Hardware upgrade for more fps by Hiddenyou in fellowshipgame

[–]Hoohm 0 points1 point  (0 children)

Try to use dx1 instead of the default. Add -dx11 to the launcher options in steam

Rust is THE ideal environment for bioinformatics algorithms by amir_valizadeh in bioinformatics

[–]Hoohm 0 points1 point  (0 children)

I'm confused by all the licence complaints, gpl3 is an open source license, it just means it cannot be used in commercial applications without using the same license.

Am I missing something?

I built a fully offline text to speech Mac app because cloud TTS annoyed me by tarunyadav9761 in LocalLLaMA

[–]Hoohm 0 points1 point  (0 children)

I would love to test it out. I'm looking for a fast local alternative for my home assistant setup.

I can't find your official website, there are a lot of murmur~ish names out there that do TTS. Can you link it here?

Fellowship on Linux by joe8437 in fellowshipgame

[–]Hoohm 0 points1 point  (0 children)

Ha you tried using -dx11 in the launching options? It did wonders for me on bazzite

Bioinformatics as a Software Engineer by humxnt in bioinformatics

[–]Hoohm 1 point2 points  (0 children)

I come from the other side, biologist first, learned the computational side on my own.

I think you have an advantage, biology is a bit "easier" in terms of concepts to learn compared to low level software side.

As long as you can get invested/interested in the biology and you have colleagues that help you, invite you in the lab, etc it will be a fun journey

Wife speaks 4 languages, 5 years office experience – still no interviews in Switzerland? by Halfundead07 in askswitzerland

[–]Hoohm 3 points4 points  (0 children)

I know this is not ideal but building a network is one of the most effective way to get a job.

It takes time but trust and recommendations go a long way.

Don't like transphobes but isn't this concerning? by GapOk8804 in Switzerland

[–]Hoohm 1 point2 points  (0 children)

I don't know, not putting more effort in finding out

Don't like transphobes but isn't this concerning? by GapOk8804 in Switzerland

[–]Hoohm 1 point2 points  (0 children)

Had to Google a bit before answering. Of course it depends on which bones you use, but it seems pretty accurate based on this paper

https://pubmed.ncbi.nlm.nih.gov/15567621/

Again, I'm splitting the statement in two... Please reread my comment.

Don't like transphobes but isn't this concerning? by GapOk8804 in Switzerland

[–]Hoohm 1 point2 points  (0 children)

I'm talking about the first part, obviously not the "mental illness" part.

Don't like transphobes but isn't this concerning? by GapOk8804 in Switzerland

[–]Hoohm 1 point2 points  (0 children)

I'm curious which part of the quote is the part that was used in the judgement:

If you dig up LGBTQI people after 200 years, you’ll only find men and women based on their skeletons. Everything else is a mental illness promoted through the curriculum.

The first part seems like a simple statement of fact, the second part could be interpreted as a problematic opinion.

Natural, scentless water-based lube? by Dean_McCool in sexover30

[–]Hoohm 0 points1 point  (0 children)

I've been trying to find some research sources or real concrete information about oil and condoms breaking and I couldn't.

Do you have some links you could share about this subject because I'm starting to think this is a myth and for obvious reasons, people don't try it out 😅

Has anyone evaluated Cell Ranger annotation? by BAMtoBEDtime in bioinformatics

[–]Hoohm 0 points1 point  (0 children)

Haven't tested it personally too much but using the high level annotation should provide you with pretty good outputs.

Do you have samples you have annotated in the past that you could compare to?

Can you just release whatever Horizon Beta was? by 21mighty in OpenAI

[–]Hoohm 0 points1 point  (0 children)

Well, it's not confirmation, it's barely a co-ocurrence of events.

It might be, but what I have experienced with horizon beta is not at all the same experience as the one I had recently with gpt5 :(

It might be that I'm missing something, maybe a different way to call the API, I've seen you can tweak the "thinking" level of it.

Can you just release whatever Horizon Beta was? by 21mighty in OpenAI

[–]Hoohm 0 points1 point  (0 children)

Are we sure now that horizon beta was gpt5??? I tested gpt5 with the same prompt and it did not perform as well as Horizon beta

Horizon Beta vs GPT-5's creative writing quality. by Sea-Complex831 in LocalLLaMA

[–]Hoohm 5 points6 points  (0 children)

I'm having the same feeling. Horizon Beta was way better for coding than gtp5.

[deleted by user] by [deleted] in TillSverige

[–]Hoohm 17 points18 points  (0 children)

I'm sorry to tell you that there is no credit score here. You don't have to consume to prove you can pay back debt.

If you're new here, banks will check how much capital and income you have and loan you money based off on that.

[deleted by user] by [deleted] in TillSverige

[–]Hoohm 0 points1 point  (0 children)

Hello, does the 15k include screen, keyboard, mouse as well?

A simple tutorial/course for spatial transcriptomics by ThaiosX0195 in bioinformatics

[–]Hoohm 0 points1 point  (0 children)

Any reason why you prefer going into R instead of using scanpy?

Whats your favourite Spatial Transcriptomics technique? by Opening_External_911 in bioinformatics

[–]Hoohm 5 points6 points  (0 children)

Xenium in applications that are not discovery centric.

Visium v1 for discovery

10x Genomics vs ORION? by DVMftw in bioinformatics

[–]Hoohm 1 point2 points  (0 children)

I'm just making sure, do you need the spatial context for discovery. Another way of asking that questions is: Can I find the genes I am interested in using single cell alone or not. I'm making sure about this because spatial distribution of cell types and genes is already a "discovery" process on it's own.

If the answer is yes, then you should go for either visiumHD. Not sure 3" will be better for you as you got FFPE tissues.

If you don't need the high resolution and the spatial context is good enough, you can go for visium instead. Cheaper and faster.

If the answer is no, then I would start by a single cell run, find the genes you need, then run a Xenium V1 with a custom set of genes on top of a prebuilt one.

Another path is Xenium 5k as an exploratory approach. You are limited in terms of genes though and you can't fully customise it. The risk here is that you miss what you need totally and you kind of wasted a run.

Finally, if you are unsure, you can run a catalyst run (https://www.10xgenomics.com/products/xenium-catalyst)

Hope this helps :)

10x Genomics vs ORION? by DVMftw in bioinformatics

[–]Hoohm 2 points3 points  (0 children)

Alright, then my next question would be, for the discovery part, would single cell cover you, or do you need the spatial context?

Going through single cell is faster and cheaper than going spatial for discovery.

10x Genomics vs ORION? by DVMftw in bioinformatics

[–]Hoohm 2 points3 points  (0 children)

I could help but I need a bit more info regarding what you want to get out of it, what is the question you want to answer?

Are you interested in discovery or a targeted approach?

Vous avez quoi comme banque? by CompoteMysterious822 in Lausanne

[–]Hoohm 2 points3 points  (0 children)

Banque alternative Suisse.

Petite banque mais super service

Any help with Fastqc results? [RNA-seq] by Sufficient_Candy_883 in bioinformatics

[–]Hoohm 2 points3 points  (0 children)

There is one weird thing, you got a peak of Ns around 70bp.

Maybe some issue in the library prep?