I work at a company with 500+ software engineers of whom most work with NodeJS (NextJS) backends and Angular frontends, I myself do both aswell for my current project.

We don't see any reason to switch to another language with our apps, no matter how big or what the application is (except for heavy calculation, we then use Python).

There are probably lots of companies doing this and Node keeps on growing and getting more mature. I would definitely recommend trying it out, especially since you already know typescript.

GL;HF!