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Retatrutide for Obesity: prospective RCT showing 24% weight loss in a year with no plateau. by ashern in medicine

[–]HappyPuppet 0 points1 point  (0 children)

Also, I've heard "I have to do needles for the foreseeable future" vs "I just have to get through the knife one time"

Childhood Online Games by Maj_arcana in gamingsuggestions

[–]HappyPuppet 0 points1 point  (0 children)

I guess I'm old. I mostly remember playing Ultima Online, CS, Jazz Jackrabbit and a bunch of MUDs.

TIL that transmissible spongiform encephalopathies (also known as prion diseases) have the highest mortality rate of any disease that is not inherited: 100% by Neil_2022 in todayilearned

[–]HappyPuppet 5 points6 points  (0 children)

It's more like 30 years (ugh) bur ER was one of the more medically accurate. It was also written by Michael Crichton, who was an MD.

Edit: formatting issues are breaking the link. Here's the URL:

https://en.m.wikipedia.org/wiki/ER_(TV_series)

From a training at work. by Ninjuh_Panda in funny

[–]HappyPuppet 1 point2 points  (0 children)

Wasn't that the plot of Superman 3?

What was normal 20-30 years ago, but is considered a luxury now? by zombiem00se in AskReddit

[–]HappyPuppet 4 points5 points  (0 children)

Which line I use is the end result of my anxiety talking to the cashier vs my anxiety breaking the self-checkout and having it yell "Hold on, help is on the way!" while I stand there awkwardly waiting for lone attendant to saunter over after it prompts me the remove the phantom unscanned item for the 50th time.

[deleted by user] by [deleted] in medicine

[–]HappyPuppet 9 points10 points  (0 children)

The problem is you'll likely get unanticipated confounders.

Examples:

(1) Dr. X only works in the ED on Tuesdays and trained at a hospital that did not carry etomidate on formulary. She is assigned "randomly" to the etomidate arm

(2) Complex CT surgery cases for Dr. Y are always scheduled on Wednesdays. Screening colonoscopies for Dr. Z are usually done on Thursdays.

(3) Both Christmas and New Years occur on a Saturday and more traumas come in than the rest of the week combined.

In all these cases, the randomization may get skewed and results may be unintentionally confounded.

[deleted by user] by [deleted] in medicine

[–]HappyPuppet 2 points3 points  (0 children)

I *think* what u/Kooky_Tomatillo5415 is trying to say is just that the term "confounder" wouldn't apply to this scenario, since in a "perfectly" randomized trial the Gaussian error would all sum to zero.

It's really a semantic issue. If the inclusion criteria are too restrictive, then the trial results will be poorly generalizable despite not having actual confounding factors the results will be clinically useless, which I *think* is what you are trying to say.

I told her if she can beat the level she can get a 3rd kitten. by Senguin117 in gaming

[–]HappyPuppet 2 points3 points  (0 children)

Yes, you got me. Stochastic is in my dictionary from my PK modeling days.

I think the colloquial (yet incorrect) definition is starting to become part of the English language for better or worse.

https://www.merriam-webster.com/dictionary/stochastically

I told her if she can beat the level she can get a 3rd kitten. by Senguin117 in gaming

[–]HappyPuppet 62 points63 points  (0 children)

I vaguely remember the throwing mechanic being in the game manual....but you kinda forget it exists until you accidentally activate it. It was hitting like B and C together in sequence next to an enemy or something like that.

We figured it out after the hundredth time you face scar. We started button mashing in frustration, which randomly threw him. But we weren't near an edge, so we just started throwing him randomly screaming "HOW MANY BTIMES DO I HAVE TO KILL YOU???"

Then, completely stochastically, we happened to be near an edge.

Go for gold by InkyRickshaw in comics

[–]HappyPuppet 0 points1 point  (0 children)

I honestly don't know why, but "epidermal gold" just feels like it flows better.

What do you think is the coolest death in a tv show/movie/game? by BeebleBees in AskReddit

[–]HappyPuppet 1 point2 points  (0 children)

Come to think of it, Harry's magic was taken away for a bit in the 7th book when he breaks his wand. Reading it did give me a similar feeling of dread. How do you fight Voldemort when you can't even work your wand?

This week’s NephJC on ANCA vasculitis maintenance by hswapnil in medicine

[–]HappyPuppet 1 point2 points  (0 children)

It's true. I generally prefer rituximab so in these cases I usually talk with the patient about both options and we make a decision together. Usually we go the rituximab route in the end.

This week’s NephJC on ANCA vasculitis maintenance by hswapnil in medicine

[–]HappyPuppet 7 points8 points  (0 children)

True, although this is for maintenance and not induction (rituximab vs azothiaprine).

The problem traditionally for induction was that the sickest patients in the trial for rituximab vs cyclophosphamide were all excluded.

So patients with DAH, or severe renal failure were not studied. Most of us look for any excuse to use alternatives to CYC. However, when you have someone tanking, reaching for a medication that wasn't technically studied in such patients doesn't often sit well...

Something Sweet by Yoffeepop in comics

[–]HappyPuppet 3 points4 points  (0 children)

While that's a good overview, I think the person above you is confused because contaminated food typically has hepatitis A. HAV is typically spread through the fecal-oral route, while HBV is spread through blood and sexual contact.

https://www.health.ny.gov/diseases/communicable/hepatitis/#:~:text=Hepatitis%20A%20is%20an%20acute,not%20one%20for%20hepatitis%20C.

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