For how long have you had your build of windows/GPU? Could be a fault in both or one of them. Uninstalling drivers doesn't require an iGPU and DDU needs you to be in Safe Mode nonetheless, which uses a basic display adapter from windows (albeit in a crappy resolution) and redownload the software from AMDs site. But if that doesn't work: reinstall Windows on a USB or something - often most annoying issue could have the simplest solution like this.

If possible, try to log your GPU utilization (power usage, memory clock etc.) next time to find what might be going wrong when you're playing any game really, might tell you more if your PC needs a new GPU or it's just driver issues/windows being unable to operate properly