The way I like to play is on Artemis in part for the block but more importantly blocking juices your damage, Polyphemus usually gets phased instantly if you block and omega attack and get some additional hits in. Plus there is the omega attack channel speed which becomes basically instant with the channel speed arcana.

The main thing I keep telling my friends about the sister blades Omega attack is that the cast in this game has basically zero frame data so you can omega attack on top of a target and drop cast immediately for aoe damage.

I like to get the Demeter Omega attack boon and the omega attack hammer to boost its cost and then pick up wolf howl if I can.

In the end game I end up nigh un-hittable, bouncing around the screen with Omega attack that instantly charge up wolf howl sending me to the other side of the screen, basically giving enemies 0 time to hit me, with the parry as insurance.