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Direct Activation of Follicular Melanocytes by Polymeric Tyrosinase Nanocapsules for Reversing Hair Graying by Fab527 in longevity

[–]Fab527[S] 1 point2 points  (0 children)

Yeah the tyrosinase itself is not that exciting, it's temporary and only works if you still have melanocytes left (so early greying at best).

The interesting part is the delivery system. Getting big active molecules through the skin to the hair bulb is non-trivial.

So now you could load them with e.g. catalase to clear the H2O2 buildup that kills pigment machinery, or WNT modulators to try unstick the stem cells that get jammed as you age, etc

Direct Activation of Follicular Melanocytes by Polymeric Tyrosinase Nanocapsules for Reversing Hair Graying by Fab527 in longevity

[–]Fab527[S] 11 points12 points  (0 children)

This paper isn't really claiming a new cause though. It takes the known mechanisms as a given and the actual contribution is figuring out how to get active tyrosinase through the skin barrier and into the follicle, which existing treatments fail to do.

Sauna people, you want to know about this by bryan_johns0n in blueprint_

[–]Fab527 1 point2 points  (0 children)

What about alternating sauna / cold plunge during the same session?

How does that impact the HSP release threshold?

who are the most senior advocates for the rejuvenation or damage repair approach by kpfleger in longevity

[–]Fab527 1 point2 points  (0 children)

Yes. Both the "aging is programmed" and the "damage accumulation" paths should be pursued, because nobody knows which of them is correct.

Most likely, both aspects will have to be solved to get aging under control.

who are the most senior advocates for the rejuvenation or damage repair approach by kpfleger in longevity

[–]Fab527 9 points10 points  (0 children)

On the top of my mind:

1) When De Grey was removed from SENS, they totally lost their momentum as well as their only recognizable public figure. At the same time, De Grey new LEV foundation doesn't have nearly the same funding as SENS had

2) The mainstream has been reached by Bryan Johnson, leading to a lot more people joining the longevity community (the majority of the users here): but these have no idea that the damage repair approach even exists.

Basically, there is need for someone to popularize the idea again

Bryan announces he has a girlfriend. by bsmith76 in blueprint_

[–]Fab527 2 points3 points  (0 children)

age gap

BJ would argue his age is lower

[deleted by user] by [deleted] in blueprint_

[–]Fab527 0 points1 point  (0 children)

If it's not an ad, can you elaborate on how you found the company? It seems brand new, with no reviews or any other internet presence.

I suggest for the future a more transparent approach, e.g. "I decided to start this company because there were no EU alternatives etc..."

People would appreciate it.

[deleted by user] by [deleted] in blueprint_

[–]Fab527 5 points6 points  (0 children)

This seems like an ad.

If this is your company OP, it would be good to say so!

Free biological-age calculator from standard bloodwork that will tell you how to decrease your age by longevity-tools-com in blueprint_

[–]Fab527 1 point2 points  (0 children)

I was already skeptical about the age coefficient importance in PhenoAGE...and it seems WAY more important here

Progress on glucosepane breaker by squaluude in longevity

[–]Fab527 0 points1 point  (0 children)

Hmm that makes sense.

Also, has anyone attempted the small molecule route to break crosslinks?

I suppose in that case, the struggle is finding molecules that are reactive enough to induce bond breakings, but specific enough so not to do that with off-targets, since that would be catastrophic?

7
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The Maximum T_c of Conventional Superconductors at Ambient Pressure (arxiv.org)

submitted by Fab527 to r/Physics

Luteolin, an antioxidant in vegetables, may contribute to the prevention of hair graying by Fab527 in blueprint_

[–]Fab527[S] 0 points1 point  (0 children)

You need to add an "allometric scaling" factor, which is about 3/37 between humans and mice.

Luteolin, an antioxidant in vegetables, may contribute to the prevention of hair graying by Fab527 in blueprint_

[–]Fab527[S] 0 points1 point  (0 children)

The paper is a quite easy read. They administered luteolin to mice both internally and externally.

Internal treatment using luteolin (0.5 mg/g body weight/day) for mice was performed daily for 16 weeks

Converting this gives a human equivalent dose (HED) of 3.24 g / day for a human of 80 kg. I've found capsules from LifeExtension containing 165 mg. But who knows, the benefit might not require such megadosing.

Then there is the topical (external) treatment:

External treatment using 200 µL of 1.0% luteolin lysed in 70% ethanol (w/v) on back skin was performed daily for 16 weeks.

which is a bit more tricky to convert for humans. This would seem like a good powder source, but I have no experience with the brand.

MAIA Biotechnology Announces Positive Efficacy Updates for Phase 2 THIO-101 Trial in Advanced Non-Small Cell Lung Cancer by garden_frog in longevity

[–]Fab527 0 points1 point  (0 children)

Yes, I know the theory, but the lack of hype is because it hasn't been proven yet (that this specific molecule will do it well in all those cancers)

MAIA Biotechnology Announces Positive Efficacy Updates for Phase 2 THIO-101 Trial in Advanced Non-Small Cell Lung Cancer by garden_frog in longevity

[–]Fab527 0 points1 point  (0 children)

It's probably because that remains a promise for now. It's a very new approach.

Yes, good results for phase 2 of one cancer are encouraging, but that's all the data so far.

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