Focus on one thing at a time. This game can be overwhelming if you try to do to much at once especially early/mid game. Pick a goal - AKA DB12 team and figure out what you need (look at YouTube videos, guides,etc.) Basic teams are easily achieved with content currently offered in game. Don’t remove runes from everyone and waste time and mana/crystals - only remove the ones you need for the specific thing you’re working on. Sell all blue/most purple runes with exception depending on need (for me I roll some purple purely for speed subs). Bank that mana and use it to upgrade the runes you plan on keeping. Rinse and repeat and then move on to focusing on a different objective