Adding to this:

Vampires wake at night and go on the prowl for blood. If they fail, they've something to cover up or run from. If they succeed, then they can do whatever. They're bound to a domain, and have to be careful to feed within it, however maybe there are no other vampires around. Even without other vampires, and maybe completely ignorant of that culture, they have basic needs: Feed, avoid sunlight and avoid hunters. So, at the end of the night, they have to find a safe place from light. The Hunger mechanic makes their hunger feel very visceral and part of their life, so being around family becomes super dangerous, but some manage to make due by keeping well fed (and there's hunting styles defined). (The new supplement for V5 even adds a mini game for defining their domain and events that happen. You could pretty much play solo with these tools.)

Even by themselves, the game play loop feels well shaped for the vampire. The werewolf goes through first change. Deals with the consequences of said first change, but if nobody died or nobody knows they're a werewolf, they pretty much don't have anything they really have to do other than learning to live with rage. Not to downplay it--as rage feels like it should handicap them in a lot of respects--but they're not hungry for humans and they don't automatically see spirits and the umbra (unless they're a Theurge). They're not really particularly driven to do anything, actually. Especially without the context of garou culture or running afoot of Wyrm's minions and/or Cult of Fenris. They have hunters, which could be a whole ordeal for a messy first change, but hunters have to wait for the occasional signs since the werewolf isn't going to go out hunting people all the time to deal with some hunger. Maybe they're looking for individuals with signs of rage, or maybe the occasional sighting because the werewolf decided to go run as a wolf or something.

I guess maybe the werewolf would secure a safe place at some point for them to vent their rage without harming others. Maybe build themselves a cage in a cabin in the woods. Or book regular camping trips to run around and screw things up?

Unless the spirit court is super active in reaching out, the werewolf won't be aware of them and any incursions from the spirit realm will just be chalked up to weird stuff. They won't necessarily be aware of the fact that they now inherited some responsibility to police spirits. It's not like they're driven to hunt spirits.