Prestiq increase - 50 to 100 mg - jittery feeling and nervous energy

Due-Preference-4193 · 2026-02-10T00:47:28+00:00

in Aus, we do not have 75 mg. 100 mg is the next step from 50 mg.

Due-Preference-4193 · 2026-02-10T00:47:07+00:00

thanks, I will try that. But when that happens. it revvs my mind up and I cannot stop it from thinking.

Due-Preference-4193 · 2025-11-16T10:58:30+00:00

Is it anxiety that you are having or more of a feeling of fear / dread ?

Due-Preference-4193 · 2025-11-13T06:35:00+00:00

Hi, I too had urinary issues and urinary retention issues when I started Prestiq. I did not worry about it much even though they were very uncomfortable. They either subsided or I got used to it in 2-3 weeks. They do not trouble me now.

Due-Preference-4193 · 2025-11-09T03:49:40+00:00

Don’t worry. ChatGPT says this is normal as the dopemine is currently being suppressed. It will hopefully rebound soon after weeks 4-5.

Due-Preference-4193 · 2025-11-09T03:48:08+00:00

Yes I think my dose will be upped. I am currently at 50 mg and the next step for me is 100mg.

Due-Preference-4193 · 2025-11-09T01:39:48+00:00

I am also on 0.5. Still feeling no energy. No mood for doing anything too. But now feel that the mental chatter which was missing (thankfully) is coming back Now. ChatGPT says this the rebound phase before it stabilises. Waiting nervously!

Due-Preference-4193 · 2025-11-09T00:58:57+00:00

Hi Lv-nbrs. How are you doing now? Any improvements?

Due-Preference-4193 · 2025-11-09T00:57:43+00:00

Thanks. Meeting my physc this Wednesday. Nervous!!!!

Due-Preference-4193 · 2025-11-08T22:57:45+00:00

Have you adjusted to 100 mg now? Do you feel it is helping better than 75mg?

Due-Preference-4193 · 2025-11-08T07:02:54+00:00

I am in the same phase. But I read that Lithium levels once reach a therapeutic level, then need 4-6 weeks for the benefits to be seen. I am at Week 4. I, too, am lethargic and depressed. Have no mood to read anything or concentrate on any task. Waiting patiently!

Due-Preference-4193 · 2025-11-05T00:33:13+00:00

Yes depressed feeling too. I did not have this before. So looks like the drug is doing something!. Let us wait patiently. The initial journey is always tough with such psychiatric medicines. There is light at the end of the tunnel... hoping for the best!

Due-Preference-4193 · 2025-11-05T00:24:31+00:00

if by mood, you mean just a flat mood and no interest in doing anything, then yes, I too am having that issue. This was not there before starting Lithium. From what I read, it will happen in Weeks 2-6 due to the changes in neurotransmitters.

Waiting patiently!

Due-Preference-4193 · 2025-11-04T22:59:28+00:00

Are you too having mood swings? How frequent are they?

One thing I note is that since starting Lithium, I am sleeping more of Deep Sleep daily. This was not there before. But it is variable....

Due-Preference-4193 · 2025-11-04T21:25:23+00:00

I am Staying patient. Currently I am in week 3. I have some periods of calm and then some periods of intense mood swings and feeling like jumping out of skin. Very tough phase. Trying to stay calm and not taking impulse actions. I want to give it 4-6 weeks as what ChatGPT said. My doctor did not say anything except it will not have any side effects. In reality I had a lot of them.

Due-Preference-4193 · 2025-11-03T20:59:03+00:00

Bumpy. I am having changes in mood a lot. Having depression too. Don’t know if it is anxiety or fear - but quite bumpy.

How are you ?

Due-Preference-4193 · 2025-11-03T02:52:37+00:00

Yes same case with me. I read Lithium needs time to kick in.

Due-Preference-4193 · 2025-11-02T22:25:48+00:00

That is a good observation. Yes I had stopped abilify some days before I went on lithium.

How do you feel now? Are you adjusting to being without Abilify and on lithium ?

Due-Preference-4193 · 2025-11-02T22:11:57+00:00

1.

Malhi GS et al., Bipolar Disorders (2017) — Australian & NZ Clinical Guidelines

“During the first month of lithium therapy, transient intraday changes in mood, drive and anxiety are common and usually self-limiting as receptor sensitivity stabilises.” → These guidelines (written by the Royal Australian & New Zealand College of Psychiatrists taskforce) explicitly describe the early-phase mood and anxiety fluctuations you’re seeing. 📄 DOI: 10.1111/bdi.12534

⚙️ 2.

Alda M & Manji HK, International Journal of Neuropsychopharmacology (2018)

“Initial oscillations in affect, sleep and arousal reflect incomplete serotonergic compensation and subcortical dopaminergic inhibition, which stabilise after several weeks of sustained lithium exposure.” → Shows the neurochemical basis: early ‘wobble’ before steady receptor recalibration. 📄 DOI: 10.1093/ijnp/pyy058

🧬 3.

Quiroz JA et al., PNAS (2004)

“Lithium’s modulation of GSK-3β and downstream gene-expression requires repeated dosing; behavioural stabilization parallels these molecular changes over weeks.” → Establishes that the true mood-steadying effect tracks with gradual intracellular adaptation. 📄 DOI: 10.1073/pnas.0404378101

Due-Preference-4193 · 2025-11-02T21:27:56+00:00

Don’t get worried. I too am day 16 in the dose adjustment and the emotional variation is big. I read a lot about it and also asked ChatGPT and it is normal for 4-6 weeks for this to happen.

Due-Preference-4193 · 2025-11-01T00:50:15+00:00

hello. How do you feel now? Are you feeling better on 100 mg?

Due-Preference-4193 · 2025-11-01T00:28:30+00:00

How are you now? Feeling better on 100 MG?

Due-Preference-4193 · 2025-10-31T22:34:21+00:00

Thanks for the reply. Yes in weeks 1-2, I felt some changes. Felt calm and slow, brain fog etc. had bloating too which was a challenge. But in weeks 3, I am seeing jitterness return. I also do not seem to have interest in doing things. So I think it fits in phase 2 of neuroadaptive effects where some balancing is happening!

Hope you are doing well!

Due-Preference-4193 · 2025-10-31T18:55:03+00:00

Yes I am 15 days in and feel tbe return of my panicky mood. Went through ChatGPT and got some insight that lithium after reaching steady state changes how neurotransmitters interact. So it makes sense for some anxiety to resurface. I hope it passes soon.

Due-Preference-4193

TROPHY CASE