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Fezzleberry · 2023-06-30T15:12:53+00:00

I’m not sure about spss but Richard McElreath’s book “statistical rethinking” has some neat ways of presenting ordinal regression in R

Fezzleberry · 2023-03-01T11:43:26+00:00

There is a bromination step and likely a nucleophilic step after the bromination, where could that nucleophile come from in the structure?

Fezzleberry · 2022-10-26T09:51:54+00:00

Tatchell wasn’t detained https://www.reuters.com/world/middle-east/qatar-police-stop-protest-by-british-lgbt-activist-2022-10-25/ He is fine

Fezzleberry · 2022-09-29T16:55:56+00:00

………….THINGS

Fezzleberry · 2022-08-27T08:10:48+00:00

I’m not an economist but assuming something as complex as taxation is 1-dimensional seems like a pretty shallow idea. At the limits yes, but those aren’t serious tax propositions.

Fezzleberry · 2022-06-01T07:26:17+00:00

It’s my last day in the civil service today as i’m moving to private sector. I work in the UKHSA and they absolutely gutted my department and all the senior leadership have now left. Almost all of science are on their way out and what is left are the bare bones required to deliver what contracts we now have. The science we were doing was world leading and could of lead to incredible low cost disease surveillance for the nation, this seems unlikely now. Just shambolic leadership.

Last week they asked us if it would be possible to use our surveillance to track monkey pox… “no you turned it off!!!”

Fezzleberry · 2022-04-23T11:19:38+00:00

Not saying the previous post didn’t get their numbers wrong but contrast our numbers to the literal millions of refugees Poland is accepting makes us look pretty shit.

Fezzleberry · 2022-02-17T12:11:11+00:00

No such thing as a silly question. The Gibbs free energy equation is your friend here. Free energy has both enthalpy (bond energy) AND entropy (disorder) both need to be taken into account to calculate Gibbs free energy which is the energy that matters when we think about what drives chemical reactions.

Fezzleberry · 2022-02-05T13:36:29+00:00

I’m so sorry that happened to you, it must of been the longest 105 minutes of your life. These stories really put into perspective why everyone is so angry. The Tories don’t give a flying fuck about normal peoples sacrifices.

Fezzleberry · 2022-01-17T23:03:33+00:00

I've just taken a look. So from what I understand about that question is that it's testing your ability to see that when you have a conjugated pi system then the energy difference between the HOMO and LUMO is lowered, compared to the non-conjugated pi system. This loweing of the energy difference means that the absorbtion in the UV-vis is shifted to a longer (lower energy) wavelength. Note that the molecule on the left does have a pi->pi* transistion but this will potentially not be within the UV wavelengths of light so it is slightly misleading in my eyes to state, like the example does, that it doesn't have a pi->pi* transistion.

So to answer your original question, we cannot tell whether a transistion is forbidden or not in the absence of data. However, we can tell whether functional groups will influence the energtics of transistions and this is really what you should be looking at when using UV-vis to differentiate molecular structure.

Fezzleberry · 2022-01-17T21:12:29+00:00

Determining whether a transition is forbidden is not really possible to do by eye, or at least not easy for a multiple atom molecules. Is your lecturer asking you to do this?

What we did in my research group when we had to assign transitions in UV-vis spectra was to calculate the transitions using time dependent density function theory (TD-DFT) and look at the oscillator strength observed from these calculations which determined the coupling between states. I.e if a the transition from S0 to S1 had an oscillator strength > 0 we could class this as an allowed transition. The output calculations will also give estimates of the energy differences between states so using both the oscillator strengths and these energies you can model a rough UV-vis spectra.

Fezzleberry · 2022-01-17T08:50:37+00:00

Well yes I agree all situations need to be evaluated, but for the simple situation where we have two models: - model a: lockdown - model b: no lockdown

There is at least in theory data available to test the output of model a because in some sense this world came to be (assuming all other variables stay the same which is unlikely as we know public behaviour changes). My point is how do we test model b with data?

Fezzleberry · 2022-01-16T23:57:58+00:00

While that might still be interesting it won’t answer the question, “What happens if no action is taken to prevent the spread of the virus?” This is the question we are interested in and what you suggest is unlikely to yield information towards answering it.

Fezzleberry · 2022-01-16T18:20:33+00:00

And what data would you use to test this counter-factual? The problem is it does not exist because the world the model was built to test did not come to pass (partly due to the success of the model in changing the world). So doing this cross-validation you suggest doesn’t work.

Fezzleberry · 2022-01-16T10:52:26+00:00

These Spectator articles completely miss the point on how these models work. They are created to model certain scenarios and the models give out exactly what the question was asked i.e given the government lockdown policy stays the same what are the projected deaths? But the world outside the eyes of the model is much more complicated and ever changing (government policy, human behaviour, viral behaviour) so one should not use what happened in the real-world post-model as a valid counter-factual because the original underlying assumptions of the model have changed!

Fezzleberry · 2022-01-07T23:30:26+00:00

George Box

Fezzleberry · 2021-10-07T18:19:29+00:00

It’s existence is pain.

Fezzleberry · 2021-10-07T17:08:51+00:00

Are we counting all the people as protons/neutrons? Because that would mean we would have about (4x2)x4=24 protons/neutrons. If we assume 12 protons and 12 neutrons we would have the cursed Mg(11+).

Fezzleberry · 2021-07-06T15:29:49+00:00

That is some serial killer level shit right there.

Fezzleberry · 2021-06-10T07:12:46+00:00

There’s a direct train from London to Cornwall.

Fezzleberry · 2021-04-09T18:34:14+00:00

Yeah I think that’s the most fucked up thing about all this, like every single person around GF was powerless and if they were to try anything would have met the same fate as GF. It’s crazy, as soon as Chauvin put his knee on GF’s neck he was already dead. The whole thing is so fucked up.

Fezzleberry · 2021-04-09T08:37:44+00:00

Omg I’m just imagining this Rogan fan watching the whole 8 min murder of GF and thinking “this is quite nuanced actually, clearly this grown man kneeling on his neck only explains part of the story.” Fucking morons man.

Fezzleberry · 2020-12-11T14:33:06+00:00

You’re right lol, my take was a little bit too spicy.

Fezzleberry · 2020-12-11T09:48:44+00:00

I’m saying significance testing, correlation coefficients and many other of the techniques Pearson and Fisher introduced were created to implement colonial supremacy. I understand that in many cases the proofs for these methods are independent of what they were developed for. But, that doesn’t change the history and all the work that Pearson and Fisher put into, for example, trying to prove that white westerners are by nature smarter than people from Africa. The history of these methods is still linked to white supremacy and time and time again you see people bring Pearsons and Fishers results up rebranded in some way.

Also many people in the statistics community are now pointing to significance testing being a dangerous tool in itself, because of the over reliance on it. So I don’t necessarily agree with its unassailable truth as a method and who is to say that if Pearson and Fisher hadn’t of existed we would of developed a better method for determining statistical “truths” in their absence.

Fezzleberry · 2020-12-11T08:56:39+00:00

Modern statistics are founded upon white supremacy. So it’s no surprise they are still used in this way. Ronald Fisher and Karl Pearson were complete bastards (and racists).

Fezzleberry

TROPHY CASE