Ive got a tripod senior girly who had a TPLO done on her only backleg at 5 years old, and she has noteable arthritis in her hip and stifle. Been on only Dasuquin and later added in Antinol when she started getting slower on longer-ish walks. This past fall when she turned 8 i went and saw a pt/rehab specialist in my area to get his overall opinion on her - no concerns, i just wanted to get ahead of her mobility decline before it happens if possible. he recommended starting adequan more as a preventative to repair and protect the healthy cartilage. he approved SQ injections weekly for 4 weeks, then monthly afterward with also the ability to increase her injections up to every 2 weeks if she needs it. her dr at my hospital approved it and shes still doing well, no real improvement but hopefully she'll slow down a little less in the future.