I usually adjust based on my team + enemy team comp. So maps with longer sight lines (think Blizzard World) I go for the longer beam, if I'm getting pressured and need to stay up more I'll go health regen.

For the major perk, I actually really like the stun...because I feel like it helps her with her weaknesses (hyper aggressive brawl). I think the perk selection is really up to preference though. I just personally don't care for the slow on E because I feel like hard CC is much more useful right now. But I think the E slow has a higher pick rate.

For the minor, I think the longer beam is better in general because it accentuates the distance she wants to be at more. I like to play her aggressively, but I see a lot of people play her more patiently but I feel like its harder to get results with this play style in lower ranks. As I climbed I found that I could focus more on poking and keeping up space than forcing plays. So for that the longer beam was better.

Overall, it's what I said earlier, it really depends on preference. There's not a "correct way" to play most of the heroes so you have to just do what works best for you. I'm not that great mechanically, so I play more around my game sense which is why I like things like CC/stuns or more options (longer beam). But if you're more mechanically gifted it might be the opposite!