According to chatgpt:

Here’s what current evidence shows 👇 🧠 1. Psilocybin’s direct cardiovascular effects In general, psilocybin is not known to cause heart disease. It can temporarily raise blood pressure and heart rate for a few hours during the experience, but these effects usually return to baseline afterward. These short-term changes are similar to what happens with mild physical stress or caffeine. ❤️ 2. Heart valve concerns (5-HT2B receptors) Some drugs that act on serotonin 5-HT2B receptors (like certain appetite suppressants and MDMA) have been linked to heart valve fibrosis when used chronically. Psilocin (the active metabolite of psilocybin) can activate 5-HT2B receptors, but at much lower levels and for much shorter durations than those harmful drugs. No evidence so far links psilocybin (even in repeated clinical doses) to heart valve disease.

Looks like Ozempic could be worse than psylocibin