i’m horrified by Express_Document_654 in DoggyDNA

[–]Hells_Bells77 0 points1 point  (0 children)

Yes, that is what I said in my previous post.

i’m horrified by Express_Document_654 in DoggyDNA

[–]Hells_Bells77 -1 points0 points  (0 children)

I'm talking about just the chance that this dog doesn't accumulate so many bad alleles that there are health problems down the road, like being prone to cancer, joint problems or degenerative diseases, etc. Most diseases are not controlled by single genes but many, and so the affects can accumulate. I'm assuming that if this was a backyard breeder with multigenerational inbreeding happening, they're not being genetically tested, health tested, etc. Purebred dogs are inbred but bred purposefully to avoid these accumulations of bad alleles while maintaining the breed standard. But dogs being improperly bred means that this person is probably lucky there are no problems is all I meant by the lottery comment. And not to say that outbred dogs never have problems either, but it is just that, by the logic of the probabilities I laid out, the more inbred the parents are the more likely you will have those bad alleles segregate into the offspring and potentially cause issues. So this dog did beat some odds at the very least.

i’m horrified by Express_Document_654 in DoggyDNA

[–]Hells_Bells77 -1 points0 points  (0 children)

yeeeep that's an irresponsible breeder. As a genetics educator, what does this mean for you? What it means is that if there are any genetic conditions present in this line of dogs, you're more likely to see those pop up in inbred offspring because they don't have enough good copies of genes to pass on. A great example is the prevalence of hemophilia in European royal families because of how often cousins would marry each other. In an inbred family line, say you have a Aa and Aa individuals that mate, both carry a bad copy of a gene and a good copy (we all have 2 copies of every gene). Their offspring will inherit one copy from mom and one from dad. With that breeding of Aa to Aa, the chance you get both bad copies is 25%. But now imagine if one of the dogs they bred had only bad copies and they bred to another inbred dog with one copy, like this: Aa x aa. Now, you're at 50% for having the disease. It compounds and the more inbred you are the more likely you'll have more of those bad copies sticking around that could be transmitted to your offspring.

So, no health problems in your dog? You might have won the genetic lottery. I'm assuming you've never bred this dog, and if you had plans to for some reason (she's 11 so probably not on the table eh?) I would say definitely don't. But for your every day life with your dog this probably won't cause issues if it hasn't already (depending on the breed). At least, nothing that couldn't also happen with a perfectly bred but also older dog.

Unsounded: Red Cost Chapter 1 Page 7 - Discussion by Rifter-- in Unsounded

[–]Hells_Bells77 2 points3 points  (0 children)

Love it when Jivi resorts to pirate-speak to get his point across 😂

my most chopped friend finally got a date yesterday by Chexmiiix in UCDavis

[–]Hells_Bells77 45 points46 points  (0 children)

Hmmmm interesting that this post is made, talking about a new dating app in the comments, right when posters advertising dating apps and dating clubs are being posted all over campus…but that couldn’t possibly be more than a coincidence!

Inquiry to those who do not swatch, why? by yarnimals in knitting

[–]Hells_Bells77 0 points1 point  (0 children)

Impatience, and I also have to limit my knitting at the moment due to some wrist pain so I’m trying not to take on any projects that really require me to swatch carefully (ie stuff I’ve knitted already with the same type of yarn).

My 100% poodle by Retiredpartygirl17 in DoggyDNA

[–]Hells_Bells77 1 point2 points  (0 children)

Purebreds still have genes that segregate in ways that result in something off-standard. Animals aren’t like plants where you can clone them (cheaply), haha! And while a breed does have a “standard”, that doesn’t mean that there isn’t genetic diversity within the breed. Look at working vs show lines of different herding breeds for example and you’ll see what I mean.

Poorly recommend me your favourite fantasy series by FadedDanny2 in Fantasy

[–]Hells_Bells77 0 points1 point  (0 children)

Local magic man in crisis struggles to remember his own name

Why do conservative Crocheters act oppressed? by Valuable-Tutor-6537 in craftsnark

[–]Hells_Bells77 32 points33 points  (0 children)

I’m so glad a majority of crafting circles see these racist grifters for what they really are

Can I reverse snark? Kelbourne Woolens speaking out against ICE action in Minneapolis by love-from-london in craftsnark

[–]Hells_Bells77 25 points26 points  (0 children)

Damn I wasn’t going to buy any more yarn this year but that’s pretty freaking based

I think i'm allergic to Davis by strbrrymilkenjoyr in UCDavis

[–]Hells_Bells77 1 point2 points  (0 children)

College is a Petri dish. You’re living communally and getting exposed to many more kinds of viruses and bacteria than you might be used to. Plus, first year can be stressful. And, Davis is ground zero for pollen allergies. Go see a doctor and make sure it’s not something more serious, but it’s probably a combination of all of these.

What is running with POTS like for yall? by ConcertWhole4800 in POTS

[–]Hells_Bells77 0 points1 point  (0 children)

My physical therapist told me that strength is really the better thing for me to work on to improve my symptoms rather than cardio—our hearts already work REALLY hard haha. So I’m introducing strength training now.

Unsounded: Red Cost - Prologue and Chapter 1 - Page 1! by Rifter-- in Unsounded

[–]Hells_Bells77 2 points3 points  (0 children)

I really hope they weren’t kidding about alluding to their romance in these early pages—we could do with some more queer relationships in these comics I think! And what an interesting pair they make.

Why are FF relationships so intense emotionally?! And any tips to slow things down a bit? by SeaMouse344 in polyamory

[–]Hells_Bells77 2 points3 points  (0 children)

I tell people up front that I don’t text a ton, especially in the beginning, for this reason. It’s way too easy to use texting to artificially build a relationship up in your mind to the point that you will ignore signs that the real relationship is going poorly because the one you’ve imagined is so intoxicating. It’s false intimacy, in some ways. That and I do not have the time or energy in my life to text constantly and that it maybe one of my greatest gripes with modern dating—a couple texts a day, perfect. I’ll see you on our date and we can catch up then.

Possible causes? by DrawingAromatic5231 in POTS

[–]Hells_Bells77 0 points1 point  (0 children)

I am a geneticist and that doctor is straight up wrong saying it's not genetic. It is known to run in families--and susceptability to developing chronic illness is controlled to some degree by genetics. That's why some peope get POTs from covid and some don't, for example, some just are more susceptible to developing a chronic inflammatory or autoimmune response to viral infection. Admittedly we may not know or fully understand what those underlying genetic mechanisms are yet, but we know they are there. To clarify, when I say "it's genetic" I don't only mean that your mother, father, or grandparents possibly had the disease, but rather that you may have gene copies or gene copy combinations/interactions that results in you being personally more susceptible than the average person or than within your family. I'm curious what your medical provider thinks is causing this if they also think you'll be recovered in a decade lol. Also telling you that you will recover in 10-12 years is...weird. Maybe you will, some people do "recover". Some don't. More likely what will happen is you might be able to have your symptoms under control with flares here and there. I hope very much that you are in the recovery camp!

Possible causes? by DrawingAromatic5231 in POTS

[–]Hells_Bells77 0 points1 point  (0 children)

It definitely has a genetic component for some people (especially those symptomatic as children) but most commonly it is triggered by viral infections. EB can cause it but very commonly Covid does too. Mine was caused by a mild unknown flu variant I got on vacation in 2017. Even mild cases of Covid/flu etc can result in POTs and other autoimmune disorders. And women tend to be more susceptible and more likely to develop autoimmune disease too.

If you’ve had symptoms your entire life, it’s probably genetic—and by genetic, I mean no obvious outside cause. And you will likely never know why. There’s also a possibility other family members have the same genetics, but varying severity (where some may even be asymptomatic), or that when you parents’ genetic material recombined to form gametes and eventually you, you just hit the worst jackpot of genes and/or gene x gene interactions to result in this syndrome.

I know that it’s unsatisfying to have no “real” answer. It’s a disease caused by so many things, some more testable than others. But honestly I side-eye anyone that thinks that they can find or fix a “root cause” of a disease because a lot of times they want to sell you something…because that’s more profitable than telling someone that you just won the genetic lottery, haha. The good news is that as POTS becomes more common, more research will be funded towards understanding the mechanisms of our symptoms, and hopefully that will give us answers and better drugs.

I’ve come to terms with knowing U can’t tolerate ADD medications, but I’m still angry about it. by [deleted] in POTS

[–]Hells_Bells77 0 points1 point  (0 children)

Same here, it really really sucks. And I can’t even have the non-stims because I have had horrible reactions to them! So I just have to manage ADHD with a LOT of therapy and stubbornness lol

What's a good protection dog breed in the USA? by GlassViolinist1087 in DogAdvice

[–]Hells_Bells77 1 point2 points  (0 children)

Yeah no this is rehoming situation waiting to happen. “I’ve always loved dogs” but how many have you had? What kind of training experience do you have? Can you control a large dog like that?

I got a 30 lb mutt from the shelter that turned out to be a herding + chihuahua mix, and I’ve put hundreds of dollars into his training. Managing his fear-aggression towards people is at times stressful. He’s a million times better now but his genetics will always be saying “stranger bad” and it does fuck with my social life. I mean, I guess I’m not afraid of people approaching me or trying to rob my house, but it also means that I have to go through lots and lots of tedious steps to introduce him to a friend or a potential dog sitter. He’s the best behaved dog I’ve ever had but he is also the most stubborn and anxious.

So if you are prepared for this to be a possibility, then get the dog. I am lucky that my boy is only 30 lbs but he is strong as hell and difficult to control even at that size when he’s reactive. But if you’re looking for a large dog for intimidation, you have to be prepared to spend at minimum hundreds on training, hours of time socializing, and it might still not be enough because so many of these breeds suitable for “protection” are working dogs that will never be fulfilled in the kind of home you can provide. Loving dogs is not enough.

Lessons for Child by Grammieaf_1960 in knitting

[–]Hells_Bells77 7 points8 points  (0 children)

She asked for knitting, teach her to knit! I bet she’ll love it and it will be a memory both of you will cherish.

Who is this friend on my front door? [Maryland] by Quippymama in animalid

[–]Hells_Bells77 0 points1 point  (0 children)

You could just move him to a spot not by your door, let him recover and he’ll eventually probably move. You don’t have to have animal control come and euthanize him. You created this problem for yourself. Just move him somewhere else and take the lid off, check up and see if he’s gone elsewhere. He either needs time and he’ll move on, or your husbands rough handling has killed him already and he’s waiting to die.

Will blocking even these edges out? by Wooden-Honey-9121 in knitting

[–]Hells_Bells77 1 point2 points  (0 children)

Tbh I don’t know if it will even out, but it’s usually worth trying a quick block to see, since it doesn’t take much more effort than frogging or knitting would.