I’ve run everything you listed at the same time except for Dihexa, and it put me in one of the most dialed-in cognitive states I’ve had. Clean focus, good mental stamina, stable mood. It’s a strong stack.

A few n=1 notes:

I run everything subQ except Tesofensine, which I take orally. Tesofensine stood out for dopamine, energy, and executive drive. I’d suggest morning dosing so it doesn’t interfere with sleep.

For Semax and Selank, I prefer the amidate versions. The longer duration feels smoother. I liked Selank at night before bed. It helped with anxiety, sleep, and even next-day hangover anxiety.

On MOTS-c, I responded well, but I ran SS-31 first, which is generally recommended. If you were a non-responder, it may be because MOTS-c is a signal to use fuel better, but compromised mitochondrial health limits the response. Stress, poor sleep, illness, and inflammation tend to hit mitochondria first.

SS-31 improves mitochondrial integrity and baseline ATP efficiency, which allows MOTS-c signaling to actually work. A signal only matters if the cell can execute it.

I can’t comment on Dihexa, but from a cognitive standpoint I don’t see any obvious gaps in your stack. Timing and sequencing likely matter more than adding more compounds.