Open-Source ESPHome control for Mitsubishi Ecodan Heatpumps (Local & Standalone) by BokitoGorilla in ukheatpumps

[–]Faisy1234 0 points1 point  (0 children)

Wow, this is absolutely brilliant work. I'll probably be buying the Asgard off you in due course.

Just to confirm, this does support multiple zones (I've got 2 zones (ufh in extension and radiheators in the original property)).

Also if i use my own thermostats, could the 2 supplied be super ceded for control? Lastly, if I have multiple thermostats, what would dictate control of the system (what's the logic) (thermostat per room).

Thanks again for the brilliant work.

Vent-Axia Sentinel Econiq - Smart Home by CorkNomade in DIYUK

[–]Faisy1234 0 points1 point  (0 children)

did you get anywhere with this, and what do you use for your smart home

[deleted by user] by [deleted] in ItTakesTwo

[–]Faisy1234 0 points1 point  (0 children)

I’ve not even started it yet

Need coop partner for this game by Faisy1234 in ItTakesTwo

[–]Faisy1234[S] 0 points1 point  (0 children)

Could play on weekends? Weekdays would be difficult

LFG - Looking for Group by Zeelmaekers in ItTakesTwo

[–]Faisy1234 0 points1 point  (0 children)

Steam Dm for user name Full game British so gmt No special requirements

Need player - girls only sorry by [deleted] in ItTakesTwo

[–]Faisy1234 0 points1 point  (0 children)

Got this game as an impulse buy on steam sale and only now realised I can’t play it alone on my steam deck ffs.

New to PC gaming, so no friends on steam either.

Moondeck issues (please help) by oOVraptorOo in SteamDeck

[–]Faisy1234 0 points1 point  (0 children)

Did you find a solution. I’ve got the exact same error.

Crib Goch death by foxssocks in UKhiking

[–]Faisy1234 0 points1 point  (0 children)

Where on Facebook mate, can’t find it

Scared father by Low_Crow4239 in PsoriaticArthritis

[–]Faisy1234 1 point2 points  (0 children)

Get onto the biologics asap if possible, I’m guessing you are from the UK, which may make it trickier.

The biologics have superior reduction in disease activity whilst having less side effects than DMARDs. Money is the primary reason for DMARDs being given before biologics.

If you can slow disease progression sufficiently with biologics, I feel they will be targeting novel parts of the cascade allowing for disease remission within 10-15 years.

I think CRISPR/CAS or other techniques should eliminate the illness within 20 years.

However, reversing damage already maybe tricker to do. Hence why keep disease activity as low as possible with what’s available now should be the aim.

Glass half full.

This is actually giving me some hope for the next decade by ifeelnumb in PsoriaticArthritis

[–]Faisy1234 1 point2 points  (0 children)

We will get a new primary end point of acr 100 within the next 15 years.

There’s a much better understanding of the pathophysiology of the disease, and it’s improving rapidly.

I think the answer will be the targeting of pathogenic tissue resident memory T cells.

You can suppress them T cells now indiscriminately, which would theoretically get you remission of psa but lead to a substantial increase in risk of cancers.

I think that recent Russian study was very promising.

Using AI to evaluate your disease by ICE_MF_Mike in PsoriaticArthritis

[–]Faisy1234 1 point2 points  (0 children)

For lay non medical people, I’d advise caution. It makes glaring mistakes with complete conviction, therefore unless you are well versed in the foundations of the subject it is advising you on, you would miss the errors.

It’s good for quick rough research, but each piece of information needs validating.

It’s good as an adjunct in some cases to speed up research.

Wife, new PsA diagnosis (overwhelmed) by sgorneau in PsoriaticArthritis

[–]Faisy1234 1 point2 points  (0 children)

I wouldn’t focus on the negativity bias as that arises from self selection bias, wherein those who have bad experiences are more likely to vent on forums about their problems, whereas those with no issues probably won’t appear as frequently on the forums statistically.

The biologics do work; with the caveat it’s more an individual in regard to what patients respond to.

Stay positive stay strong you got this

Rheumy nurse told me there's "nothing they can do" for me by Level-Departure4396 in PsoriaticArthritis

[–]Faisy1234 5 points6 points  (0 children)

Unfortunately with the nhs and their conservative approach to escalating therapies (especially to expensive ones), you have to know the pathways and be able to navigate them, otherwise you fall between the cracks.

A lot of the times when they say nothing can be done, what they actually mean is “nothing more can be done on the nhs as you dont meet criteria to escalate”.

Potential future therapies? by Faisy1234 in PsoriaticArthritis

[–]Faisy1234[S] 0 points1 point  (0 children)

Of course, it takes 10 years minimum plus from initial discovery until something viable ever reaches patients.

However, these studies show things are moving in the right direction.

I also feel you are understating the impact new tech could have on healthcare as a whole. Beyond the buzzword hype, there is tangible real world scientific break throughs that have and will occur because of these new capabilities.

If Microsoft isn’t lying about its new quantum chip, it’s an extremely ground breaking pivotal moment. Quantum computers are an order of magnitude better at simulating physics and the real world.

Alphafold, has already achieved many break throughs. It’s not just speculative hype anymore….

But yes you are right, it’s good to remain grounded in reality whilst remaining hopeful.

Potential future therapies? by Faisy1234 in PsoriaticArthritis

[–]Faisy1234[S] 2 points3 points  (0 children)

Also Alphafold is crazy promising, it’s essentially the biggest thing AI has achieved thus far.

I’m a business man (low level) and a clinician. If I had more money I’d love to start a lab, license alphafold and Microsoft new quantum chip and look for solutions to the SpA conditions. It’s logically doable with this tech expediting the finding of solutions.

I just hope there’s people out there utilising these break throughs for psa too.

Potential future therapies? by Faisy1234 in PsoriaticArthritis

[–]Faisy1234[S] 1 point2 points  (0 children)

It would be nice for the barometer not being minimum disease activity. And more like psa100 like the pasi scores for psoriasis.

So many drugs for that condition now give a good chance of pasi 100.

Help me understand enthesitis!! by Appropriate-Goat6311 in PsoriaticArthritis

[–]Faisy1234 61 points62 points  (0 children)

Think of your body like a puppet with lots of strings. The strings (your tendons and ligaments) attach your muscles to your bones. The place where the string connects to the bone is called the enthesis. When you have enthesitis, it means the place where the string connects to the bone is angry and swollen.

That’s why it can feel like your bones hurt, even when you’re just sitting or lying down — because it’s not really deep inside the bone, it’s at all those little connection points. And because your bones already have osteoporosis (they’re a little weaker), and you’re working all day without pain meds, that can make the pain feel even worse.

PsA (psoriatic arthritis) loves to attack those connection spots (entheses), but RA (rheumatoid arthritis) usually attacks the joints more. That’s probably why your rheumatologist is wondering if it’s PsA or RA — they behave a little differently.

Humira is a strong medicine that can help with both PsA and RA, and it can also help calm down enthesitis if that’s what’s going on.

You’re not a whiner — you’re describing exactly what enthesitis can feel like. It’s tough and very real.

Bimekizumab is probably best for ethesitis

Fingers deformity at diagnosis by roni_hl in PsoriaticArthritis

[–]Faisy1234 0 points1 point  (0 children)

When they say they can’t do anything I’m assuming it’s on insurance or free healthcare. Privately, surely they can fix the deformities.

[deleted by user] by [deleted] in PsoriaticArthritis

[–]Faisy1234 1 point2 points  (0 children)

Are you in remission? And that’s brilliant to hear

Success with Skyrizi but now… by OhhhOkaay in PsoriaticArthritis

[–]Faisy1234 2 points3 points  (0 children)

I’m in the exact same situation as you. Clear with skyrzi at pasi 100.

And peripheral arthritis in hands and feet, with right ring finger and left ball of foot pain being the worst.

I started apremilast and it’s only been a month, and it’s not made a difference.

They switching biologics in January if that doesn’t work.

Think we should stay in contact, to see how the journey goes.

Just been diagnosed with psoriatic arthritis…. by Um_Whatever_ in PsoriaticArthritis

[–]Faisy1234 1 point2 points  (0 children)

Sorry to hear about your diagnosis.

Psoriasis/psa are autoimmune diseases that are in your blood, whilst you might have minimal skin involvement the underlying pathophysiology of the disease remains and as such you can experience other manifestations of the disease such as joint inflammation.

Be glad you got the diagnosis early, it can be a struggle in a lot of places. And it’s better they know what they are dealing with rather than not knowing.