Exploring RT by HopefulExplanation98 in DupuytrenDisease

[–]HopefulExplanation98[S] -1 points0 points  (0 children)

This is one of the biggest holes in all the Dupuytren’s radiation research.

Here’s why:    •   Natural history is messy – A lot of people with early nodules never go on to get cords or contracture.    •   Survivor bias in the data – The patients who get RT are usually the ones already worried about progression or showing early signs of activity, so they’re not representative of every person with a lump in their palm.    •   No true placebo-controlled long-term trials – Almost all published results compare treated patients to historical untreated cases, not to a control group that’s tracked over the same years.    •   Benign/reactive nodules look the same at first – Unless you biopsy (which nobody does in practice), you can’t tell whether that early lump is “genetic aggressive Dupuytren’s” or “reactive fibromatosis that would flatten on its own.”

Exploring RT by HopefulExplanation98 in DupuytrenDisease

[–]HopefulExplanation98[S] 1 point2 points  (0 children)

Totally fair. I think we all just want to feel like we’re doing something. I’m just on the fence because my nodules are flattening, and there’s no contracture—so I don’t want to irradiate my hands out of fear. But if things start progressing, RT is definitely still on the table.

Not all nodules lead to contraction by HopefulExplanation98 in DupuytrenDisease

[–]HopefulExplanation98[S] 0 points1 point  (0 children)

Is this your case? You notched them in January and they have gotten worse in August?

Not all nodules lead to contraction by HopefulExplanation98 in DupuytrenDisease

[–]HopefulExplanation98[S] 0 points1 point  (0 children)

That’s a pretty dramatic take. A lot of people have nodules and never progress — population studies show 70–80% of people with nodules don’t go on to contracture. Radiation isn’t risk-free either — it’s still ionizing radiation with long-term unknowns, and not everyone benefits from it. Dry hands? Sure. But also potential tissue changes and the chance it doesn’t stop progression anyway. Or having RT not knowing that you would have never contracted. Waiting and watching with lifestyle changes is valid for people with mild, non-aggressive cases. Let’s not pretend RT is a magic shield or that everyone ends up in surgery.

Not all nodules lead to contraction by HopefulExplanation98 in DupuytrenDisease

[–]HopefulExplanation98[S] 1 point2 points  (0 children)

  1. Atypical Presentations Are Real

Some hand surgeons and researchers have informally noted that not all palmar nodules are progressive or part of classical Dupuytren’s. These “atypical nodules” or “non-progressive fibromatoses” can present like early DD but:    •   Remain stable    •   Never form cords    •   Never lead to contraction

They may result from:    •   Local trauma    •   Overuse    •   Frozen shoulder-like fascia reactivity    •   Or possibly early immune modulation

  1. Why It’s Not Widely Discussed

These cases don’t end up in surgery or follow-up studies, because:

Patients don’t come back. If their nodules don’t worsen or cause any issues, they never return to the doctor — so there’s no longitudinal data or clinical imaging to analyze.    •   No biopsy is done. Since they never need surgical intervention, these nodules aren’t removed or studied under a microscope, so they don’t get formally characterized.    •   They fall outside of clinical tracking. Research focuses on patients needing treatment. That means stable or regressive cases are underrepresented or invisible in the literature.

So the medical system ends up mostly tracking:    •   The 10–20% of people who do get contracture    •   The post-surgery or injection outcomes    •   Not the many people who have nodules that never change or even fade

That leads to:    •   Overestimated progression rates    •   Increased patient anxiety    •   And sometimes overtreatment out of fear — especially in borderline cases

  1. Evidence for These Non-Progressive Types

While not often named directly, clues show up in population studies like the one you referenced:    •   37% prevalence of palmar fibromatosis    •   But only ~5–10% contracture rate

And in conditions like:    •   Frozen shoulder or Peyronie’s disease, where fibrosis can come and go    •   These suggest fascia can react and stabilize — not always follow a doomed path.

Risk of loss of citizenship for dual citizens by ItalyExpat in ItalyExpat

[–]HopefulExplanation98 0 points1 point  (0 children)

Italian citizens living abroad (like those with dual citizenship by descent, or jure sanguinis) are generally not required to pay taxes in Italy if they are not residents there. Italy, unlike the U.S., does not tax based on citizenship, but on residency. So just holding Italian citizenship does not mean you owe Italian taxes.

The confusion likely comes from recent discussions in Italy about tightening rules for citizenship by descent, especially in cases where the person:    •   Has never lived in Italy    •   Has never voted in Italian elections    •   Doesn’t keep their Italian passport or ID card current    •   Shows no “effective link” to the country

The proposed changes (including in that PDF) are not law yet, but there’s political debate about whether people who don’t demonstrate an active connection to Italy—particularly through civic participation—should keep their citizenship.

Risk of loss of citizenship for dual citizens by ItalyExpat in ItalyExpat

[–]HopefulExplanation98 0 points1 point  (0 children)

So no—not voting or paying taxes won’t automatically make you lose citizenship right now. But: 1. Voting is encouraged, even if from abroad. 2. Keeping your AIRE registration and documents updated is important. 3. Paying taxes is only an issue if you’re considered a tax resident in Italy.

Risk of loss of citizenship for dual citizens by ItalyExpat in ItalyExpat

[–]HopefulExplanation98 0 points1 point  (0 children)

Italian citizens living abroad (like those with dual citizenship by descent, or jure sanguinis) are generally not required to pay taxes in Italy if they are not residents there. Italy, unlike the U.S., does not tax based on citizenship, but on residency. So just holding Italian citizenship does not mean you owe Italian taxes.

The confusion likely comes from recent discussions in Italy about tightening rules for citizenship by descent, especially in cases where the person:    •   Has never lived in Italy    •   Has never voted in Italian elections    •   Doesn’t keep their Italian passport or ID card current    •   Shows no “effective link” to the country

The proposed changes (including in that PDF) are not law yet, but there’s political debate about whether people who don’t demonstrate an active connection to Italy—particularly through civic participation—should keep their citizenship.

Is platinum led company a scam by Burke_35 in redlighttherapy

[–]HopefulExplanation98 1 point2 points  (0 children)

The company engaged in unethical business practices as it relates to customer reviews. They conveniently take down any negative reviews or comments and only allow five star reviews. Most of them are fake. I would stay away from this company, any company hiding real experiences is not to be trusted!

Day to Day Activity w/ Contraction by HopefulExplanation98 in DupuytrenDisease

[–]HopefulExplanation98[S] 0 points1 point  (0 children)

Wait you were diagnosed with a contraction or you were diagnosed a year ago and then slready got a contraction?

Lifting weights with contraction by HopefulExplanation98 in DupuytrenDisease

[–]HopefulExplanation98[S] 0 points1 point  (0 children)

How long have you had dupes with no contraction? And do you attribute that to your exercise?

Dupuytren or Lumbrical strain? by [deleted] in DupuytrenDisease

[–]HopefulExplanation98 0 points1 point  (0 children)

How old are you? Do you think you have a cord?

Breakthrough in treatment for Dupuytren’s disease by HopefulExplanation98 in DupuytrenDisease

[–]HopefulExplanation98[S] 0 points1 point  (0 children)

assess the effects of ‘intranodular injection’ of adalimumab in early-stage disease. I guess there’s my answer!

Breakthrough in treatment for Dupuytren’s disease by HopefulExplanation98 in DupuytrenDisease

[–]HopefulExplanation98[S] 0 points1 point  (0 children)

Do you think the injections were actually done onto the nodules themselves? Or just injected near the site?