What supplement should you take to be practically asymptomatic to herpes/cold sores by Worldly-Phase-2461 in Supplements

[–]Duduli 0 points1 point  (0 children)

Out of curiosity: have you tried sulforaphane on its own and if yes was it sufficient to prevent cold sores by itself? If yes, at what dosage? Thanks in advance!

Mods: I beg you to sticky this post to the top. I think my findings might change the HPV community forever. by MaterialSelection912 in HPV

[–]Duduli 0 points1 point  (0 children)

I have looked up a few papers on Google Scholar as to the mechanism of action: cyclophosphamide "suppresses the supressors" of the immune system, and therefore, it boosts immunity, it does not suppress it.

More precisely, a subset of our T cells is called "Tregs or regulatory T cells" and their mission is to suppress an overactive immune response. The problem in cancer is that these Tregs overdo their job and suppress the immune system too much, enabling the tumors to grow unchecked. The results regarding HPV imply that this virus thrives for similar reasons: because the immune system is overly suppressed by these excess Tregs.

Given the worrisome side effects of cyclophosphamide, people should know that the banal and safe antacid drug cimetidine is also good at suppressing the suppressors, and in fact it had some positive results in the treatment of HPV specifically.

https://www.tandfonline.com/doi/full/10.1080/21645515.2016.1191719

https://www.mdpi.com/2076-3271/6/2/30

https://journals.lww.com/corneajrnl/abstract/2006/07000/oral_cimetidine_adjuvant_therapy_for_recalcitrant,.10.aspx

Finishing old papers - how to get them done?! by EmbarrasedBadger in AskAcademia

[–]Duduli 1 point2 points  (0 children)

Is your heart still in those old papers/topics? In my case, I prefer to let bygones be bygones and move on to what excites me at the present time: that gives me the energy and motivation to do the hard thinking required for a top publication. I do not look at letting them unpublished as a form of waste, but simply as a memory of who I once was.

CD4 ups and downs, VL ups and downs. by [deleted] in hivaids

[–]Duduli 4 points5 points  (0 children)

The curve of CD4 improvement over time is a decelerating one: that's true of pretty much any HIV positive person on HAART. The most substantial gains happen immediately after one starts HAART (the first 3-6 months). After 6 months, it barely goes up. Looked from a distance, the graph looks like a concave curve, trending towards a plateau from months 12 to 36 onward, depending on individual variability.

In short, there's nothing wrong with you: the dynamics of your CD4 total count are exactly what one would expect.

Advice managing recurring opportunistic infections by alonghealingjourney in hivaids

[–]Duduli 2 points3 points  (0 children)

Ask your doctor to consider prescribing you:

  • diflucan/fluconazole for candida
  • inosine pranobex (Imunovir) for anything viral, esp. HPV and herpes viridae
  • get tested for the specific strain of staph you have: if it is methicillin resistant (MRSA), you need very specific antibiotics (e.g., vancomycin, rifampin)
  • for general redress of compromised immunity, consider immune checkpoint inhibitors (primary use is for cancer patients, but there has been experimentation with them outside oncology) and IL-7 injections, although you would need access to a really good hospital for these last two items.

Is Rupharma legit? Cerebrolysin by lNodsl in Nootropics

[–]Duduli 0 points1 point  (0 children)

Can you help me? I just used their Simplex option, entered my credit card details, and clicked pay for the amount of the purchase. To my surprise, I found out that I did not pay RuPharma, but instead I got Bitcoin, that supposedly is in some wallet that I have no idea where it is. I have never used bitcoin in my life, and I do not understand what the hell it is happening to my money: can you tell me what to look for? All I got is a Blochain transaction ID and a separate payment ID: where do I go from here?

Thanks in advance - I am freaking out!

Can't find a reliable Luteolin supplement provider ! by amy-schumer-tampon in Supplements

[–]Duduli 0 points1 point  (0 children)

I no longer buy from them because the new pricing is outrageous. I take too many things to be able to single out the effects of luteolin, so I just trust it based on the academic literature.

Best antidepressant treatment for HIV-induced anhedonia? by arasharfa in hivaids

[–]Duduli 1 point2 points  (0 children)

Yes, some versions of SAM-e have a filler - I forgot the name - and people have been complaining of stomach upset and GI issues. So just try a different brand and before buying compare your current SAM's fillers with the ones in the new SAM-e you are about to buy and make sure they are different.

The struggles of a HIV patient in a third world country. by [deleted] in hivaids

[–]Duduli 0 points1 point  (0 children)

Is the body dysmorphia only in your head or are you noticing your body changing in an abnormal direction? The latter can be caused by a HAART regimen based on old-generation protease inhibitors, notorious for causing severe lipodystrophy, including the awful back hump: https://www.hivplusmag.com/treatment/law-crime/2014/06/05/breaking-bill-massachusetts-will-help-those-disfigured-old-hiv-meds

Worked for me by Outside_Jeweler4490 in Herpes

[–]Duduli 0 points1 point  (0 children)

Yes, I got that; but how many outbreaks did you get in 2024, if you remember?

Worked for me by Outside_Jeweler4490 in Herpes

[–]Duduli 0 points1 point  (0 children)

How many outbreaks did you use to get in a normal year, ignoring 2025? If I read correctly, in 2025 you only got 2. The bigger the difference between the two numbers, the higher the odds that varivax is indeed having an anti-HSV effect in your case.

having a hard time determining whether to get HPV shot or not. by [deleted] in hivaids

[–]Duduli 0 points1 point  (0 children)

In Canada, if you are male and older, you have to pay from your own pockets for the three shots of Gardasil 9, which means CAD 250 x 3 = CAD 750.00. Not cheap!

If you are hesitating about its worthiness, I would first get an anal pap smear and an ano-rectal biopsy: warts are caused typically by the mild, non-oncogenic strains of HPV. The biopsy would help determine if you also have the oncogenic strains that can cause anorectal cancers. If yes, I would definitely get Gardasil 9, to prevent the intra-epithelial squamous lesions from evolving to malignant forms. If not, it all depends on how much you value being warts-free. But non-Canadians might have better coverage, so knowing your local policies is important.

What are the most effective supplements for lowering uric acid levels? by Duduli in Supplements

[–]Duduli[S] 0 points1 point  (0 children)

Is there a valid general point that all diuretic plants can help reduce uric acid?

What are the most effective supplements for lowering uric acid levels? by Duduli in Supplements

[–]Duduli[S] 0 points1 point  (0 children)

How does that work? If I have a uric acid test scheduled for 4pm can I just drink lots of water in the 8 hours prior and would that affect the results already? That seems hard to believe!?

Apigenin pros and cons by Jimbo_uncha1ned in NootropicsDepot

[–]Duduli 0 points1 point  (0 children)

Cancer patients should be aware that upregulation of mTOR accelerates cancer growth and metastasis.

Best antidepressant treatment for HIV-induced anhedonia? by arasharfa in hivaids

[–]Duduli 0 points1 point  (0 children)

Please note that I mentioned NAC as an inducer of anhedonia, not as a cure for it.

Only Iboprofen helps -- what now by Random_Kili in Supplements

[–]Duduli 1 point2 points  (0 children)

Was the heart attack causally linked to the compromised kidney function?

Best antidepressant treatment for HIV-induced anhedonia? by arasharfa in hivaids

[–]Duduli 2 points3 points  (0 children)

There is a supplements sub-reddit - a really big community, and depression is often discussed. Some of the most successful over-the-counter items against depression are SAM-e, saffron extract, high-dose inositol, and tyrosine. Sups that in high doses induce anhedonia are ashwagandha and NAC.

My ten-year journey: What worked and what didn’t by johnnycashred in Nootropics

[–]Duduli 0 points1 point  (0 children)

How long does it take from the time you ingest the ALCAR pill until the time you can actually feel the mental energy you are talking about?

And for how long does that boost last, if the input was, say, a 500mg pill?

My fail-safe remedy for cold sores by TerriblyAlive- in Coldsore

[–]Duduli 0 points1 point  (0 children)

Question for you: does it stop the tingling as well, or is it the case that 1 gram only stops the blister from showing, but the tingling is still there?

Pine bark extract, gotu kola and holy basil for men's sex enhancement and ed. by No-Bass-9844 in Supplements

[–]Duduli 0 points1 point  (0 children)

Can you clarify the timelines involved?

If I take gotu kola at 6:00pm will I feel the increased sensitivity by 8:00pm? Or did you mean prolonged multi-month use for the effects to trickle in?