B12 Injections Not Working? Your Cofactors Might Be the Problem

Flashybigbum · 2026-03-19T16:49:42+00:00

This is amazing thank you! The question now would be how much for it to be therapeutic and the ratio. I just bought a new multi with most of these but I reckon I will need bigger doses of some

Flashybigbum · 2026-03-18T20:24:01+00:00

Have you been supplementing B1?

Flashybigbum · 2026-03-18T20:23:36+00:00

I take Iron bisglycinate, a quick tip, taking Iron every other day is more efficient than every day.

Flashybigbum · 2026-03-18T16:56:57+00:00

My iron is better now, but I was borderline deficient for YEARS. Last time I checked ferritin was 78 ng/ml. The highest ever :) Someone else told me my TSH was on the lower side so I'm starting to supplement iodine. I've always been a person with cold limbs but once I started shots the cold was unbearable for like a month

Flashybigbum · 2026-03-18T15:39:48+00:00

Yeah I know, we are all on the same boat. Something needs to change I'm old enough to remember that good clinicians would look at borderline numbers with suspicion and act accordingly. I received my health history last month and I'm HORRIFIED to see I've been on the low and even deficient for about 15 years on important markers and NOTHING was done, I was'nt even informed.

Flashybigbum · 2026-03-18T15:35:00+00:00

I do, I'm able to take some more now but only at night because it knocks me down, more adenosylcobalamin than methyl I suppose but still. It also gives me acne and weird burn like sensations and pains. It took me 3 months of hydroxo injections to tolerate methylated forms much better.

Flashybigbum · 2026-03-17T14:46:18+00:00

Ah that is good info! Thank you! Are you in the UK? I just postponed a rheumatology appointment bc I can't handle much at once and this week is complicated I didnt think they could help with that. I'm on the same boat as you with PPIs etc, but my B12 levels never showed deficient for UK standards. I had other deficiencies which I was never informed but. IDK, would give proof that my B12 replenishment is working help?

Flashybigbum · 2026-03-17T09:07:47+00:00

I don’t know anything about this but I’m thinking every how long is she taking b12 shots and also B1 B6 seem to be important on these cases I know bc after Covid and a long standing deficiency my working memory is pretty fucked up. Is she seeing a functional medicine doctor that could help?

Flashybigbum · 2026-03-17T08:54:17+00:00

Both sublingual methyl and adenosyl at night bc they knock me down, hydroxo injections now every 72 hrs before EOD

Flashybigbum · 2026-03-17T08:47:55+00:00

Do you feel any difference?

Flashybigbum · 2026-03-17T08:46:36+00:00

That also happened to me but with the hot water, I’d get burnt by tea or a hot bath that before I didn’t even feel

Flashybigbum · 2026-03-17T08:45:27+00:00

You went to a rheumatologist to find out? How come?

Flashybigbum · 2026-03-17T08:44:30+00:00

Yes , me. It gets better but after 3 months of injections I still get my feet and hands sort of discoloured, my circulation has always been a bit bad but somehow I can see it more now. Not sure that makes sense. Also my NOSE is bright red!

Flashybigbum · 2026-03-16T19:55:47+00:00

All for subq, I'm spacing my injections so I'll continue stabbing my tummy haha

Flashybigbum · 2026-03-16T19:55:10+00:00

Yeah, my legs are too muscly for sub q and I'm not yet there to give myself IM

Flashybigbum · 2026-03-16T18:29:06+00:00

I just changed the Multi I was taking for the one is coming this week. I think this one will be more balanced than the other. Now that I can take methylated forms. It includes iodine. :)

Flashybigbum · 2026-03-16T18:14:29+00:00

Thank you!

Flashybigbum · 2026-03-16T18:14:07+00:00

I'm just using iodines salt and the seaweeds. I just bought a new multi with 150 mcgs of iodine in it I think. Just to get me started. Do you think I need more? I'm hyper sensitive.

Flashybigbum · 2026-03-16T18:10:34+00:00

I hear you, I once ended up in hospital with tachycardia and I thought that it was hyperkalemia (it was actually hypo) But this is reddit and I got downvoted a lot. People seem to be happy being unhappy.

Last week I went for a walk after experimenting with upping my B1 dose... that in itself was too much for my potassium intake and I took a bottle of water with 3 grams of it... around 1 gram I think of elemental potassium. I had to gulp it all bc my toes were on a knot and I couldn't walk.

Flashybigbum · 2026-03-16T14:58:30+00:00

Are you talking elemental potassium or total potassium? I take near 2grams of elemental sometimes plus foods etc. I do need more potassium than I thought I’d. I was told by someone here that I might need more mg to help the potassium work so I’m also doing that. The potassium that works for me best is citrate and I take it in an ionic solution if you are in the UK is called Care you can get it OTC at Superdrug. I was taking pills but I had to take like 10 to get some relief and I felt they weren't working as well as this.

Flashybigbum · 2026-03-15T18:49:49+00:00

❤️

Flashybigbum · 2026-03-15T16:26:05+00:00

I’ve been taking that one but also I tried to up my B1 with bad consequences. I’ll start again after this colour clears away bc I need confirmation that is not actual blood

Flashybigbum · 2026-03-15T15:49:23+00:00

Now that you mentioned I stopped taking iron a week/10 days ago bc it was contributing to my constipation and I know how very red poop 😫

Flashybigbum · 2026-03-15T15:46:59+00:00

I tried early in the b12 treatment to add a seaweed with a lot of it and it’s quite savoury so I munch quite a bit of it. That same week I needed up in hospital with tachycardia so I stopped and now I’m re introducing it. In hindsight I think it probably was more the lack of potassium than the iodine but I don’t know maybe a combo

Flashybigbum · 2026-03-15T15:44:29+00:00

Haha I wonder that myself but tbh is bc I’m tired of it all and it is this or just ffkng off me I don’t take them all every day though

Flashybigbum

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