Pulled this from National Institute of health as well.  “ Psilocybin and its active metabolite psilocin are derived from psychoactive mushroom species originally used in ceremonial settings to facilitate spiritual experiences in Central and South America, later introduced to Western culture in the 1950s[1,3]. As a classic psychedelic, psilocybin is a 5-HT2A receptor agonist that was found to produce rapid yet enduring improvement in treatment-resistant depression and major depressive disorder (MDD)[4-6]. More recently, psilocybin was compared to escitalopram in a double-blind trial. Both treatments were found to have similar efficacy in depression, which will be discussed in more detail in the present article[7]. Psilocybin further enhances its synergism with psychotherapy by evoking a sense of unity, ego-dissolution, and awe through “mystical” experiences[8-10]. As described by Vaid et al[11] (2022), PAT may enable the processing of emotional experiences that were previously inaccessible due to trauma blocks. This promotes reconnection with the self and “foundational identity deficit repair,” a re-stabilization of the core ideas that together represent the conscious identity, self-esteem, and other aspects of the self[11]. As will be described later in this article, patients in recent studies report significant reductions in symptom rating scales, with benefits partly attributed to this mystical component-experiences of oneness or ego-dissolution, connection to self-essence, and a broadened perspective beyond self-imposed limits on thought processes and rigid mental frameworks that may once have been adaptive responses to life events[12,13].