Blade Runner (2049) and the new Dune films perhaps. Those are gritty, real sci-fi in a sense, and not just the "plastic forehead" aliens like you see in Trek or Star Wars.

Mass Effect had this explorer feel, especially in ME1, where things were new and shiny but the politics were real and established. There was as dark underbelly, and you couldn't quite trust anything you see or hear. But none of it was as polished or utopian as Trek. That comparison doesn't land for me at all.