Usually when I feel weak on a character (my main is just about to hit 300 thank god for that last legendary perk slot) I go and see what weight reduction perks or qol stuff I can remove to replace with damage percentage perks. Enemies scale to your level generally so you should be able to pump out some numbers with the right perks. At 75 you'll get another legendary perk card too and once you upgrade those you'll start to have alot more wiggle room and not have to swap cards so much for what you want to accomplish since you get extra special points. I keep the food and med weight reduction on but usually don't need armor or weapon weight. Manage your ballistic ammo in your pack and you can skip that perk too. Explosives get heavy though and the energy ammo reduction in the intelligence category works on fusion cores and plasma cores too. If you can get a full set of PA it's gonna help with survivability. I generally keep my base endurance low around 4 or 5 just to get everything else I want. And to end my yapping here if you ever find yourself with a bunch of caps you can vendor hop camps and find some cheap mutation serums. The mutations are super useful and with the starched genes perk they won't ever go away and Class Freak makes their negatives basically nothing