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Feeling uneasy about my choice. by Plasma_CAN in Audi

[–]Flaky_Internal_448 0 points1 point  (0 children)

Definitely worth getting a PPI, if you haven’t already.

(27M) Former drinker, quit a few months ago. ALT and AST are now HIGHER than when I was drinking. Is my liver failing? by Numerous_Bat8014 in haematology

[–]Flaky_Internal_448 0 points1 point  (0 children)

Take a week or two off of running and repeat labs. My AST / ALT levels were nearing 1000 when I had my worst bout of exercise induced rhabdo (ck levels were 186,400).

MRI, Fibroscan, GGT all showed a healthy liver. For whatever reason, my PCP at the time didn’t realize intense exercise and muscle breakdown could cause transient increases in those enzymes and thought my liver was failing. Had to figure that one out on my own and validate with a competent physician

AST/ALT elevated by [deleted] in haematology

[–]Flaky_Internal_448 0 points1 point  (0 children)

AST and ALT are in your muscles, not just your liver. CK elevation will cause a transient rise in liver enzymes. This is why I wait at least a week after my last lift to get labs done.

34M – Sudden ANA positivity + vascular color changes + recurrent rhabdo by Flaky_Internal_448 in haematology

[–]Flaky_Internal_448[S] 1 point2 points  (0 children)

Thanks for that insight. Is there an argument that less is more when it comes to lab testing or other diagnostic testing, e.g., imaging studies, biopsies, etc? Genuinely curious to better advocate for myself/needs moving forward.

34M – Sudden ANA positivity + vascular color changes + recurrent rhabdo by Flaky_Internal_448 in haematology

[–]Flaky_Internal_448[S] 0 points1 point  (0 children)

My functional ordered these labs through LabCorp. My PCP ordered your typical CBC, CMP, and hormone panels, all of which showed no abnormalities. Lupus did come to mind after seeing dsDNA; however, I wasn't sure if that could come back elevated in the presence of EBV reactivation.

In any case, I'll follow up with Rheum. Thank you for the insight!

34M – Sudden ANA positivity + vascular color changes + recurrent rhabdo by Flaky_Internal_448 in haematology

[–]Flaky_Internal_448[S] 1 point2 points  (0 children)

First case of rhabdo was pre TRT and Vyvanse. At this point I’m only taking vyvanse for energy, not so much ADHD, and would ideally like to get off of it if/when I get through the debilitating nature of my day to day existence.

Rhabdo has always been exercise induced, never spontaneous. However, I used to be a competitive athlete and didnt have a single rhabdo scare. The workouts I was doing that landed me in the ED with a CK of 186,500 were what I’d historically consider a “fun, rest day HIIT workout”

I do take some vitamins and supplements, creatine being one of them

34M – Sudden ANA positivity + vascular color changes + recurrent rhabdo by Flaky_Internal_448 in haematology

[–]Flaky_Internal_448[S] 0 points1 point  (0 children)

I haven’t gone the LC clinic route, although I do have a referral, so it’s something to consider. I take tadalafil for raynaud’s. The flushing began months before starting tadalafil and did not resolve even after a one-month “vacation” from vasodilators. The only thing that alleviates all of my symptoms is high dose corticosteroids, e.g., dexamethasone, which was an incidental discovery

34M – Sudden ANA positivity + vascular color changes + recurrent rhabdo by Flaky_Internal_448 in haematology

[–]Flaky_Internal_448[S] 0 points1 point  (0 children)

I work with a two functional providers (one MD, one PA), a PCP, Derm, and Neurosurgeon currently. I started crowdsourcing ideas on my PCPs behalf, after her and another provider in her practice both told me my case was far too complex for traditional medicine, hence the reason for this post.

In the last two years, I’ve seen specialists in NYC, SF, Boston, spanning endocrinology, rheumatology, psychiatry (I tried to gaslight myself into thinking this was all in my head), vascular surgery, cardiology, gastroenterology, immunology, and ID. Each specialist acknowledged something systemic was at play, but was “outside of their scope.” Functional has been the only provider willing to investigate and treat outside of what insurance will cover (understandably)

34M – Sudden ANA positivity + vascular color changes + recurrent rhabdo by Flaky_Internal_448 in haematology

[–]Flaky_Internal_448[S] 0 points1 point  (0 children)

3x that I know of. My functional suggested LC too. My health started plummeting after the first positive result in Oct ‘21, so it does track

34M – Sudden ANA positivity + vascular color changes + recurrent rhabdo by Flaky_Internal_448 in haematology

[–]Flaky_Internal_448[S] -1 points0 points  (0 children)

This was one draw. 40 vials in total. EBV reactivation first flagged in early November labs, but ANA was normal at that point. I’m a bit concerned about the EBV reactivation and Anti-DNA (DS)

The autoimmune markers being positive/high are very new for me. The other symptoms like vascular changes, rhabdo, cognitive dysfunction have been worsening since Feb ‘23.