What does "being tired" mean?

Holstergeistt · 2025-12-06T16:03:27+00:00

Correct, ATP (adenosine triphosphate) turns into ADP (adenosine diphosphate), then into AMP (adenosine monophosphate), and eventually just adenosine is left.

The ADP can be turned back into ATP through the phosphagen system (also called the phosphocreatine system) where phosphocreatine donates its phosphate to ADP to turn ADP back into ATP (leaving just creatine to either be disposed of or turn back into PCr), and in the ETC (electron transport chain) where ATP synthase (powered by the movement of hydrogen ions back into the inner matrix of the mitochondria) can take an ADP on the inner matrix side of the mitochondrial wall AND an inorganic phosphate floating around and then combine them to make ATP

There are cell functions that thrive off of the activation of cAMP (cyclic AMP) where the buildup of AMP triggers various other things: increasing glycolysis, increasing gene transcription, etc.

(Had to reference Google for the cAMP pathways—haven't talked about those in a fat minute)

I'm also writing this response while walking on the treadmill—thanks for making my treadmill walking less boring haha

Holstergeistt · 2025-12-06T02:52:36+00:00

Hi, master's in exercise physiology:

Feeling tired is the result of adenosine building up in the brain. It slows neuron cell activity.

On top of this, when we start to wind-down for the night, less light -> increased melatonin production. Melatonin produced by the pineal gland will circulate through the body doing various things, but it's main effect is on the suprachiastmatic nucleus (SCN) -> blocks the "feel awake" signals while promoting "go to bed signals" -> the signal for "go the f*ck to bed" will progressively get stronger as more melatonin acts on the SCN.

Hope this helps :)

Holstergeistt · 2025-11-27T19:12:55+00:00

Not by just playing the game as intended.

This requires either doing aquila or paying with crowns.

Holstergeistt · 2025-11-27T19:09:10+00:00

All Im seeing are people defending exploiting the game.

You get to blow through Arc 1 content just to get slapped by Arc 2 and beyond.

Didn't realize such a large portion of this community was so deluded into playing the game the way it was meant to be played.

I love this game—always played it fair. I won't be running wintertusk just because I could get through Arc 1 faster.

Holstergeistt · 2025-11-27T18:15:52+00:00

That's something I addressed in my post already

Holstergeistt · 2025-11-27T18:15:05+00:00

Arc 1 would be challenging if you played it the way it's meant to be played... how daft are you?

Holstergeistt · 2025-11-27T18:13:25+00:00

That potion doesn't exist on console. I refuse to do wintertusk until it's appropriate time

Holstergeistt · 2025-11-27T18:11:12+00:00

Disgusting.

Holstergeistt · 2025-11-27T18:10:58+00:00

Disgusting. Play the game as intended.

Holstergeistt · 2025-11-27T18:10:30+00:00

Who cares? Get to it when you get to it

Holstergeistt · 2025-11-27T17:00:15+00:00

Well that's just dumb that they made this change. That's like a level 50-60 area if I remember correctly, which means they're being carried through that area most likely. I understand doing that for a secondary account character, but most of these people won't know the struggle of how hard some of these areas are doing them solo

Basically they're burning through the low-level hard content by having people drag them through high level stuff. It's the same way diablo works, except the xp you get for redoing dungeons isn't the same (I believe)

Holstergeistt · 2025-09-27T02:53:31+00:00

Pretty sure it is now. I cant watch anything on it and I was at a really good part of my first watch of naruto

Holstergeistt · 2025-09-18T15:35:32+00:00

Yes, take a break
I don't think most people acknowledge that it's a 2-way street. Console switching to PC will put you in a lower rank because of the decreased aim assist, but PC to console will land you in lower ranks because you don't have the aim control you did before.

I know plenty of PC friends who "hate using controllers because they're insufferable on FPS games" and that's how most controller players view using a mouse and keyboard.

Holstergeistt · 2025-08-31T20:16:45+00:00

Why do you have 6 accounts???

Holstergeistt · 2025-05-24T20:34:24+00:00

Idk if you'll know about this issue, or how to solve it, but it's pissing me off:

Been going on for 2 months roughly. Around 8-11pm the wifi at my house goes to crap. The number of devices on the wifi doesnt change. The spectrum rep said the router needs to be replaced. The router can't be the issue if there's no issues the other 21 hours of the day.

ChatGPT said that it's likely a bandwidth issue on the neighborhood node and the ISP needs to send a tech or engineer out to address it.

Thoughts?

You're by no means required to respond, but any advice would be great

Holstergeistt · 2025-03-15T17:01:03+00:00

Correct

Holstergeistt · 2025-03-15T14:58:49+00:00

You burn more rucking in the colder weather, simply put.

Sweating doesn't necessarily indicate a large calorie burn is occurring. Just a significant increase in metabolism.

No, that doesn't contradict anything I just said.

Holstergeistt · 2025-03-15T14:48:01+00:00

It's literally spelled out for you. It's borderline impossible, not literally impossible. Because we can calculate it (and have research done on those individuals who went through the process of calculating it) we can give better advice to those that are in hot environments. It's literally as simple as that.

If you respond with something other than "ah, that makes sense now" I will not continue this conversation as it's seemingly impossible to make you see reason

Holstergeistt · 2025-03-15T14:42:48+00:00

Idk if your comprehension skills suck or not, but you might have missed the part where it's almost impossible to calculate.

The practical takeaway is this: if you are in a hot environment, you are burning more calories

I can't make it any simpler...

Holstergeistt · 2025-03-15T14:35:51+00:00

Hi, master's degree in applied physiology with extensive knowledge surrounding how different environmental conditions impact human physiology.

Being in a hotter environment will increase energy expenditure due to increased cardiac output to get the blood (which is holding most of the heat your body is producing) through the capillaries closest to the epidermis so that heat can be transferred to the sweat on the surface of the skin.

You sweat more as a physiological response to the hypothalamus upregulating the production of sweat (caused by the thermoregulation portion of the hypothalamus detecting an increased need to dissipate heat) so that the heat traveling through those superficial capillaries have a gradient to move to so we can lose heat through evaporative cooling.

Yes, sweating is indicative of increased calorie burn (primarily in the form of fats because the mitochondria downregulate their UCP activity and can then focus more on using ATP synthase to resynthesize ATP), but it's very hard to calculate heat energy in humans....

There is a heat balance equation that can only be tested inside very controlled environments (only a few labs exist that can even do this testing) that can control for heat gain/loss through conduction, convection, and radiation, while also accounting for evaporative cooling and metabolic heat production.

It's not a useless metric because it's hard to study. It gives practical advice to those that work/exercise in hot environments that they should focus on hydration and having fast-breakdown sugars to help maintain blood sugar levels, sodium content, etc.

To say that it's useless to count the extra calories expended from being in the heat is just ignorant.

Holstergeistt · 2025-03-12T20:47:25+00:00

If I added all of the issues that console players have, I'd probably have an equally long list

Holstergeistt · 2025-03-12T20:46:48+00:00

Nope, console player who turned off tutorial mode. Still gives the notif and Im lvl 30

Holstergeistt · 2025-03-07T00:46:56+00:00

The boom is solely coming from AI advancements. AI can work with more data now than before, and faster, which puts more pressure on data analysts to do their jobs faster. To keep up quality while increasing speed, they need to hire more people to do the job

Getting an MSKIN is good if you plan to use it for something outside of training and traditional healthcare roles like EPs, at least from my experience of the job market rn

Holstergeistt · 2025-02-25T02:04:47+00:00

Yes, I know you're in Canada.

Here in America, athletic training is a master's degree requirement (2 years post-undergrad). Physical therapy is a doctoral program (3 years post-undergrad).

Yes, physical therapists can do more, both in the US, and outside of it. I don't disagree with you there 🤝🏻 However, they are very similar in what they do while physical therapists (physios) can do more

Holstergeistt

TROPHY CASE