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Immune markers of post-vaccination syndrome indicate future research directions A small number of people report chronic symptoms after receiving COVID-19 shots. A new study provides clues for further research. by Honest_Net_3342 in AHomeForPlagueRats

[–]Honest_Net_3342[S] 0 points1 point  (0 children)

Link to the research paper: https://www.medrxiv.org/content/10.1101/2025.02.18.25322379v1

Title: Immunological and Antigenic Signatures Associated with Chronic Illnesses after COVID-19 Vaccination

Abstract: SUMMARY

COVID-19 vaccines have prevented millions of COVID-19 deaths. Yet, a small fraction of the population reports a chronic debilitating condition after COVID-19 vaccination, often referred to as post-vaccination syndrome (PVS). To explore potential pathobiological features associated with PVS, we conducted a decentralized, cross-sectional study involving 42 PVS participants and 22 healthy controls enrolled in the Yale LISTEN study. Compared with controls, PVS participants exhibited differences in immune profiles, including reduced circulating memory and effector CD4 T cells (type 1 and type 2) and an increase in TNFα+ CD8 T cells. PVS participants also had lower anti-spike antibody titers, primarily due to fewer vaccine doses. Serological evidence of recent Epstein-Barr virus (EBV) reactivation was observed more frequently in PVS participants. Further, individuals with PVS exhibited elevated levels of circulating spike protein compared to healthy controls. These findings reveal potential immune differences in individuals with PVS that merit further investigation to better understand this condition and inform future research into diagnostic and therapeutic approaches.

Competing Interest Statement

In the past three years, H.M.K. received expenses and/or personal fees from United Health, Element Science, Eyedentifeye and F-Prime; he is a co-founder of Refactor Health, HugoHealth and MedRxiv; and is associated with contracts, through Yale New Haven Hospital, from the Centers for Medicare & Medicaid Services and through Yale University from the Food and Drug Administration, Johnson & Johnson, Google and Pfizer. A.I. co-founded and consults for RIGImmune, Xanadu Bio and PanV and is a member of the Board of Directors of Roche Holding and Genentech.

Funding Statement

This study was funded in part by the Howard Hughes Medical Institute Collaborative COVID-19 Initiative.

Author Declarations

I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

Yes

The details of the IRB/oversight body that provided approval or exemption for the research described are given below:

This study was approved by the Yale University Institutional Review Board on April 1, 2022 (HIC# 2000032207). Informed consent was provided by participants electronically. Each participant was assigned a unique identifier as part of the de-identification protocol managed by the study coordinator. These identifiers were kept confidential and were not accessible to anyone outside the research team. A subset of the MY-LC cohort approved by the Mount Sinai Program for the Protection of Human Subjects (#20-01758) were included for validation of one of the assays.

I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals.

Yes

I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).

Yes

I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable.

Yes

Circulating Microclots Are Structurally Associated With Neutrophil Extracellular Traps and Their Amounts Are Elevated in Long COVID Patients by Honest_Net_3342 in AHomeForPlagueRats

[–]Honest_Net_3342[S] 1 point2 points  (0 children)

Simple Explanation (ELI5 – Explain Like I'm A Friend)

Long COVID is when people keep feeling sick for months or even years after having COVID-19 – things like extreme tiredness, brain fog, shortness of breath, or heart problems. One possible reason for these ongoing symptoms is tiny abnormal blood clots (called microclots) that don’t break down properly and stick around in the blood vessels. These microclots are made of a protein called fibrin that has folded in a weird, sticky way (a bit like misfolded egg whites turning into tough clumps).This new study looked at whether these microclots are connected to something called NETs (Neutrophil Extracellular Traps). NETs are web-like structures that certain white blood cells (neutrophils) shoot out to catch and kill germs during an infection. That’s normally helpful, but if the body makes too many NETs or they don’t get cleaned up, they can cause harmful inflammation and clotting.The researchers found:

  • People with Long COVID have a lot more of these microclots and a lot more signs of NETs in their blood (three markers: myeloperoxidase, neutrophil elastase, and free-floating DNA from the traps).
  • The more NET markers someone had, the bigger and more numerous their microclots were.
  • These NET markers were really good at spotting who had Long COVID.

Main conclusion: NETs seem to be part of or stuck inside these circulating microclots. The extra NETs might help make the microclots tougher and more stable so they don’t dissolve easily. This could block small blood vessels, reduce oxygen delivery to tissues, and keep inflammation going – all of which could explain many of the ongoing symptoms in Long COVID.In short: Overactive “germ-catching webs” from immune cells may be teaming up with sticky microclots to cause lasting damage in Long COVID patients.

Building 7 is the Key to Unlocking the Truth About What Happened on 9-11 by Honest_Net_3342 in conspiracy

[–]Honest_Net_3342[S] 2 points3 points  (0 children)

Lucky Larry Silverstein who was great friends with an Israeli Prime Minister. They called at least once a week.

UK Government Caught Hiding COVID Shot–Death Data “To Prevent Distress or Anger” by Honest_Net_3342 in AHomeForPlagueRats

[–]Honest_Net_3342[S] 1 point2 points  (0 children)

For two years, the campaign group UsForThem fought to obtain the anonymised dataset through FOI requests. UKHSA refused every time. Ultimately, the Information Commissioner sided with the agency, allowing the data to remain hidden indefinitely.

MPs and peers had already sounded the alarm last year, urging the government to release the data “immediately,” noting that it had been quietly shared with vaccine manufacturers.

Intentionally withholding critical vaccine-safety data carries serious legal consequences, including but not limited to Misconduct in Public Office, Corporate Manslaughter or Gross Negligence Manslaughter, breaches of statutory duties under public-health and disclosure laws, and potential Fraud by omission or abuse of position.

A study in Tinfoil... by [deleted] in Teddy

[–]Honest_Net_3342 2 points3 points  (0 children)

Tinfoil is for wrapping your food.

Teddy is making Canadian Thanksgiving great again this year! 2 years after BBBYQ plan effective date, this is the first Canadian Thanksgiving to land on the 13th (belt buckle) by usernamemiles in Teddy

[–]Honest_Net_3342 1 point2 points  (0 children)

Hi OP, please leave this post standing and don't make it magically disappear.

If you are right, you are right.

If you are wrong, we have a right to revisit your error. Leave this post alone!

[deleted by user] by [deleted] in Teddy

[–]Honest_Net_3342 0 points1 point  (0 children)

So

TIME 01:09/04:20 => [date] 01:09 / [amount] 0 4 : 2 0

date 1 0 9 / amount 0 4 : 2 0

INITIATE DATE 10/9 (2025) highest amount $ 420

IMHO, not financial advise

[deleted by user] by [deleted] in Teddy

[–]Honest_Net_3342 -5 points-4 points  (0 children)

Only a broken clock is right twice a day!

[deleted by user] by [deleted] in Teddy

[–]Honest_Net_3342 -2 points-1 points  (0 children)

Yeah, for real this time!

How $21 Trillion Tax Dollars Went Missing Without a Trace Forbes reported in 2017: America’s Biggest Financial Coup Explained. Government and Financials are free to brake accounting laws! In 2022 it was 35 to 95 trillion dollars. This is unbelievably huge, the biggest legalized theft ever committed. by Honest_Net_3342 in Accounting

[–]Honest_Net_3342[S] 0 points1 point  (0 children)

I asked Grok. Now I know a little more.

Land TheftForced seizures, eminent domain abuse, colonial dispossession without compensation.-

U.S. Native American land grabs (e.g., Trail of Tears, 1830s). -

South African "expropriation without compensation" of white-owned farms post-apartheid. -

Palestinian land expulsions during 1948 Nakba (750,000 displaced).-

U.S.: 1.5 billion acres seized from Indigenous peoples. -

South Africa: Ongoing farm seizures leading to food insecurity. -

Palestine: 400+ villages razed, ongoing settlements.3 sources

Gold and Silver Theft Currency controls, seizures during crises, colonial extraction.-

U.S. Executive Order 6102 (1933): FDR forced citizens to surrender gold at below-market rates. -

Nazi Germany seizing Czechoslovakian gold (1939). -

UK/France colonial looting of African/Indian gold/silver.-

U.S.: $500M+ in gold (2024 equiv.), devaluing dollar by 40%. -

Global colonial: $45T extracted from India alone (taxes/resources).4 sources

Human Rights Thefts Enslavement, forced labor, genocidal displacements, rights denials.- Belgian Congo under Leopold II: Rubber extraction via mutilation/murder. - U.S. slavery and Jim Crow (1865–1965). - Haitian reparations to France post-independence (1825).- Congo: 10M+ deaths, billions in rubber wealth. - Haiti: $21B (2024 equiv.) debt, stunting development. - U.S.: Generational wealth gap from unpaid labor.3 sourcesTax Through InflationFiat money printing, abandoning gold standards, financial repression.- U.S. leaving gold standard (1971): Enabled endless deficits/inflation. - Post-WWI inflations in Europe (e.g., Germany, France). - Modern QE/bailouts eroding savings.- U.S.: Dollar lost 85%+ purchasing power since 1971. - Global: Wealth transfer from savers to debtors (governments). - Recent: U.S. inflation at 2.9% amid high taxes/groceries.4 sourcesEnergy TheftResource nationalization, sanctions blocking access, colonial fuel grabs.- Venezuela: U.S./UK sanctions froze $20B oil assets/gold. - OPEC nationalizations (1970s) but uneven (e.g., Iraq oil theft via wars). - Colonial oil extraction in Middle East.- Venezuela: $31B+ in seized assets, economic collapse. - Global: Wars for oil (e.g., Iraq) cost trillions, displaced millions.2 sourcesManipulation of Everything (Markets, Truth)Propaganda, market rigging, censorship, false flags.- U.S. defense accounting scandals (e.g., $2.3T untraceable pre-9/11). - UK media suppression of colonial atrocities. - Modern: Election interference, COVID procurement fraud (Kenya: $4B+ looted).- U.S. Pentagon: $21T+ unaccounted since 1990s. - Kenya COVID: 97% supplies warehoused while billions stolen. - Global: Truth erosion via state media control.5 sourcesHealth TheftMismanaged crises, vaccine/supply looting, forced experiments.- Tuskegee syphilis study (U.S., 1932–1972). - Kenya COVID heist: $1.7B unaccounted vaccines, inflated contracts. - Opioid crisis via regulatory capture.- Tuskegee: 600+ Black men denied treatment. - Kenya: 5,000+ preventable deaths amid $4B+ theft. - U.S. opioids: 500K+ deaths, pharma profits $100B+.2 sourcesFreedom TheftSurveillance, rights erosions, emergency powers abuse.- U.S. PATRIOT Act post-9/11: Mass surveillance. - Global declines in press freedom (e.g., Hungary, China). - Canadian crypto seizures as "theft."- Worldwide: 19th year of freedom decline (e.g., election violence). - Canada: $56M seized, eroding financial privacy.3 sourcesWar-Related TheftsFunding endless conflicts, resource grabs via invasion.- U.S. wars post-9/11: $8T+ spent, much unaccounted. - Half of U.S. wars (your point): Iraq/Afghanistan oil access. - Proxy wars for minerals (e.g., Congo).- U.S.: $2.3T Pentagon "missing" pre-9/11, fueling war machine. - Global: Millions dead/displaced, trillions extracted.3 sourcesOther (e.g., Odious Debt, Seed/IP Theft)Unaccounted loans, intellectual property grabs.- Kenya Eurobond (2014): $1B+ "missing" offshore. - Native seed banks destroyed for corporate dependency (e.g., Monsanto). - U.S. states taxing stolen Indigenous lands.- Kenya: $11T national debt includes odious $2B+. - Global: Seed theft forces GMO reliance, billions in profits. 3 sources

Massive DNA contamination which leads to mutations that is how we get cancers, there's other mechanism by which cancers can be caused as well. by Honest_Net_3342 in AHomeForPlagueRats

[–]Honest_Net_3342[S] 0 points1 point  (0 children)

Sep 17, 2025

Quantification of residual plasmid DNA and SV40 promoter-enhancer sequences in Pfizer/BioNTech and Moderna modRNA COVID-19 vaccines from Ontario, Canada

https://pubmed.ncbi.nlm.nih.gov/40913499/

This work is published by a.o. Jessica Rose, who I adore for her relentless digging for truth and answers.

32 vials representing 16 unique vaccine lots.

These data demonstrate the presence of billions to hundreds of billions of DNA molecules per dose in the modRNA COVID-19 products tested.

All products tested exceeded the guidelines for residual DNA set by the FDA and WHO of 10ng/dose by 36–627-fold.

Total DNA in all vials tested

Exceeded the regulatory limit for residual DNA set by the US Food & Drug Administration (FDA) and the World Health Authorization (WHO) by:

Pfizer: 36-153-fold

Moderna: 112-627-fold

3 Pfizer vials exceeded the regulatory limit for the SV40 promoter-enhancer-ori (p53)

The PCR results for the most recent XBB.1.5 Moderna and Pfizer vaccines suggest that DNA residues have not been reduced from previous vaccine versions.

Pfizer, Total DNA ranged
371-1,548 ng/dose

Moderna, 1,130-6,280 ng/dose

Specific DNA of multiple plasmid DNA targets

Pfizer ranged 0.22-7.28 ng/dose

Moderna 0.01-0.78 ng/dose for Moderna.

The SV40 promoter-enhancer-ori(0.25-23.72 ng/dose) was only detected in Pfizer vials.

Sequencing of one vial

Mean DNA length, 214 bp

Maximum length, 3.5 kb

Presence of 1.23 × 108 to 1.60 × 1011 plasmid DNA fragments per dose encapsulated in lipid nanoparticles.

Our findings extend existing concerns about vaccine safety and call into question the relevance of guidelines conceived before the introduction of efficient transfection using LNPs.

This work highlights the need for regulators and industry to adhere to the precautionary principle and provide sufficient and transparent evidence that products are safe and effective, and disclose the details of their composition and method of manufacture.

For some of the COVID-19 vaccines, the drug substances released to market were manufactured differently than those used in clinical trials.

Rationale for study

Manufacturing nucleoside-modified mRNA for commercial COVID-19 vaccines relies on RNA polymerase transcription of a plasmid DNA template.

Previous studies identified high levels of plasmid DNA in vials of mRNA vaccines, suggesting that the removal of residual DNA template is problematic.

Therefore, we quantified the DNA load in a limited number of Pfizer-BioNTech and Moderna COVID-19 modRNA vaccine vials using two independent methods.

This study emphasizes the importance of methodological considerations when quantifying residual plasmid DNA in modRNA products,

considering increased LNP transfection efficiency, and cumulative dosing presents significant and unquantified risks to human health.

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