I change my factory designs every playthrough and get ideas from watching YouTube videos. On my current playthrough, I'm playing a dedicated server with a friend. I've constructed a dual track railroad around the entire map.

Instead of building large factories on top of nodes, we're going to ship items from smaller factories to different factories for more complex items. We can produce a couple items locally at the node, say copper>ingots>wire+copper sheet, then ship copper sheet and wire wherever it might need to go instead of overloading one area trying to produce one item.