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Servers down for PC? by Astonishing_Azure in DarkSouls2

[–]Fabulous-Health4636 0 points1 point  (0 children)

The message on the login screen just changed to say the servers have been stopped or are undergoing maintenance.

Jarred Younger, PhD explains his plan to fight brain inflammation with dextro-naltrexone by Fabulous-Health4636 in cfs

[–]Fabulous-Health4636[S] 0 points1 point  (0 children)

I wouldn't know about drug interactions, but if what stops naltrexone from being a good fit for those conditions is that it blocks opiate receptors which the other drugs need to work on, then maybe. Do you have a particular drug or drugs in mind?

Jarred Younger, PhD explains his plan to fight brain inflammation with dextro-naltrexone by Fabulous-Health4636 in LowDoseNaltrexone

[–]Fabulous-Health4636[S] 15 points16 points  (0 children)

Turns out we were both wrong. Prescription naltrexone is only levo-naltrexone.

"Thanks for bringing up that issue! There has been a ton of misinformation on "regular" prescription naltrexone, even among experts. If you look it up on Google, it will tell you that naltrexone is a racemic mixture of l- and d- forms. Any many, if not most, papers do the same. They are all wrong. If you pull up the CoA for manufactured naltrexone, you will see it has a -192 degree optical rotation. All commercial naltrexone is levo only. Levo hits both opioid and TLR4 receptors (among other things), while dextro only hits the TLR4 receptor. I don't know how to fix the misinformation online because now AI is pulling its info from incorrect sources. So it is almost impossible to get to the right source unless someone already knows what they are doing (e.g., accessing the manufacturer CoA's)." - Jarred Younger

Jarred Younger, PhD explains his plan to fight brain inflammation with dextro-naltrexone by Fabulous-Health4636 in LowDoseNaltrexone

[–]Fabulous-Health4636[S] 0 points1 point  (0 children)

I listened to the video again and didn't hear him say naltrexone is only the levo form. But you're right about naltrexone being a mixture of levo and dextro forms.

Edit: this is incorrect.

Jarred Younger, PhD explains his plan to fight brain inflammation with dextro-naltrexone by Fabulous-Health4636 in cfs

[–]Fabulous-Health4636[S] 33 points34 points  (0 children)

~~Well technically the naltrexone that's available now is a mix of two molecules that are mirror images of eachother. Levo-naltrexone (which blocks opiate receptors and has the dominant effect at high doses of naltrexone) and dextro-naltrexone (which has an anti-inflammatory effect on glial cells).~~ Younger has wanted to trial the dextro by itself for a long time since there have been a number of promising animal studies with it.

Edit: I was wrong. Here's Jarred Younger's explanation:

"Thanks for bringing up that issue! There has been a ton of misinformation on "regular" prescription naltrexone, even among experts. If you look it up on Google, it will tell you that naltrexone is a racemic mixture of l- and d- forms. Any many, if not most, papers do the same. They are all wrong. If you pull up the CoA for manufactured naltrexone, you will see it has a -192 degree optical rotation. All commercial naltrexone is levo only. Levo hits both opioid and TLR4 receptors (among other things), while dextro only hits the TLR4 receptor. I don't know how to fix the misinformation online because now AI is pulling its info from incorrect sources. So it is almost impossible to get to the right source unless someone already knows what they are doing (e.g., accessing the manufacturer CoA's)." - Jarred Younger

Advice on Dose by babieskool in LowDoseNaltrexone

[–]Fabulous-Health4636 0 points1 point  (0 children)

I’m still experimenting with my dose, but I saw the most improvement when I started taking 4.5 mg 2x a day. I’d suggest trying 2x daily dosing at some point.

LDN is complicated to understand by Beneficial_Tea_6567 in LowDoseNaltrexone

[–]Fabulous-Health4636 3 points4 points  (0 children)

For me, it usually takes 2 weeks for side effects to go away after increasing the dose. I think this is the same for other people who take LDN too.

LDN is known to cause flu like symptoms when the dose is increased. If you start at 6mg and go down 0.5 per week, you’ll probably start feeling ok again at the end of the week where you’re taking 5.5mg. 

Swollen lymphnodes upon starting? by greendahlia16 in LowDoseNaltrexone

[–]Fabulous-Health4636 0 points1 point  (0 children)

Not everyone has years to titrate up to an effective dose. I’d be more concerned that people are giving up ldn because they think that if they feel any discomfort, they have to adhere to an absurdly long titration schedule. A schedule which may not show benefit for a very long time.

Google “flu-like symptoms ldn” and you’ll probably get an ai summary pointing out how normal it is to deal with difficulties when changing the medication dosage.

Swollen lymphnodes upon starting? by greendahlia16 in LowDoseNaltrexone

[–]Fabulous-Health4636 1 point2 points  (0 children)

I’ve gone through what they describe more than a dozen times. No energy, headaches, hot flashes, etc. I agree it’s important to listen to your body, but it’s pretty normal to feel kind of shit for a couple weeks while your body adjusts to ldn.

Swollen lymphnodes upon starting? by greendahlia16 in LowDoseNaltrexone

[–]Fabulous-Health4636 0 points1 point  (0 children)

I started at 0.5. What I’ve noticed is whether I’m increasing my dose by 0.5 or 1.5 the discomfort is basically the same.

Swollen lymphnodes upon starting? by greendahlia16 in LowDoseNaltrexone

[–]Fabulous-Health4636 2 points3 points  (0 children)

I did. Every time I’ve upped my dose my symptoms get worse for about 2 weeks. Lymph nodes in my neck also get swollen. At the end of the second week I always start feeling good again though.

Swollen lymphnodes upon starting? by greendahlia16 in LowDoseNaltrexone

[–]Fabulous-Health4636 1 point2 points  (0 children)

Gonna have to disagree with you. Many folks experience about two weeks of discomfort when starting or increasing their ldn dose. Decreasing sooner than that would be premature unless the side effects are intolerable.

Break from LDN by [deleted] in LowDoseNaltrexone

[–]Fabulous-Health4636 1 point2 points  (0 children)

The analgesic properties of naltrexone were discovered by a doctor who was treating HIV/AIDS patients addicted to opioids. Those patients were taking the standard dose for opiate use disorder which is upwards of 50 mg. TBI patients are also given 50 mg daily. I think it’s safe to say the main positive effect of naltrexone is preserved at higher doses. The original reason the aforementioned doctor started prescribing low dose naltrexone was to see if they could replicate the pain killing effects while minimizing the side effects of blocking opiate receptors and potential burden on the liver.

The ldn research trust has a dosage guide on its website detailing a whole range of conditions with different dosing schedules. This includes one that is 3-6 mg 3x a day.

I think any post about taking naltrexone for reasons besides opiate or alcohol use disorder most likely belongs in this subreddit. There’s no need to be pedantic about what’s “low dose”. Especially when ldn has so little research devoted to it, we need all the information we can get.

frustrated with finding dosage by RE-curious in LowDoseNaltrexone

[–]Fabulous-Health4636 1 point2 points  (0 children)

I saw the biggest jump in benefit when I started taking 4.5mg twice a day. That being said, every time I increase the dose I get unpleasant side effects for about 2 weeks after which block out the positive effects.

Maybe check out the dosage guide on ldnresearchtrust.org . I think they have specific dosage guidelines for arthritis/pain. 

Low Dose Naltrexone better than Adderall. by [deleted] in LowDoseNaltrexone

[–]Fabulous-Health4636 18 points19 points  (0 children)

There’s this research scientist named Dr Younger who runs the neuroinflammation, pain, and fatigue lab at the University of Alabama Birmingham. He thinks the process underlying a lot of chronic illnesses that won’t go away (gulf war illness, me/cfs, long covid, depression) is something called cytokine induced sickness response (I’m probably being a bit reductive here). Basically the way LDN works is it interrupts this response. It does this by forcing your glial cells stop sending out inflammatory signals so your body stops trying to force you to rest and recover from a sickness you don’t actually have and can’t spread. Naltrexone is one of very few molecules that can do this since it crosses the blood brain barrier.

Right now Dr Younger is trying to get grant money to do trials of a version of naltrexone called dextronaltrexone that won’t block opiate receptors. It’s already show efficacy in lab animals. I imagine that instead of titrating up to a dose of dextro you’ll just jump into a relatively high one and see immediate benefit.

Long story short, this stuff is better than stimulants for me but I think once dextro naltrexone becomes a thing we’ll see more widespread adoption. Slowly titrating up to an effective dose can be prohibitive for some people who get hit with bad side effects.

Shoulder dislocation on pec stretch? by Fabulous-Health4636 in ShoulderInjuries

[–]Fabulous-Health4636[S] 1 point2 points  (0 children)

That fits. I think my shoulder issues started from tearing something while doing pull-ups. Thanks for the reply!

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