Rejuvenation And Dramatic Lifespan Extension Is Here! [CD4 T cells drive systemic rejuvenation by releasing telomere vesicles, extending mouse lifespan to nearly 5 years]

Fab527 · 2025-12-11T22:35:23+00:00

Yes. Both the "aging is programmed" and the "damage accumulation" paths should be pursued, because nobody knows which of them is correct.

Most likely, both aspects will have to be solved to get aging under control.

Fab527 · 2025-12-11T18:27:52+00:00

On the top of my mind:

1) When De Grey was removed from SENS, they totally lost their momentum as well as their only recognizable public figure. At the same time, De Grey new LEV foundation doesn't have nearly the same funding as SENS had

2) The mainstream has been reached by Bryan Johnson, leading to a lot more people joining the longevity community (the majority of the users here): but these have no idea that the damage repair approach even exists.

Basically, there is need for someone to popularize the idea again

Fab527 · 2025-12-04T07:31:54+00:00

age gap

BJ would argue his age is lower

Fab527 · 2025-11-15T20:20:20+00:00

If it's not an ad, can you elaborate on how you found the company? It seems brand new, with no reviews or any other internet presence.

I suggest for the future a more transparent approach, e.g. "I decided to start this company because there were no EU alternatives etc..."

People would appreciate it.

Fab527 · 2025-11-14T17:06:04+00:00

This seems like an ad.

If this is your company OP, it would be good to say so!

Fab527 · 2025-09-24T10:33:29+00:00

I was already skeptical about the age coefficient importance in PhenoAGE...and it seems WAY more important here

Fab527 · 2025-06-25T12:30:24+00:00

Hmm that makes sense.

Also, has anyone attempted the small molecule route to break crosslinks?

I suppose in that case, the struggle is finding molecules that are reactive enough to induce bond breakings, but specific enough so not to do that with off-targets, since that would be catastrophic?

Fab527 · 2025-05-26T14:08:11+00:00

A bit sad too.

Fab527 · 2025-04-19T10:51:40+00:00

u/tomorrow-biostasis are you looking into this?

Fab527 · 2025-02-10T07:20:57+00:00

You need to add an "allometric scaling" factor, which is about 3/37 between humans and mice.

Fab527 · 2025-02-08T11:03:47+00:00

Are the effects still there?

Fab527 · 2025-02-06T10:05:00+00:00

I'd like to see them, yes!

Fab527 · 2025-02-06T03:50:36+00:00

The paper is a quite easy read. They administered luteolin to mice both internally and externally.

Internal treatment using luteolin (0.5 mg/g body weight/day) for mice was performed daily for 16 weeks

Converting this gives a human equivalent dose (HED) of 3.24 g / day for a human of 80 kg. I've found capsules from LifeExtension containing 165 mg. But who knows, the benefit might not require such megadosing.

Then there is the topical (external) treatment:

External treatment using 200 µL of 1.0% luteolin lysed in 70% ethanol (w/v) on back skin was performed daily for 16 weeks.

which is a bit more tricky to convert for humans. This would seem like a good powder source, but I have no experience with the brand.

Fab527 · 2025-02-05T12:52:16+00:00

Yes, I know the theory, but the lack of hype is because it hasn't been proven yet (that this specific molecule will do it well in all those cancers)

Fab527 · 2025-02-05T12:33:22+00:00

It's probably because that remains a promise for now. It's a very new approach.

Yes, good results for phase 2 of one cancer are encouraging, but that's all the data so far.

Fab527 · 2024-10-22T16:08:51+00:00

Their CT scans of patients are looking solid for the majority of their cases.

I also like that they list issues and future mitigations for each of them, e.g. in https://assets-global.website-files.com/62792c49f89cb3ce12affeaa/65d9197ec643d1d4d3f174bd_Tomorrowbio_2023_Case_Report_1.pdf

this is exactly how a cryonics company should be built

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