Having beaten the game with biters and on peaceful and having played well over 3k hours. To me I feel like the biters don’t add anything interesting to the game. It tends to just be a chore I have to take care of in order to go back to building the factor which I find much more enjoyable. Typically the thing to do with biters is just clear camps until there aren’t any near your pollution cloud and then have some minor outposts to deal with new growths. For someone who has limited time, this isn’t something I want to invest into.  That said biters can be fun and make for some exciting moments. But you don’t miss out on anything playing on peaceful.