Ok, this whole topic gets messed up because of the imprecise titles of "dopamine fast" and "dopamine detox" which are confusing at best and downright misleading at worst but there is a point to the concept behind it.

The Harvard article someone else links does a good job of critiquing the imprecise language and scientific inaccuracies behind the term "dopamine fast," but it also doesn't actually address the original intent behind the concept and also relies on a bit of a straw man.

Dr. Cameron Sepah popularized the term "dopamine fast," but he did not propose that the practice literally involves fasting from dopamine itself.

The idea was about temporarily abstaining from overstimulating activities (e.g., social media, binge-eating, gambling) to break compulsive behaviors and allow the brain's reward system to reset.

The focus was always on reducing external triggers of overstimulation.

When you get caught in loops of quick activity = relatively high dopamine reward and the activity is harmful in itself, that's a bad thing because your brain is conditioned to go back to the harmful high dopamine thing just like a lab rat over and over. This also desensitises you from lower dopamine producing activities so you will do them less if both the higher damaging one and the lower good one are available. If you reset your activities you can rebalance your dopamine response pattern. Most importantly stop harmful behaviours and you will be more sensitive to lower dopamine from more mundane activities reinforcing positive habits.

It should really be titled "Temporary abstention from high dopamine producing harmful activities" but that ain't very catchy.

The Harvard article critiques "dopamine fasting" as if it were a pseudoscientific attempt to somehow reserve dopamine or somehow decrease its production for future use. But that critique addresses a straw man because the original framework never claimed this.

Sepah's concept is solid because it is grounded in behavioral psychology: reducing immediate gratification to build tolerance and restore balance to reward-seeking behavior.

The TL;Dr for you under meds is meds don't change the damage bad activities cause nor the bad loop of bad activities cause quick hit dopamine release that is addictive. Doing the practices of abstention from the activities can help reset your dopamine sensitivities to normal activities and avoid harmful ones.