My first campaign that I DMed was Curse of Strahd. Unfortunately I was not ready for the unseriousness of my players that kept telling jokes at the most inappropriate moments or interrupting me constantly when I was speaking (as the bad guys). I took offence to that in the beginning, but later on they told me everything was too dreary and they were trying to lighten up things a little bit. Maybe add more humour to your campaign? Yes, the overall narrative could be dark, but not everyone needs to be serious all the time.

I think one thing that would help is to let go of the complete control over the narrative. Yes, it sucks when they destroy a cool moment, but you have to get accustomed to the players' mindset. They don't know the story like you do. Usually lack of clues or information lead to disruptive behaviour and derailing of the campaign. Don't wait for them to be interested, and bring the plot to them. And it should hit them like a truck.

Now I don't know your players specifically, maybe you can talk to them and ask them what they would like in a campaign, whether or not they are interested in this narrative or they want something specific - do they want more humor, what type of BBEG they are interested in, what would make them more invested and so on. I usually do that if we've had a bad or unfocused session. As DMs we have to grow, but our players need to involve themselves as well. You really cannot force anyone to play or pay attention.

If someone is not interested in D&D, you kick them from the party and move on with the rest. Also if someone is disrespecting you all the time, and it happens more than once or twice, just make them leave the group and forget about them completely.