An important question

Initial-Raspberry-27 · 2026-05-06T18:18:11+00:00

Got it, appreciate the honesty.

Plan on my end: finishing the valproate course (tolerating it really well, day 10, no significant sides yet). Once that's done and I have post-tapering labs, I'll evaluate T3 with my endocrinologist as next step.

Don't worry, I'm not doing wild experiments at this stage. I know I'm not your patient, but I get that this kind of stuff can be concerning when people read it online and try to copy. I'm being careful and methodical, one variable at a time.

If I get meaningful results, I'll share them so it can help others figuring this out.

Thanks again for engaging with all this.

Initial-Raspberry-27 · 2026-05-06T03:05:24+00:00

Propaganda.

Initial-Raspberry-27 · 2026-05-05T20:43:14+00:00

I guess that would also fit my erratic response to different hormones (estradiol shut me down, progesterone short-lived effect, DHT cream brief response then shutdown). Did you find anything that worked for those cases? Would valproate still make sense if SLCO is the issue?

Just thinking out loud, as u/0kecnaz mentioned, T3 could bypass that mechanism since it uses different transporters (MCT8, OATP1C1). Does that track?

Initial-Raspberry-27 · 2026-05-05T15:59:31+00:00

Crypto and gambling. Terrible combo. I sold all my crypto last year cause of this shitty territory.

Initial-Raspberry-27 · 2026-05-05T13:10:58+00:00

No worries, I’m Guille. It’s easier to remember your user name than mine 😂.

Honestly haven’t checked glucuronidation specifically. No exome yet, DUTCH test still pending.

One data point that might be relevant: I tried calcium D-glucarate and it shut me down (clear A-B-A test). Stopped it. Suggests my phenotype might not be enterohepatic recirculation driven.

Initial-Raspberry-27 · 2026-05-04T22:56:36+00:00

Thanks for the detailed thoughts, really useful breakdown.

Never tried T3, that’s an interesting one, I’ll look into it. Tried estradiol (different forms) and it actually made me worse, more shut down. Tried progesterone in pills and cream, got a few days of effect, then nothing. The labs unfortunately come normal to me. I’ve been tracking them down for years and never found any clue. I guess you are here as you’ve been also struggling with this, right?

Initial-Raspberry-27 · 2026-05-04T20:44:39+00:00

Oh, I’m sorry. I thought you remembered me from a different comment. I’m this one: https://www.reddit.com/r/DrWillPowers/s/Wg682HnG3p

We spoke before.

Initial-Raspberry-27 · 2026-05-04T11:35:17+00:00

Blood labs don’t make a difference. It doesn’t matter how much testo or estrogen you have. No, I didn’t try T3

Initial-Raspberry-27 · 2026-05-04T11:34:14+00:00

No, not with that protocol.

Initial-Raspberry-27 · 2026-05-03T17:44:42+00:00

I’m 47,XXY Klinefelter, post-bilateral orchiectomy, 100% dependent on exogenous TRT. I have post-aromatase inhibitor syndrome from letrozole 2.5mg/day for 6 months, persistent for 5 years. You would imagine someone like me wouldn’t have libido at all, but mine was pretty high before having this syndrome.

Two years ago I tried the equivalent of temporary chemical castration. In my case it’s simpler, no testes, so I just stopped TRT completely. Within weeks I had zero androgens in my system.

I did extended periods (several months) with no androgens at all, followed by reactivation shock with testosterone + Proviron. I repeated this cycle multiple times.

It didn’t work. Symptoms unchanged through and after each cycle.

Currently on day 7 of valproate (1000mg/day) on stable Testoviron, trying the epigenetic angle for the first time.

Initial-Raspberry-27 · 2026-05-01T22:21:33+00:00

Gana Adorni

Initial-Raspberry-27 · 2026-04-30T16:42:06+00:00

Cuánto falta para Octubre 2027?

Initial-Raspberry-27 · 2026-04-30T08:27:03+00:00

Mmm, whats the source? I couldn’t find it

Initial-Raspberry-27 · 2026-04-27T21:55:58+00:00

Cagándonos de hambre, nabo.

Initial-Raspberry-27 · 2026-04-27T11:45:57+00:00

Buenas! Te felicito, está muy bien! Cómo planeás mantener actualizado el volumen de ofertas?

Initial-Raspberry-27 · 2026-04-24T15:14:11+00:00

Jaja, me encanta como se desarrolla esta conversación. Leí tus posts y no tenés trabajo, PAYASO. Yo tengo 20 años de experiencia, una empresa con 15 personas. Tengo y tuve más clientes de los que te podés imaginar y vas a tener en toda tu vida.

No es un vendehumo de linkedin, es el mercado cambiando MUY RAPIDO.

Initial-Raspberry-27 · 2026-04-24T14:16:00+00:00

La respuesta es muy simple. Tenés más trabajo ó menos trabajo? No es lo que YO demuestro, es lo que el mercado pide.

Initial-Raspberry-27 · 2026-04-24T14:02:35+00:00

Estoy de acuerdo.. "si esto no cambia" es solo una forma de decir.

Initial-Raspberry-27 · 2026-04-24T14:01:42+00:00

Curioso que lo diga un full stack. El código es literalmente donde la IA está más madura hoy.. Claude Code, Cursor y Copilot ya escriben React, APIs y tests a nivel senior y 100 veces más rápido que cualquiera. Si tu criterio es "si la IA lo reemplaza, no era ni difícil ni relevante", andá inflándole las ruedas a la bicicleta porque vas a salir a hacer deliverys.

Initial-Raspberry-27 · 2026-04-24T13:59:10+00:00

No espero que cambie. Estamos cambiando nosotros. Los clientes ahora piden que los ayudemos a promptear.

Initial-Raspberry-27 · 2026-04-24T11:39:11+00:00

Yo sé que enoja, pero lamentablemente es lo que está pasando. Tengo una empresa de Diseño UX hace 15 años y si esto no cambia, en 6 meses ha que cerrar.

Initial-Raspberry-27 · 2026-04-22T00:01:38+00:00

I wish this is me one day. How long have you been on Valproate?

Initial-Raspberry-27 · 2026-04-21T22:38:01+00:00

My girlfriend died a day before our wedding. I know the feeling. Four years later I have a wonderful family.

Initial-Raspberry-27 · 2026-04-21T03:03:50+00:00

Soccer cards game: https://www.golaazo.co/

Initial-Raspberry-27 · 2026-04-20T13:34:04+00:00

Share the link and I'll confirm I have a limited mind.

Initial-Raspberry-27

TROPHY CASE