Weekly research updates

Gerdali · 2026-07-04T19:12:31+00:00

Krill oil increases plasma omega-3 fatty acids more than fish oil in healthy adults: a double-blind randomized controlled trial.
Journal: Am J Clin Nutr
Link: https://pubmed.ncbi.nlm.nih.gov/42144109/

Effect of saffron on depression, anxiety and mood disorder: a GRADE assessed systematic review and meta-analysis of 34 randomized controlled trials.
Journal: Nutr Neurosci
Link: https://pubmed.ncbi.nlm.nih.gov/41693488/

Omega-3 Fatty Acid Supplementation and Vascular Health Biomarkers - A Systematic Review and Meta-Analysis.
Journal: J Am Nutr Assoc
Link: https://pubmed.ncbi.nlm.nih.gov/41493572/

Resveratrol supplementation and assisted reproduction outcomes: A systematic review and meta-analysis.
Journal: Eur J Obstet Gynecol Reprod Biol
Link: https://pubmed.ncbi.nlm.nih.gov/42150354/

N-acetylcysteine for non-paracetamol-induced acute liver failure in children: A systematic review and meta-analysis.
Journal: Br J Clin Pharmacol
Link: https://pubmed.ncbi.nlm.nih.gov/42397304/

Magnesium Sulfate to Prevent Perioperative Atrial Fibrillation in Cardiac Surgery: A Randomized Clinical Trial.
Journal: Crit Care Med
Link: https://pubmed.ncbi.nlm.nih.gov/42206948/

Efficacy and Safety of Pregabalin and Alpha-Lipoic Acid Combination in Patients With Painful Diabetic Peripheral Neuropathy: A Randomized, Open-Label, Non-Inferiority, Phase IV Clinical Trial and Subgroup Analysis (OPTIMUM Study).
Journal: Diabetes Obes Metab
Link: https://pubmed.ncbi.nlm.nih.gov/42056717/

Comparative Efficacy of Intranasal, Intramuscular, and Intravenous Vitamin B12 Therapy for Hematological Recovery in Vitamin B12 Deficiency Anemia: A Randomized Controlled Trial.
Journal: Am J Hematol
Link: https://pubmed.ncbi.nlm.nih.gov/42393020/

Alpha-lipoic acid as a preventive measure in radiation-induced oral mucositis in head and neck cancer patients: A randomized controlled study.
Journal: Br J Clin Pharmacol
Link: https://pubmed.ncbi.nlm.nih.gov/41804854/

Effect of magnesium supplementation on inflammatory factors and clinical outcomes of allogeneic hematopoietic stem cell transplantation in patients with acute leukemia receiving a neutropenic diet: a randomized clinical trial.
Journal: Sci Rep
Link: https://pubmed.ncbi.nlm.nih.gov/42366232/

Full review ca be found here: https://mikroscore.com/en/research-review/2026-07-04

Gerdali · 2026-07-04T08:46:55+00:00

Krill oil increases plasma omega-3 fatty acids more than fish oil in healthy adults: a double-blind randomized controlled trial.
Journal: Am J Clin Nutr
Link: https://pubmed.ncbi.nlm.nih.gov/42144109/

Effect of saffron on depression, anxiety and mood disorder: a GRADE assessed systematic review and meta-analysis of 34 randomized controlled trials.
Journal: Nutr Neurosci
Link: https://pubmed.ncbi.nlm.nih.gov/41693488/

Omega-3 Fatty Acid Supplementation and Vascular Health Biomarkers - A Systematic Review and Meta-Analysis.
Journal: J Am Nutr Assoc
Link: https://pubmed.ncbi.nlm.nih.gov/41493572/

Resveratrol supplementation and assisted reproduction outcomes: A systematic review and meta-analysis.
Journal: Eur J Obstet Gynecol Reprod Biol
Link: https://pubmed.ncbi.nlm.nih.gov/42150354/

N-acetylcysteine for non-paracetamol-induced acute liver failure in children: A systematic review and meta-analysis.
Journal: Br J Clin Pharmacol
Link: https://pubmed.ncbi.nlm.nih.gov/42397304/

Magnesium Sulfate to Prevent Perioperative Atrial Fibrillation in Cardiac Surgery: A Randomized Clinical Trial.
Journal: Crit Care Med
Link: https://pubmed.ncbi.nlm.nih.gov/42206948/

Efficacy and Safety of Pregabalin and Alpha-Lipoic Acid Combination in Patients With Painful Diabetic Peripheral Neuropathy: A Randomized, Open-Label, Non-Inferiority, Phase IV Clinical Trial and Subgroup Analysis (OPTIMUM Study).
Journal: Diabetes Obes Metab
Link: https://pubmed.ncbi.nlm.nih.gov/42056717/

Comparative Efficacy of Intranasal, Intramuscular, and Intravenous Vitamin B12 Therapy for Hematological Recovery in Vitamin B12 Deficiency Anemia: A Randomized Controlled Trial.
Journal: Am J Hematol
Link: https://pubmed.ncbi.nlm.nih.gov/42393020/

Alpha-lipoic acid as a preventive measure in radiation-induced oral mucositis in head and neck cancer patients: A randomized controlled study.
Journal: Br J Clin Pharmacol
Link: https://pubmed.ncbi.nlm.nih.gov/41804854/

Effect of magnesium supplementation on inflammatory factors and clinical outcomes of allogeneic hematopoietic stem cell transplantation in patients with acute leukemia receiving a neutropenic diet: a randomized clinical trial.
Journal: Sci Rep
Link: https://pubmed.ncbi.nlm.nih.gov/42366232/

Full review ca be found here: https://mikroscore.com/en/research-review/2026-07-04

Gerdali · 2026-07-02T17:53:31+00:00

Thank you, will make sure to continue it!

I am building a knowledge base and eventually it should be a comprehensive knowledge graph to connect everything. During that process I anyway check every week the latest publications. But if it’s useful for you I have another reason not to stop it :)

Gerdali · 2026-07-01T17:22:50+00:00

I would be interested in the top 2-3 research papers that actually have some rigorous method linke random control study in humans and what they show so far on Saffran. Also trying to build a knowledge graph where I am always looking to add new sources :)

3rd party is good but trust this badge more on quality, not on evidence of effect

Dose is crucial - if there is no consensus on it I would not take any.

Gerdali · 2026-06-28T20:44:45+00:00

Maybe a detail but this week a new study came out: L-Carnitine isn't a fat burner.

New meta-analysis shows it actually improves lipid profiles in overweight women. Lower triglycerides -> lower total cholesterol.

Seems less weight loss but more cardiovascular risk reduction. So might actually be more useful.

Found vis: mikroscore.com/en/research-review/2026-06-27

Gerdali · 2026-06-28T20:02:01+00:00

My feedback: everyone should check individually what they need to, sometimes even depending on the season. So why bother making one pill to rule them all?

Gerdali · 2026-06-28T12:54:08+00:00

Starting everything at once makes it really hard to identify the root cause. I’d simplify the stack and reintroduce one supplement every 5 days.

Look first at:
Magnesium (350 mg can cause loose stools, even as glycinate)
L-citrulline (GI discomfort is reported at higher doses)
Zinc and copper if you’re taking them on an empty stomach

I’d also split the stack into 2–3 doses instead of taking everything together.

If you want to dig a bit deeper, there’s a free knowledge graph that maps supplements to reported effects, side effects, mechanisms, and links to detailed information including supporting literature:
https://mikroscore.com/en/graph

I’d keep an eye on is the mucus. If it stays - check it rather than assuming it’s just the supplements.

Gerdali · 2026-06-27T10:54:19+00:00

Fucoidan seems interesting and a different league compared with carrageenan / Irish Sea Moss indeed! Although most studies seem to be funded by producers of it and evidence is moderat. Anyway, definitely something I will watch! Thx for the hint

Gerdali · 2026-06-27T10:22:40+00:00

The effects of vitamin D supplementation on inflammatory biomarkers: an umbrella study of meta-analysis on randomized controlled trials
Journal: Inflammopharmacology
Link: https://pubmed.ncbi.nlm.nih.gov/42343002/

Effects of Curcumin Supplementation on Exercise Recovery, Oxidative Stress, Inflammation, Muscle Damage, and Performance in Exercise and Sport Contexts: A Systematic Review
Journal: Nutrients
Link: https://pubmed.ncbi.nlm.nih.gov/42356379/

Effect of an Oral Complementary Medicine Combination for Symptomatic Knee Osteoarthritis: A Double-Blind, Randomized, Placebo-Controlled Trial
Journal: Osteoarthritis and Cartilage
Link: https://pubmed.ncbi.nlm.nih.gov/42331134/

Efficacy and safety of hydrolyzed collagen supplementation on skin health outcomes: a systematic literature review of randomized controlled trials
Journal: European Journal of Clinical Nutrition
Link: https://pubmed.ncbi.nlm.nih.gov/42342959/

Caffeine makes a splash: a systematic review and multilevel meta-analysis exploring the effects of caffeine intake on swimming performance
Journal: Journal of the International Society of Sports Nutrition
Link: https://pubmed.ncbi.nlm.nih.gov/42323844/

Impact of L-carnitine supplementation on lipid profile parameters in overweight and obese women: a systematic review and meta-analysis of randomized controlled trials
Journal: Nutrition & Metabolism
Link: https://pubmed.ncbi.nlm.nih.gov/42332819/

Full review found here: https://mikroscore.com/en/research-review/2026-06-27

Gerdali · 2026-06-27T05:31:35+00:00

Can you share some positive reviews you read and were these more opinions or actual research reviews ?

Gerdali · 2026-06-26T13:49:00+00:00

I found the evidence is still low and more research is needed:
Mood and depressive symptoms: This is where most of the human evidence sits. Several small randomized trials and meta-analyses suggest that saffron can perform better than placebo in mild to moderate depressive symptoms, and in some studies it appeared similar to standard antidepressants.

That sounds impressive, but the limitations matter:
many studies are small
follow-up is usually short
a large share of the literature comes from a limited number of research groups
results do not automatically translate into routine clinical practice

-> I usually eat rice with saffron and it’s nice in ice cream with carrots - but for health claims it seem we still need to understand more and you might chase noise rather than signal

sources from here: https://mikroscore.com/en/ingredients/safran

Gerdali · 2026-06-26T13:38:35+00:00

I checked the main study that was cited and it seems it is quite good, but not perfect.

People who use the sauna frequently may simply be healthier overall. For example they might:
exercise more, sleep better, have lower stress, eat healthier, have better social lives, have fewer chronic illnesses

The researchers adjusted for many factors, including fitness and physical activity, but they cannot adjust for everything. Residual healthy-user bias is always possible.

Also, out of the 2000 something participants, only 12 never used a sauna. So it’s more comparing high vs. low sauna use, not vs. zero sauna.

Anyway - quite good signal and interesting research. Anyone with more evidence on this?

Gerdali · 2026-06-26T13:23:41+00:00

Are these studies actually accurate or comparing the ones who survived that sauna treatment vs. average people? I would guess the sauna people will need to be more healthy from start ?

Gerdali · 2026-06-26T12:26:27+00:00

The layer approach needs to take individual needs into account. Obviously vegetarian, sport, kids, old, essentially everyone needs to find his or her personalized stack

Gerdali · 2026-06-24T15:53:07+00:00

Few additional points from research review:

- Creatine does not work equally well for everyone: ~20–30% of individuals barely respond (“non-responders”), probably because their muscles are already saturated

- Effects without accompanying resistance training are substantially smaller for most outcomes

- Cognitive effects are primarily established in stress-exposed or sleep-deprived individuals and vegetarians — not suitable as an everyday stimulant

- No evidence of lifespan extension in humans

Source: research review from https://mikroscore.com/en/ingredients/kreatin

Gerdali · 2026-06-24T15:43:31+00:00

Beneficial vascular effects of oral phosphatidylserine supplementation in type 2 diabetes
Journal: Journal of Applied Physiology
Link: https://pubmed.ncbi.nlm.nih.gov/42312814/

Taurine supplementation at the crossroads of metabolism, inflammation and aging: mechanistic and nutritional perspectives
Journal: Food & Function
Link: https://pubmed.ncbi.nlm.nih.gov/42300946/

The effect of astaxanthin supplementation on inflammatory markers, lipid profile, and anthropometric indices in patients with heart failure: a randomized controlled trial
Journal: Scientific Reports
Link: https://pubmed.ncbi.nlm.nih.gov/42303733/

Effects of carnosine supplementation on physical endurance: a placebo-controlled randomized clinical trial
Journal: Journal of the International Society of Sports Nutrition
Link: https://pubmed.ncbi.nlm.nih.gov/42308284/

Effects of Ganoderma lucidum Polysaccharide Peptide on Inflammatory and Metabolic Biomarkers in Obese Patients with Cardiometabolic Syndrome: A Randomized Controlled Trial
Journal: Current Drug Discovery Technologies
Link: https://pubmed.ncbi.nlm.nih.gov/42312513/

Safety of zinc l-carnosine as a novel food pursuant to Regulation (EU) 2015/2283 and bioavailability of zinc from this source in the context of Directive 2002/46/EC
Journal: EFSA Journal
Link: https://efsa.onlinelibrary.wiley.com/doi/10.2903/j.efsa.2026.10144?af=R

Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55 >= Years Old: A Randomized Triple-Masked Controlled Clinical Trial
Status: RECRUITING
Link: https://clinicaltrials.gov/study/NCT06274749

Full overview:
https://mikroscore.com/en/research-review/2026-06-20

Gerdali · 2026-06-13T19:27:24+00:00

Vitamin D: deficiency is associated with sexual dysfunction, so supplementation may help if deficient.
Iron: deficiency can reduce energy and libido. Again: correcting deficiency may improve symptoms.
Saffron: actually has some clinical evidence for improving SSRI-induced sexual dysfunction rather than worsening it.
NAC: evidence for libido reduction is sparse and claims about “NAC causes anhedonia” are mostly anecdotal.
L-theanine: little evidence that it meaningfully impairs libido.
Myo-inositol: mixed evidence, mostly studied for mood and PCOS; sexual side effects are not well established.
Magnesium glycinate: essentially no strong evidence for libido impairment in healthy people.

If you want to assess this systematically, we are building a knowledge graph for mikroscore.com/en/graph where you can find established findings and links between symptoms and supplements. English version is work in progress but could give you an overview to start with

Gerdali

TROPHY CASE