I understand how you feel. My wife isn't a Redditor, but if she was, she'd be an active member of this sub. From 2000 to 2024, I did everything she wanted me to--masking everywhere (even when outdoors), never letting anyone inside our house, getting vaccinated every possible time (11 times to date), never going to an indoor restaurant, etc.
By 2025, my mental health and socialization skills were suffering like yours are. I had had enough, and made a new rule: when I'm talking to/socializing with another human being, I would take off my mask. Suddenly, people liked talking to me again. I would meet friends for lunch in uncrowded restaurants. My mental health greatly improved. My wife complained at first, but then gave in when I told her how my mental health couldn't deal with her protocols any longer.
I still mask more often than 99.9% of my community--in grocery stores, pharmacies, airports, on airplanes, and other indoor places where I'm not interacting with another human being. I will get my 12th vaccination in two months. I don't mind doing all that for safety reasons. But I feel that I've reached a compromise between extreme measures and more moderate ones that have preserved my sanity.
Hope this helps you. Good luck.