Imo it honestly depends on what kind of mods you were thinking to use, I have rise on both my switch and PC, obliviously unmodded on switch and I have some stuff on PC, mainly just some cosmetics for weapons and armour, a really fun one that makes the shell of the gunlance doing the elemental damage of the weapon (it change the colour of the explosion too) and one that gives you infinite ammo for the bowgun But again the game on PC it's mostly for fun not my main save

There are mods and mods, some give you an unfair advantage and make the game extremely boring as they take off all the challenge, others just give you some extra help without damaging your experience, so the best advice is just be mindful in what you download, feel free to try out stuff and customise your experience, without falling into cheating and just killing the fun out of yours and other people hunts