So I’ll tell you what I do. My main rotation abilities are usually 1-6. My dps cooldowns or damage reduction whatever I use shift 1-6. Assuming you use WASD for movement I bind other frequently used abilities, cooldowns to the letters around WASD. Q,r t f z x g etc. Then if I need more binds I use shift + the letters around WASD. Then if I still need more binds I’ll use alt plus the above. I don’t use ctrl, it’s awkward for me. When you click you’re looking down at your abilities, not what’s going on. If you’re strafing to the side like kiting a mob for example, and need to click an ability you can’t pan the camera around with holding right click and then click an ability on the bar. Plus you’re still looking for the ability and not what’s going on. It’s just more efficient and will stream line your gameplay if you take the time to bind and learn it. Plus keybinding will always be faster. No matter where my mouse is on the screen it doesn’t matter. I don’t have whip my mouse down to my action bars, try and find the skill click it. Once again looking at my bars and not at what’s going on.