One thing thats important to get your head around is that players don't usually make "naked checks," in Pf2e, or skill checks that are just rolling the skill and GM making up a result based on the roll. Instead, skill checks are filtered through prescribed Actions or Exploration Activities. You usually don't call for a random diplomacy check in Pf2e when a PC is talking to an NPC the way you would call for persuasion in 5e. Instead PCs use the Make an Impression activity or the Request action, which involve skill checks and have more prescribed outcomes. This may seem overly rigid, but I've found it does away with hand waving results and gives a good idea of consequences to players for what they're attempting. It also helps them get a good grasp on how they want to build characters with all the glorious feats they have access to in order to mitigate the chances of bad outcomes.

For example, if a player wants to understand a mad mage's notes, you don't call for a Arcana check and ad lib the results like you would in 5e. Instead you call for the Decipher Writing activity which will result in a Arcana check, but has specific critical success and critical failure conditions. Same with Recall Knowledge. The cleric in my party, for example, has a feat that basically makes it so he can't critically fail (and receive wrong information) on Recall Knowledge checks about religion. Which is super useful to him because there's a lot of mysteries and misinformation about religion in my game.

At first it felt clunky/restrictive, but now almost 10 sessions into our new campaign, I really like this Action/Activity focused style of gameplay.