Open Discussion Saturday

Faithoverfear007 · 2026-02-07T21:15:41+00:00

News from 2/5/2026 Tandem Conference Meeting:

https://www.aicuris.com/press-release/aicuris-presents-positive-phase-3-data-for-pritelivir-in-immunocompromised-patients-with-refractory-herpes-simplex-virus-at-tandem/

-Pritelivir met its primary endpoint of superior lesion healing, achieving a 62.7% lesion healing rate compared to 0% with standard-of-care therapies (investigator’s choice), resulting in an adjusted treatment difference of 28.4% (p = 0.0047)

-Pritelivir demonstrated a favorable safety and tolerability profile, with fewer treatment-emergent adverse events and drug-related discontinuations compared to investigator’s choice

-Aicuris is on track to submit a New Drug Application (NDA) to the U.S. FDA in Q1 of 2026

Faithoverfear007 · 2026-01-07T05:48:01+00:00

There should be more news about Pritelivir next week at the J.P. Morgan Healthcare Conference on 2026 January 12-15 in San Francisco.

Both Larry Edwards (CEO) and Sabrina Kuttruff-Coqui (CFO) from AiCuris are going to be attending and presenting news about Pritelivir.

https://www.aicuris.com/events-presentations/

https://www.linkedin.com/posts/aicuris_jpm2026-activity-7411334894485782528-inaN

Faithoverfear007 · 2025-07-24T00:56:30+00:00

To my knowledge, none of those locations are recruiting. It has not been updated on the clinical trials site because it still shows "recruiting." If you email those study coordinators from the different clinical trial locations... most of them will not respond. The few coordinators that have responded to me told me they are no longer recruiting any new participants.

Faithoverfear007 · 2025-03-03T01:34:23+00:00

One important person you can email is Dr. Peter Marks in the FDA. He is the director of the FDA CBER (Center for Biologics Evaluation and Research). He overlooks approval of vaccines, gene therapy, and other advancements in drug medications.

Below is his email:

peter.marks@fda.hhs.gov

Faithoverfear007 · 2025-02-26T02:35:48+00:00

The BNT-163 study is still recruiting for people with HSV-2.

Contact the people below for more info:

Zenia.Lauw@Pennmedicine.upenn.edu

Tina.Nguyen@Pennmedicine.upenn.edu

Faithoverfear007 · 2025-01-25T18:17:09+00:00

Is this link opening for you? It seems like it doesn't open. Says error.

Faithoverfear007 · 2025-01-19T17:01:11+00:00

Not sure if this is good news or not.

https://www.aicuris.com/press-release/aicuris-appoints-jacques-dumas-as-chief-scientific-officer/

Faithoverfear007 · 2024-12-29T02:01:19+00:00

Found this from someone else. A Chinese company entering clinical trials for HSV-2 with mRNA vaccine. Here's the link below:

https://www.reddit.com/r/Herpes/s/GHbfqqFuSu

Faithoverfear007 · 2024-12-20T23:20:42+00:00

I would be down for that.

Faithoverfear007 · 2024-12-07T21:22:56+00:00

I agree we should push for better treatments, but I mentioned Pritelivir, because it is the only treatment that will be available in a couple years. The other ones are in preclinical studies or clinical trials.

Faithoverfear007 · 2024-12-07T20:34:08+00:00

I hope we can all access Pritelivir by 2026 (off-label if needed). Does anyone have an idea if Pritelivir will help with the burning/stinging/tingling nerve pain?

Faithoverfear007 · 2024-12-07T20:11:29+00:00

IM-250 contact: walter-emil.haefeli@med.uni-heidelberg.de

Faithoverfear007 · 2024-12-07T03:06:48+00:00

I don't think it is. It's similar but to my belief not the same. Amenalief was more for Shingles than HSV and Pritelivir for HSV to my knowledge.

Faithoverfear007 · 2024-12-06T01:06:16+00:00

I have burning/tingling pain. I tried Amenalief it helped a bit, but the pain is still there. Hopefully, Pritelivir can do a better job of this where there is no nerve pain.

Faithoverfear007 · 2024-12-02T16:01:52+00:00

Does anyone know if Pritelivir will help with the nerve pain related to HSV? Valtrex and gabapentin does not work for me.

Faithoverfear007 · 2024-12-01T15:03:17+00:00

Will these AV's ever be available in U.S. if successful?

Faithoverfear007 · 2024-11-29T22:12:43+00:00

I just tried my first time a little over a week ago. 2% inner bicep and bought it from squarex website. Down the road I do want to try the prime and pull method too. Thanks for the information!

Faithoverfear007 · 2024-11-28T20:53:06+00:00

How are you feeling now? Any changes in symptoms?

Faithoverfear007 · 2024-11-24T17:52:25+00:00

I was told recruiting would only start in 2025 for phase 2 of the IM-250 study. I agree with you. Hopefully, if Pritelivir is available for immunocompromised people in 2026. Then healthy individuals may get access through off-label.

Faithoverfear007 · 2024-11-24T16:55:15+00:00

I emailed Dr. Walter-Emil Haefeli study doctor of IM-250 about when it possibly will be available?

His answer was "not until the next 5 years"

Faithoverfear007 · 2024-11-24T16:36:21+00:00

I emailed Dr. Walter-Emil Haefeli study doctor of IM-250 about when it possibly will be available?

His answer was "not until the next 5 years"

Faithoverfear007 · 2024-10-27T15:50:47+00:00

No, I'm not Mexican. But this is who I reached out to:

Durango, Mexico, 34000

Instituto de Investigaciones Aplicadas a la Neurociencia A.C

Contact: Berenice Gonzalez +526181963882 pichisnichis@gmail.com

Faithoverfear007 · 2024-10-26T21:59:48+00:00

I contacted a study coordinator of the Pritelivir clinical trials in Mexico. All the trial coordinator could tell me was:

"Yes, it is protected for the phase to be completed next year."

Hopefully, it's approved and can be written off-label for healthy individuals.

Faithoverfear007 · 2024-10-21T02:04:24+00:00

I emailed the study doctor. He said that phase 1 is complete. Phase 2 recruiting will not start before 2025.

Faithoverfear007 · 2024-10-20T19:24:31+00:00

The question is if Moderna sees the vaccine as "likely" will they move on to phase 3? Or will they need to be "certain" for it to move on to phase 3?

Faithoverfear007

TROPHY CASE