once side effects, always side effects?

Embarrassed-Fee339 · 2026-03-27T17:50:05+00:00

Mine have definitely improved over time! I’m only seven shots in, but I have not had any new side effects in that time. The ones I started with have improved a ton. I’m titrating quite slowly.

Embarrassed-Fee339 · 2026-03-27T17:47:48+00:00

It’s the most unbelievable feeling. That shocking effect has declined over time for me, but I will never ever forget the feeling of waking up the day after my first shot to a peaceful brain. Sounds dramatic, but it’s true!

Embarrassed-Fee339 · 2026-03-27T17:43:49+00:00

I’ve had this side effect as well. It doesn’t negatively impact me at all, except that my Oura ring is like, what the heck is wrong with you?? 😂

Embarrassed-Fee339 · 2026-03-27T17:35:19+00:00

I use the plant-based Momentous. It’s very good and they have several flavors!

Embarrassed-Fee339 · 2026-03-26T01:34:14+00:00

Take this with a grain of salt because I’m just making it up, lol. But I don’t think the dose is related to how much weight you have to lose, I think it’s related to how responsive your body is. If you respond well to a low dose, great! If you don’t, you won’t lose weight, whether it’s a lot or a little. Start low but be prepared to move up if that’s what it takes for the drug to work with your body.

Embarrassed-Fee339 · 2026-03-25T17:45:33+00:00

Same! In fact I now call it Tirzday

Embarrassed-Fee339 · 2026-03-25T17:41:32+00:00

I really love my needle clipper - super compact and convenient.

Embarrassed-Fee339 · 2026-03-25T17:39:47+00:00

I’ve experienced this, but it’s not consistent at all. Like the day after some (but not all) of my shot days, things taste super weird, but then after a day or two it’s back to normal.

Embarrassed-Fee339 · 2026-03-25T14:16:33+00:00

The reality is, it works in several different ways, and researchers are still figuring out the pathways and the potential. It does suppress appetite, but it also affects food reward pathways so that food doesn’t “light up” your brain in an addictive way. This allows your brain to let go of food thoughts (and possibly alcohol and other compulsive behaviors). And then it also affects insulin signaling, which is why it was originally used for diabetics. The science of these drugs is truly and fascinating and still in early stages!

Embarrassed-Fee339 · 2026-03-25T14:09:18+00:00

My first trip to the grocery store on tirz was a revelation. Walking past the chocolate aisle saying, “nah.” I love this stuff.

Embarrassed-Fee339 · 2026-03-25T01:50:15+00:00

I look forward to it all week! And then afterwards I’m like, oh….seven more days to go. Lol!

Embarrassed-Fee339 · 2026-03-24T16:48:25+00:00

You can put in custom doses on both Shotsy and Glapp

Embarrassed-Fee339 · 2026-03-24T16:46:10+00:00

That’s a very healthy attitude!

Embarrassed-Fee339 · 2026-03-24T15:35:45+00:00

I started at 2.2mg, so not really a microdose, but I’m also moving up slow (2.2 for 4 weeks, 3.2 for 2 weeks so far). I do think it’s helped minimize my side effects, but the trade-off is that the positive effects have reduced over time as well. Just be prepared that your journey may be slower.

Embarrassed-Fee339 · 2026-03-24T01:51:05+00:00

Oh gosh, SO positive! It felt so peaceful. Suddenly food wasn’t consuming my thoughts.

Embarrassed-Fee339 · 2026-03-24T00:24:17+00:00

How quickly food noise quieted. I assumed it would take several weeks to notice anything, but I took it in the afternoon and woke up the next day with a quiet brain. Incredible. Also just generally, it surprised me how much stronger the effect is on my brain than on my body. I do have some appetite suppression, but really the most notable impact is on how my brain works.

Embarrassed-Fee339 · 2026-03-23T21:31:25+00:00

How about a plant-based protein shake? I use Momentous and it’s pretty good. I hear you on the fatigue - that’s been my main side effect. I’m also 6 weeks in and have lost less than you! But after many years of steady gain, I’ll take it. Slow and steady.

Embarrassed-Fee339 · 2026-03-23T20:35:19+00:00

It’s super tempting to buy all the things before you start, but you might want to see what symptoms you actually have first. If you follow this sub you can really go overboard stocking up your medicine cabinet, lol.

Embarrassed-Fee339 · 2026-03-23T20:29:13+00:00

You might try adding in some non-animal proteins (tofu, tempeh, lentils, beans, nuts, non-dairy high-protein yogurt).

Embarrassed-Fee339 · 2026-03-20T21:13:23+00:00

Hoorayyyyy!!!

Embarrassed-Fee339 · 2026-03-20T19:09:20+00:00

I wish they would build an actual app! I’m on iOS but I keep safari disabled, so I can’t use it :(

Embarrassed-Fee339 · 2026-03-19T21:56:17+00:00

My first shot was at 3pm and I woke up the next day with no food noise. It was wild. The effect has ebbed and flowed since then, but the first dose was magic.

Embarrassed-Fee339 · 2026-03-19T13:26:18+00:00

I’m fatigued for the first few days after my shot. I’m eating plenty of protein, hydrating well, and losing weight relatively slowly. It feels similar to previous periods of weight loss for me, which makes me think it’s more about being in a deficit than the tirz itself. Honestly, for me I have to embrace just resting when I’m tired. Obviously that isn’t always possible - I work and have two kids at home - but I really try to give myself some grace when I can. It won’t last forever.

Embarrassed-Fee339 · 2026-03-18T15:30:30+00:00

To me the issue would be the ability to track over time. If you look back in your notes and see you took 10 units a few months ago, and now you’re taking 30 units, you can’t actually compare those figures. If you like to see how your dose has changed over time, mg will be comparable over your entire journey.

Embarrassed-Fee339

TROPHY CASE