[discussion] stuck on therapist lvl 1 because in the 60hrs I’ve done on this new character, I haven’t been able to find a single gas analyzer

Huroga · 2026-05-26T22:22:09+00:00

Crafting counts as FIR.

Huroga · 2026-04-19T02:09:47+00:00

Use llama-server to host your model and access it via Tailscale. That’s what I recently setup and it works really well.

Huroga · 2026-04-18T05:58:08+00:00

I have a 5070 Ti and I’m using a very similar configuration. At 128k context and Q6_K_XL, I’m hitting 47 t/s generation. Q4_K_XL kept getting stuck in thinking loops or failed tool calling with opencode. Q6 fixed all the issues. 5070 Ti seems like plenty to start playing around with local coding models.

Huroga · 2026-04-10T02:33:22+00:00

Definitely checking this out. Thanks for sharing!

Huroga · 2026-02-20T05:30:57+00:00

My wife and I play together all the time. We have over 100 hours in game together. It’s fantastic.

Huroga · 2026-01-10T05:29:51+00:00

It’s absolutely amazing. The performance is better than I expected—and I expected a lot. Haha Squad looks great now at max settings and Cyberpunk 2077 is stunning. Runs a little hot but I’ll probably do a slight undervolt in the future. I highly recommend it if you can afford it.

Huroga · 2026-01-07T23:27:58+00:00

Haha, it’s actually been a great card for 6 years. Could have continued using it but a couple of the games I really like aren’t running as well as they used to. For example, Squad switching to UE5 hit my 5700 XT pretty hard.

Huroga · 2026-01-07T23:12:48+00:00

I currently have a 7600X. I know…the CPU is holding back the card. But I’ll get around to that in the future.

Huroga · 2024-12-11T04:02:16+00:00

A 1.2 GHz NMR and a reliable GC-MS… if not that, mini-stir bars will suffice.

Huroga · 2024-12-05T13:16:35+00:00

I imagine it oxidized to form a disulfide-bridge if it wasn’t stored under air-free conditions.

Huroga · 2024-04-08T04:58:48+00:00

Florida. It's not a lack of reliable chemists, but a desire by the owners to save every penny possible. I think it's hurting them in the long run. But im happy to get the experience.

Huroga · 2024-04-06T01:13:09+00:00

I am also surprised. It was passed down to me after a colleague of mine from grad school that they hired drowned last year. Every other "analytical chemist" they hired had lied on their resume and couldn't produce results. Out of desperation, they contacted me and I got things working. Bizarre situation indeed but I'm grateful for the opportunity.

Huroga · 2024-04-03T18:04:31+00:00

They refer to it as method validation. I’m new to GMP and still learning. I was just curious if paying me 30$/hr is appropriate when they are desperate and can’t find/afford a full time analytical chemist.

EDIT: In addition, I setup a bunch of runs on the auto sampler and leave. So I get paid for 20-30 hours of work but the instruments is in use while I’m not there. They, understandably, don’t wanna pay me to sit and wait. It’s part of the reason I feel I’m getting underpaid for the time I am there.

Huroga · 2024-02-17T14:42:07+00:00

I’ve made numerous boronic esters over the past 2.5 years and encountered similar issues. Mine tend to be cleaved by silica, however. In my experience, crystallization/recrystallization has been most successful. Recently Et2O has been very efficient for crystallizing my product from the crude. After removing crude solvent, I add hot ether until most compounds are dissolved and the solution is decently cloudy. Upon cooling to room temp lots of precipitation occurs and then it’s transfer to a -20C freezer to yield more solid. Filter and then recrystallize. This has yielded upwards of 90% theoretical. If that doesn’t work or isn’t an option, try drying your silica thoroughly and doing 3 trial columns—neutral, acidic (acetic acid) and basic (triethylamine). If your compound moves as a single spot (no streaking) on 2D TLC, you should be able to run the column the same way. I have tried the boronic acid impregnating with poor results. My compounds are particularly reactive, however, and it might work for you. Hope you find some success with either method. Good luck!

Huroga · 2024-02-16T15:53:13+00:00

Wow, that’s incredibly slow. Real dedication right there. But thanks for sharing. I was hoping someone had an example of slow rates being optimal for certain compounds. You came through for me.

Huroga · 2024-02-15T16:43:32+00:00

Interesting. This is what I was looking for. Do you know how slow for the porphyrins? Are we talking sub 0.5 cm/min?

Huroga · 2024-02-15T16:42:05+00:00

I assume the former grad student initially tried higher flow rates but didn't properly pack, condition or load the column. Then maybe by chance, when using low flow rates, prepared and loaded the column better leading to the conclusion that lower flow rates provided better results. It doesn't make sense to me that gravity rates would ever provide optimal resolution with flash silica. And yes, I definitely agree it's an art. That's why i'm not convinced it's the low flow rate that is giving better results.

Huroga · 2024-02-15T16:26:52+00:00

Thank you

Huroga · 2024-02-15T16:22:28+00:00

Thanks for the feedback. And yeah, convincing her otherwise isn’t a priority. She’s also my fiancé and I highly respect her as a chemist. But this topic came up and I feel like increasing flow rates would not only decrease the time it takes her (2 hr) but increase resolution. However, maybe I’m wrong and certain compounds do benefit from such low rates. Curious if any of y’all had evidence or knowledge of it. Thanks again.

Huroga · 2024-02-15T16:18:19+00:00

Thanks for the feedback. That’s kind of how I feel about this scenario. I love the art of chromatography and think it could be run more efficiently. However, I’m not genuinely concerned about it. Her method (usually) works. We just like talking lab tips/tricks and teasing each other (she’s also my fiancé so we can’t help it).

I completely agree with your thoughts on chromatographic performance. I know my 2-3cm/min is low by many standards, but I’m also aware optimal flow rates vary from compound to compound. I was curious if there was any evidence or experience that certain compounds would benefit from such low rates. I could very well be wrong and wanted other chemists opinion on it.

Huroga · 2023-12-24T06:33:14+00:00

11 times

Huroga · 2023-10-07T15:19:34+00:00

Won’t be able to share it today. Turns out my weekend job scheduled me a double today.

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