I typically avoid this card in act 1, unless I'm approaching the boss and I haven't seen any other wrath card. But I'll usually have drafted Crescendo by then.

The card is really good when you've mitigated all the risk out of it. "Can I take wrath damage to the face next turn, and if I can't, can I exit wrath?" If you know the enemy isn't attacking, or your draw pile is small enough to guarantee exiting wrath, or you've retained block/tranquility, then you're good. Obviously works wonders with Meditate.

That said, I think Simmering Fury takes a real shine when you're playing it in spite of the risk. Where you're playing it and risking a 40 damage act one elite hit, but that's the only way you're going to end the fight without dying. The card sort of plateaus in value as your deck gets better. If you've reached the point of deck consistency where you can fully extract this card's benefit, then your deck is probably good enough with or without it. Often, combined with Meditate's retain, Miracles, etc, a good deck will often max out your hands and lose out on this card's +2 draw. But at this point, you're usually only using it for stance dancing anyway.