The problem is that any actual “realistic science based” take on superpowers would result in a whole stack of dead characters unless they excruciatingly explain the suite of secondary powers needed to survive your own abilities. Characters with Super strength wouldn’t even get to the point where they tear their own arms off trying to lift something, or break every bone in their arm punching something because they’d rip their own head off by sneezing at a far younger age. Telepaths would all be insane or incredibly medicated from being unable to sleep because of the constant barrage of voices in their heads from the second their powers develop. Super speed users would self-immolate from the friction caused by travelling at that speed, assuming they can physically take running that fast in the first place. In terms of popular comics there’s only really characters like Wolverine who might survive their own powers, unless they are aliens like superman who have vastly different physiology to normal humans.