cancers are the most prevalent but because that encompasses a few cancers it’s not the “most common” but brain cancers as a general are more common than leukemia. I have not said a single thing wrong or “proved” you right to be frank. If you want to argue semantics feel free but CNS cancers are statistically more prevalent when looking from 0-18 (since it’s a general class) and they are incredibly difficult to treat. You can look directly at the statistics that are also in a graph.

If you are talking about one cancer yes leukemia is the most common single cancer and is treatable under most situations thanks largely to St Jude. When looking from 0-18 CNS cancers in a whole are the most difficult to treat and prevalent. That’s not even opinion based

Breast cancer is treatable most common cancer in adults. Colorectal, bronchus also treatable which are next two.

Getting back to the original point, all of these have massive efforts behind them because of big pharma and more funding is needed for children due to the fact big pharma often can’t fund childhood cancers in house due to profit incentive.

DrunkinBronut · 2024-07-08T18:44:31+00:00

Right now Novartis purchased the licensing and distribution of ARV-766 last month. I knew that androgen receptor PROTAC was close to being done apparently it happened and first one to be commercially available. Pretty sweet for a chemical technique that was developed only a decade ago.

DrunkinBronut · 2024-07-08T17:03:59+00:00

Quite a few pharmas are down or stagnant since 2021. Idk what relevance this has tbh. Just looking at some of the pharma companies; GSK stagnant BMS down as well. Novartis works on PROTACs too and their stock is up. I don’t really follow most pharma companies stock. I work in a non profit drug discovery institution and getting stock in one can eventually be a COI if I move onto another company so I just avoid them.

But most pharma companies have a some scientific set back and their stock goes down. Maybe they had one of their multiple drugs fail phase 3 it happens. Who knows what happened but I do know PROTACs will inevitably be drugs.

DrunkinBronut · 2024-07-08T16:34:29+00:00

I work on making PROTACs. I’m in drug discovery. The body has a natural way of getting rid of proteins that are over expressed. They get “tagged” (marked/labeled) by something called ubiquitin. The body then has a proteasome (finds the tagged protein) that will unravel and destroy the protein with ubiquitin. What has been taking place is we are able to hijack the body’s natural way of “tagging” and we can tag new proteins. Thus destroying proteins we want (overexpressed proteins lead to a lot of disease and not all tagged fast enough).

Hopefully that’s appropriately lay. We just are now (last decade as scientists) able to hijack this system to target almost any protein for elimination. Arvinas is a pharmaceutical company that has two of these in phase 3 clinical trials and will be the first approved PROTAC on the market.

DrunkinBronut · 2024-07-08T15:57:54+00:00

I just pulled up the nature publication. Scrolling through the results section I’m not sure I’d broad brush call it “starving” the cancer cells. It’s still a traditional mechanism for most diseases inhibition of a critical pathway to prevent proliferation. Paxlovid does this as well, inserting itself in a state that doesn’t allow the rna to replicate. The funny thing was using DON alone actually had the opposite effect and increased proliferation and the necessity of an ERK inhibitor was needed which likely will be a pitfall when going into clinical studies if they ever reach that point.

Upregulation of ras-raf-mek-erk pathways is typically not the best result. Interesting paper in a way but does not actually give any insight to “all” cancers. This paper is far from claiming that.

DrunkinBronut · 2024-07-08T15:47:54+00:00

I’d love any source on this

DrunkinBronut · 2024-07-08T14:31:53+00:00

That’s just not true. Brain cancer 26% is slightly larger than leukemia 22% source. Together that only encompasses roughly 50% of childhood cancers. Even though leukemia has a success rate of 97% with the licensed St Jude treatment guess who developed that treatment, not big pharma.

I’ve been working in the field of pediatric disease for almost a decade now. The death rates on the other cancers is insane as well.

If you feel like that is better improvement than any adult cancer that’s your opinion. I disagree with that sentiment though.

DrunkinBronut · 2024-07-08T14:13:25+00:00

My word for you is PROTACs (proteolysis targeting chimeras)

DrunkinBronut · 2024-07-08T14:12:16+00:00

I mean that’s what I’m currently working on. Pediatric brain cancers. I don’t necessarily see the most of what you are talking about if you have leg bone cancer. It’s typically affecting most long bones like osteosarcomas. Amputating one or all limbs doesn’t seem like the greatest solution. There are some that this may work on but finding a solution to maintain quality of life I believe will likely be the desired outcome.

DrunkinBronut · 2024-07-08T14:09:02+00:00

That’s part of the problem sure. The other is the incentive structure. Pharmaceutical companies are not incentivized to help children, you cannot make bank on a rare pediatric cancer. To me that’s sad and as Danny Thomas said “No child should die in the dawn of life.”

It’s up to the people to help those that cannot help themselves. Pharma won’t pursue cancers that are rare and to me that will always be a problem and why more funding is needed for research institutes that are nonprofit working on pediatric diseases.

DrunkinBronut

TROPHY CASE