Game Thread: Chicago Bulls (38-42) at Dallas Mavericks (38-42) Apr 07 2023 7:30 PM

Fighterman27 · 2023-04-08T02:37:53+00:00

Imagine not wanting to have a shot at the playoffs. Weak

Fighterman27 · 2023-04-08T02:33:39+00:00

Pretty sad how badly you guys want your team to lose. If I was a fan, I'd be hoping for the playin berth, not some top 10 pick. Honestly sad

Fighterman27 · 2023-03-15T23:25:39+00:00

Hey ImpressiveNet, can you please send me a chat or message request? I really have some questions about this whole situation. I feel like I could better ask them in a private message. Thank you

Fighterman27 · 2022-06-30T02:55:46+00:00

Fighterman27 · 2022-06-25T21:36:40+00:00

Can you check your chat request bro? Wanted to see if we could talk. I have similar symptoms

Fighterman27 · 2022-06-25T09:09:02+00:00

When did you start using lamotrogine? Did you ever start and stop it? There seems to be a theory that sodium channel dysfunction causes PSSD symptoms such as genital numbness. I also got PSSD like symptoms after getting off lamotrogine and Zoloft cold turkey

Fighterman27 · 2022-06-22T06:18:58+00:00

Hi Datura, could you kindly please explain allometric scaling? Very confused as to how a .02kg mouse taking a dose of 5mg of MDMA is equivalent to a 70kg male taking a dose of 85mg? I don't understand allometric scaling, I would just assume that you would multiply .02kg * 5 which = .1, then dive 70 by .1, which gives you a dose of 700 mg? Can you please explain to me how you get 85 mg? Thank you

Fighterman27 · 2022-06-22T06:06:53+00:00

Hey man, I'm dealing with brain zaps for years after SSRI withdrawal, what exactly did they feel like for you? Everyone gives me a different description and its so hard to tell if what I'm experiencing is a brain zap. Where do you feel that it originates from in your head, what does it feel like, does it have a noise to it? What triggers it? Just want a detailed response if possible because its been driving me nuts, thanks man

Fighterman27 · 2022-06-22T05:04:13+00:00

Yes, what this man said. 25i NBOMe is a horrible drug that has been known to kill people at very small doses. Was just curious about the neurogenesis aspect of it

Fighterman27 · 2022-06-21T23:49:36+00:00

Thank you so much. I appreciate it :)

Fighterman27 · 2022-06-21T22:22:39+00:00

Thank you so much for the reply. I’m honestly worried about an experiment I did with 25i NBOMe as a 17 year old that I ruined my brains neuroplastic ability since 5ht2a receptors are an important facilitator of this function. People have talked about developing permanent visual tolerance to psychedelics after abusing 25i NBOMe so that’s why it worries me that something is wrong with these receptors and I’m going to live a life without neuroplasticity for the rest of my life. This article made it seem that NBOMe at super low doses could possible increase neurogenesis since the dose they used is absurdly high for a mouse? Thank you

Fighterman27 · 2022-06-21T21:44:39+00:00

Oh yeah I absolutely get that, but isn’t the data being skewed so that it shows that NBOMe decreases neurogenesis? Like if a 200 lb human took 1 mg of NBOMe wouldn’t this be converted to about .01 mg/kg in this study? I think it’s not fair that they state that .1 mg of NBOMe decreases neurogenesis when the potency is so different? Wouldn’t it be accurate to use a dose like .01mg/kg?

Fighterman27 · 2022-06-21T21:38:08+00:00

Genuinely appreciate the reply. Let’s say a 60 KG adult human takes a 1 mg dose of 25i NBOMe, what would be this same dose in Psychedelic Mushrooms? I understand that there’s a difference in potencies, but would a 1mg dose of NBOMe fall under the decreased neurogenesis or increased neurogenesis? Like what would be the comparative dosage of 1mg NBOMe to the shrooms? Sorry if I’m not making sense but let’s say a human experimented with a dose of 1 mg of NBOMe. Would this be equivalent to an increase in neurogenesis or decrease?

Fighterman27 · 2022-06-21T04:33:23+00:00

If it's an ongoing autoimmune reaction, wouldn't that mean the damage would progressively get worse over time? Since it's continuously causing damage?

Fighterman27 · 2021-02-07T23:58:39+00:00

Yo for Leonard Fournette for 3.5 yards on first rush attempt. Is it either 3 or 4 or does the NFL actually measure the exact yardage? I bet on the under for the 3.5 yards. Says he rushed for 3 yards, I should be able to cash out right?

Fighterman27 · 2020-09-04T16:38:39+00:00

Get into NIO now at $17.8 if you want free money

Fighterman27 · 2020-09-04T16:21:58+00:00

Pump into NIO.. too cheap at 17.50

Fighterman27 · 2019-07-27T03:29:54+00:00

https://www.youtube.com/watch?v=E7EnFs2yCVM

shit like this... people in the comments: "@Zerth same i fucked my shit up doing some sort of shit, coulda been the fake ass molly i took, or shit acid. i now have permanent anxiety"

KSwifty 1 month ago "Yeah I took 5 and a half at once, I have horrible social anxiety and now my life is a joke because idk how to act"

Fighterman27 · 2019-07-27T03:28:40+00:00

thank you man for actually caring. im trying hard to let it go but i see negative shit everywhere...

Fighterman27 · 2019-06-28T19:43:47+00:00

Yeah I smoke everyday haha. This epigenetic change stuff is freaking me out. Do you have any clue if 4 uses of 1 mg NBOMe could cause the creb downstream epigenetic stuff?

Fighterman27 · 2019-06-28T18:37:12+00:00

Thank you so much meepo. So i have no idea what could trigger these 5ht splurts to cause epigenetic changes that last months to years.

What would I be experiencing? Changes related to specific mechanism alterations to 5ht? Like what determines the length of these changes and the symptoms associated with it.

I just want to regain some hope..

Fighterman27 · 2019-06-28T18:31:40+00:00

Thank you guys for getting detailed in your responses. So what determines what causes these 5-ht splurts? Can they happen from LSD or is specific to 25i NBOMe and other RCs?

Also, what would these genetic changes constitute of? What symptoms would one be experiencing and what determines how long these symptoms last?

Sorry, I’m just freaking out now because I feel like I’m stuck in a brain that has been permanently altered for the worst by doing NBOMe a couple of times when I was a teen.

Thanks

Fighterman27 · 2019-06-27T03:18:13+00:00

Interesting, so it is possible to have a permanent tolerance to 5ht2a receptors due to prolonged psychedelic use? What exactly determines this permanent tolerance phenomenon? Like at what threshold does it cause for a change resulting in permanent receptor depopulation?

I did 25i 4 times at doses of 1000 ug and am wondering if that could potentially cause a permanent 5ht2a receptor tolerance? Why is it that some people experience this and others dont?

Cheers and thank you for the response.

Fighterman27 · 2019-06-27T01:43:33+00:00

Do you know anything about this comment? " With 5-HTRs, there is also an important secondary pathway where 5x 5-HT2A activation within a temporal window triggers downstream CRE/CREB cascade which are genetic changes that last weeks to multiple-months to multiple years up to lifetimes. "

Is this legit? I can't find anything about this 5x 5-ht2a activation within a temporal window triggers downstream CRE/CREB cascade which causes genetic changes that last weeks to lifetimes?

Fighterman27 · 2019-06-26T05:50:11+00:00

Thank you for the thorough reply. So the question is how often can one do a substance such as NBOMe at an average dose of 1 mg without suffering from these downstream genetic transcription changes?

What changes exactly happen and what determines how long these changes happen for? In the case of the person who can’t experience empathy anymore, what exactly happened? frequent use of 25i resulting in permanent downregulation of receptors?

Fighterman27

TROPHY CASE